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    Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
    32.
    发明授权
    Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring 有权
    具有2,5-取代的恶唑并嘧啶环的羧酸衍生物

    公开(公告)号：US08846692B2

    公开(公告)日：2014-09-30

    申请号：US13521831

    申请日：2011-01-12

    Applicant: Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    Inventor： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    IPC: A01N43/90 ,  A61K31/519 ,  C07D279/00 ,  C07D498/04

    CPC classification number: C07D498/04

    Abstract: The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3 and X are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

    Abstract translation: 本发明涉及式I的恶唑并嘧啶化合物，其中A，R 1，R 2，R 3和X如权利要求中所定义。 式I的化合物调节Edg-1受体的活性，特别是该受体的激动剂，并且可用于例如治疗动脉粥样硬化，心力衰竭或外周动脉闭塞性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物组合物。

    Chiplessly thread-forming screw
    35.
    发明授权
    Chiplessly thread-forming screw 有权
    无缝螺纹成型螺丝

    公开(公告)号：US08342788B2

    公开(公告)日：2013-01-01

    申请号：US11804268

    申请日：2007-05-16

    Applicant: Sven Matthiesen ,  Frank Rieger ,  Peter Hertlein ,  Michael Baumgartner ,  Peter Mugg ,  Matthias Schaefer

    Inventor： Sven Matthiesen ,  Frank Rieger ,  Peter Hertlein ,  Michael Baumgartner ,  Peter Mugg ,  Matthias Schaefer

    IPC: F16B25/00

    CPC classification number: F16B25/0021 ,  F16B25/0047 ,  F16B25/0057

    Abstract: A chiplessly thread-forming screw has a stem (11) at one end of which a tip (13) is provided and at another end of which a head (14) is provided, and which has a pointed conical section (21) extending from the tip (13) in a direction of the head (14), a cylindrical section (25) arranged between the first pointed section (21) and the head (14), a first cambered section (22) adjoining the pointed conical section (21) in the direction of the head, and a second cambered section (24) arranged between the first cambered section (22) and the cylindrical section (25) and an outer surface (16) of which has a second curvature radius (R2) unequal to the first curvature radius (R1) of the outer surface (12) of the first cambered section (21).

    Abstract translation: 无芯螺纹形成螺钉具有杆（11），杆的一端处设置有尖端（13），并且其另一端设有头部（14），并且具有尖端的锥形部分（21），其从 所述头部（13）沿所述头部（14）的方向，布置在所述第一尖锐部分（21）和所述头部（14）之间的圆柱形部分（25），邻接所述尖形圆锥形部分的第一弧形部分（22） 21）和位于第一弧形部分（22）和圆柱形部分（25）之间的第二弧形部分（24），其外表面（16）具有第二曲率半径（R2） 不等于第一弧形部分（21）的外表面（12）的第一曲率半径（R1）。

    HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING
    40.
    发明申请
    HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING 有权
    具有2,5-取代的氧杂环糊精环的杂环羧酸衍生物

    公开(公告)号：US20130072502A1

    公开(公告)日：2013-03-21

    申请号：US13521828

    申请日：2011-01-12

    Applicant: Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    Inventor： Dieter Kadereit ,  Matthias Schaefer ,  Stephanie Hachtel ,  Axel Dietrich ,  Thomas Huebschle ,  Katrin Hiss

    IPC: C07D498/04

    CPC classification number: C07D498/04

    Abstract: Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonistsThe present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

    Abstract translation: 包含2,5-取代的恶唑啉嘧啶环作为Edg-1受体激动剂的杂环羧酸衍生物本发明涉及式I的恶唑并嘧啶化合物，其中A，R 1，R 2，R 3，X和Y如 声称。 式I的化合物调节Edg-1受体的活性，特别是该受体的激动剂，并且可用于例如治疗动脉粥样硬化，心力衰竭或外周动脉闭塞性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物组合物。

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