Abstract:
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
Abstract:
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
Abstract:
The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
Abstract:
A power seeding rate adjustment mechanism for a seeding implement has a threaded lead screw that is rotated by an electric motor. A nut threaded onto the lead screw is fixed to the shifter lever such that when the lead screw is rotated, the nut translates along the length of the lead screw to pivot a shifter lever. The shifter lever is in turn coupled to a seed meter drive shaft to move the shaft transversely, thereby moving fluted feed wheels in or out of the seed cups. A switch carried by the operator in the pulling tractor actuates the motor. The adjustment mechanism enables the operator to make adjustments on-the-go without stopping or leaving the tractor. The motor can be disengaged from the lead screw and the screw turned by a hand crank for manual adjustment in the event of a power failure to the motor.
Abstract:
An automated manufacturing cost estimating method and system with indirect cost allocation which identifies a material in an initial state for manufacturing a product in a final state; defines an operation for converting the material from its initial state into the final state of the product; calculates the direct labor cost for each operation based on direct labor hours and calculates the indirect cost specifically allocated for each operation based on consumption of overhead cost elements by the operation; and sums the cost calculated for each operation to determine the total cost of manufacture of a part. Also disclosed is a cost analyzing method and system which utilizes the cost estimating method and system by identifying a plurality of different materials in an initial state for manufacturing a product in a final state and defining a number of manufacturing operations for converting each of the different materials from its initial state into the final state of the product; generating a plurality of paths through the interconnected operations between the different materials in the initial state and the product in the final state; determining a predetermined cost parameter associated with each operation; and accumulating the determined cost parameters along each path.