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公开(公告)号：US20070099906A1
公开(公告)日：2007-05-03
申请号：US11635704
申请日：2006-12-07
申请人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
发明人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
IPC分类号： A61K31/5415 , A61K31/495 , A61K31/155
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
摘要翻译： 本发明的特征在于一种用于治疗患有癌症或其他肿瘤的患者的方法，所述方法通过以足以治疗患者的量彼此同时或相互给药14天内向患者施用两种化合物。
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公开(公告)号：US20070099905A1
公开(公告)日：2007-05-03
申请号：US11585486
申请日：2006-10-24
申请人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell , Debra Gaw , M. Nichols , Margaret Lee
发明人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell , Debra Gaw , M. Nichols , Margaret Lee
IPC分类号： A61K31/551 , A61K31/506 , A61K31/495 , A61K31/4439 , A61K31/4433 , A61K31/381 , A61K31/34
CPC分类号： A61K45/06 , A61K31/496 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
摘要翻译： 本发明的特征在于一种用于治疗患有癌症或其他肿瘤的患者的方法，所述方法通过以足以治疗患者的量彼此同时或相互给药14天内向患者施用两种化合物。
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公开(公告)号：US20050192274A1
公开(公告)日：2005-09-01
申请号：US11024303
申请日：2004-12-28
申请人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
发明人： Alexis Borisy , Curtis Keith , Michael Foley , Brent Stockwell
IPC分类号： A61K9/72 , A61K31/155 , A61K31/54 , A61K31/5415 , A61K45/06 , A61P35/00 , A61P43/00 , A61K31/498 , A61K31/538
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
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公开(公告)号：US20060234991A1
公开(公告)日：2006-10-19
申请号：US11354552
申请日：2006-02-15
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley
IPC分类号： A61K31/573 , A61K31/519
CPC分类号： A61K45/06 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/675 , A61K2300/00
摘要： The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
摘要翻译： 本发明的特征在于药物组合物，其包括双嘧达莫和皮质类固醇。
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公开(公告)号：US20070010502A1
公开(公告)日：2007-01-11
申请号：US11517593
申请日：2006-09-07
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
IPC分类号： A61K31/573 , A61K31/519
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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6.发明申请公开(公告)号：US20050119160A1
公开(公告)日：2005-06-02
申请号：US10966228
申请日：2004-10-15
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
IPC分类号： A61K9/00 , A61K9/20 , A61K31/415 , A61K31/519 , A61K31/525 , A61K31/5415 , A61K31/551 , A61K31/565 , A61K31/59 , A61K31/60 , A61K38/00 , A61K38/13 , A61K45/06
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20070299043A1
公开(公告)日：2007-12-27
申请号：US11732808
申请日：2007-04-04
申请人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
发明人： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
CPC分类号： A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K9/0019 , A61K9/0051 , A61K9/1647 , A61K31/553 , A61K31/573 , A61K47/6957 , A61K2300/00
摘要： The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
摘要翻译： 本发明提供包含抗瘢痕形成药物组合，方法或制造这样的装置或植入物的装置或植入物，以及在装置或植入物和围绕装置或植入物的组织之间抑制纤维化的方法。 本发明还提供包含抗纤维化药物组合的组合物及其在各种医学应用中的用途，包括预防手术粘连，治疗炎性关节炎，治疗瘢痕和瘢痕疙瘩，治疗血管疾病和预防软骨 失利。
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公开(公告)号：US20050187200A1
公开(公告)日：2005-08-25
申请号：US10987554
申请日：2004-11-12
申请人： Benjamin Auspitz , Alexis Borisy , Jason Fong , Nicole Hurst , Edward Jost-Price , Curtis Keith , Palaniyandi Manivasakam , Robyn Sackeyfio , Michael Slavonic , Brendan Smith , Grant Zimmermann
发明人： Benjamin Auspitz , Alexis Borisy , Jason Fong , Nicole Hurst , Edward Jost-Price , Curtis Keith , Palaniyandi Manivasakam , Robyn Sackeyfio , Michael Slavonic , Brendan Smith , Grant Zimmermann
IPC分类号： A61K9/00 , A61K9/20 , A61K31/5415 , A61K31/551 , A61K31/565 , A61K31/573 , A61K31/59 , A61K31/60 , A61K38/13 , A61K45/06
CPC分类号： A61K45/06 , A61K31/565 , A61K38/13 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种通过向患者施用三环化合物和任选的皮质类固醇或其它化合物来治疗被诊断患有免疫炎症疾病或有风险的患者的方法。 本发明还特征在于含有三环化合物和皮质类固醇或其它化合物的药物组合物，用于治疗或预防免疫炎性疾病。
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9.发明申请公开(公告)号：US20120058979A1
公开(公告)日：2012-03-08
申请号：US13292669
申请日：2011-11-09
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A61K31/573 , A61P37/06 , A61K31/575 , A61K31/568 , A61K31/58 , A61K31/57
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20080280863A1
公开(公告)日：2008-11-13
申请号：US12036941
申请日：2008-02-25
申请人： Robyn Sackeyfio , Jason Fong , Nicole Hurst , Palaniyandi Manivasakam , Edward Roydon Jost-Price , Grant Zimmermann , Curtis Keith , Alexis Borisy
发明人： Robyn Sackeyfio , Jason Fong , Nicole Hurst , Palaniyandi Manivasakam , Edward Roydon Jost-Price , Grant Zimmermann , Curtis Keith , Alexis Borisy
CPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , A61K31/56 , A61K31/573 , A61K45/06 , G01N33/6863 , G01N2500/10 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/958 , A61K2300/00
摘要： The invention features methods and compositions for the treatment of immunoinflammatory disorders.
摘要翻译： 本发明的特征在于用于治疗免疫炎性疾病的方法和组合物。
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