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1.发明申请公开(公告)号：US20070196421A1
公开(公告)日：2007-08-23
申请号：US11542211
申请日：2006-10-03
Applicant: William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
Inventor： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC: A61F2/02 , A61K31/7048 , A61K31/7056 , A61K31/55 , A61K31/519 , A61K31/496 , A61K31/56 , A61K33/26 , A61K33/32
CPC classification number: A61F2/02 , A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K31/496 , A61K31/519 , A61K31/55 , A61K31/56 , A61K31/7048 , A61K31/7056 , A61K45/06 , A61L27/54 , A61L2300/00
Abstract: Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring drug combination in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.
Abstract translation: 软组织植入物（例如，乳房，胸部，下巴，面部，唇部和鼻部植入物）与抗瘢痕形成的药物组合组合使用以抑制当将植入物置于动物体内时可能发生的瘢痕形成。
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公开(公告)号：US20070010502A1
公开(公告)日：2007-01-11
申请号：US11517593
申请日：2006-09-07
Applicant: Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
Inventor： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
IPC: A61K31/573 , A61K31/519
CPC classification number: A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
Abstract translation: 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20070198063A1
公开(公告)日：2007-08-23
申请号：US11542163
申请日：2006-10-03
Applicant: William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
Inventor： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC: A61N1/18
CPC classification number: A61N1/372 , A61N1/0568 , A61N1/3605 , A61N1/37 , A61N1/375
Abstract: Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring drug combination or a composition that comprises an anti-scarring drug combination to inhibit scarring that may otherwise occur when the devices are implanted within an animal.
Abstract translation: 与组织接触的电子装置（例如，心律管理和神经刺激装置）与抗瘢痕形成药物组合或包含抗瘢痕形成药物组合的组合物组合使用以抑制当装置植入时可能发生的瘢痕形成 在动物体内
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公开(公告)号：US20060100181A1
公开(公告)日：2006-05-11
申请号：US10513237
申请日：2003-05-02
Applicant: Edward Jost-Price , Palaniyandi Manivasakam , Grant Zimmermann , Jason Fong , Nicole Hurst , Benjamin Auspitz , M Nichols , Curtis Keith
Inventor： Edward Jost-Price , Palaniyandi Manivasakam , Grant Zimmermann , Jason Fong , Nicole Hurst , Benjamin Auspitz , M Nichols , Curtis Keith
IPC: A61K31/573 , A61K31/557
CPC classification number: A61K31/557 , A61K31/56 , A61K31/573 , A61K45/06 , A61K2300/00
Abstract: The invention features methods and compositions for the treatment of inflammatory skin conditions.
Abstract translation: 本发明的特征在于用于治疗炎性皮肤病症的方法和组合物。
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公开(公告)号：US20050187203A1
公开(公告)日：2005-08-25
申请号：US10992878
申请日：2004-11-19
Applicant: Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael Slavonic , Benjamin Auspitz
Inventor： Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael Slavonic , Benjamin Auspitz
IPC: A61K31/4745 , A61K31/573 , C07D471/02
CPC classification number: A61K45/06 , A61K31/415 , A61K31/56 , A61K2300/00
Abstract: The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid, tetra-substituted pyrimidopyrimidine, or other compound. The invention also features pharmaceutical compositions including the combination above for the treatment or prevention of an immunoinflammatory disorder.
Abstract translation: 本发明的特征在于一种方法，用于单独或与皮质类固醇，四取代嘧啶并嘧啶或其它化合物组合施用式（I）化合物，例如异丁司特或KC-764的免疫炎症的方法。 本发明还包括药物组合物，包括上述用于治疗或预防免疫炎性疾病的组合。
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Patent Agency Ranking
6.发明申请Implantable sensors, implantable pumps and anti-scarring drug combinations 审中-公开植入式传感器，植入式泵和抗疤痕药物组合公开(公告)号：US20070197957A1
公开(公告)日：2007-08-23
申请号：US11542101
申请日：2006-10-03
Applicant: William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
Inventor： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC: A61M31/00
CPC classification number: A61L31/10 , A61K9/0024 , A61L31/16 , A61L2300/602 , A61M5/14276 , A61M31/002
Abstract: Pumps and sensors for contact with tissue are used in combination with an anti-scarring agent or a composition that comprises an anti-scarring agent to inhibit scarring that may otherwise occur when the pumps and sensors are implanted within an animal.
Abstract translation: 用于与组织接触的泵和传感器与抗瘢痕形成剂或包含抗瘢痕形成剂的组合物组合使用以抑制当将泵和传感器植入动物体内时可能发生的瘢痕形成。
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7.发明申请Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines 审中-公开用于治疗与增加炎症细胞因子水平相关的疾病和病症的方法和试剂公开(公告)号：US20050153947A1
公开(公告)日：2005-07-14
申请号：US10947455
申请日：2004-09-20
Applicant: Mahesh Padval , Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Jason Fong , Benjamin Auspitz , M. Nichols , Curtis Keith , Grant Zimmerman , Bradley Brasher , Noah Sachs , Todd Chappell
Inventor： Mahesh Padval , Edward Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Jason Fong , Benjamin Auspitz , M. Nichols , Curtis Keith , Grant Zimmerman , Bradley Brasher , Noah Sachs , Todd Chappell
IPC: A61K9/00 , A61K9/20 , A61K31/00 , A61K31/565 , A61K38/13 , A61K45/06 , A61K31/573 , A61K31/137
CPC classification number: A61K45/06 , A61K9/0073 , A61K9/209 , A61K31/00 , A61K31/565 , A61K38/13 , A61K2300/00
Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
Abstract translation: 本发明的特征在于通过向患者施用SSRI或其类似物或代谢物，以及任选的皮质类固醇或其它化合物来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还具有含有SSRI或其类似物或代谢物以及用于治疗或预防免疫炎性疾病的皮质类固醇或其他化合物的药物组合物。
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8.发明申请公开(公告)号：US20050119160A1
公开(公告)日：2005-06-02
申请号：US10966228
申请日：2004-10-15
Applicant: Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
Inventor： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael Foley , Michael Slavonic , Brendan Smith , Benjamin Auspitz
IPC: A61K9/00 , A61K9/20 , A61K31/415 , A61K31/519 , A61K31/525 , A61K31/5415 , A61K31/551 , A61K31/565 , A61K31/59 , A61K31/60 , A61K38/00 , A61K38/13 , A61K45/06
CPC classification number: A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
Abstract translation: 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20070208134A1
公开(公告)日：2007-09-06
申请号：US11542185
申请日：2006-10-03
Applicant: William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
Inventor： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
IPC: A61K47/48
CPC classification number: A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K47/6957
Abstract: The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
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公开(公告)号：US20070299043A1
公开(公告)日：2007-12-27
申请号：US11732808
申请日：2007-04-04
Applicant: William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
Inventor： William Hunter , Philip Toleikis , David Gravett , Daniel Grau , Alexis Borisy , Curtis Keith , Benjamin Auspitz , M. Nichols , Edward Jost-Price , George Serbedzija
CPC classification number: A61F2/0077 , A61F2250/0067 , A61F2250/0068 , A61K9/0019 , A61K9/0051 , A61K9/1647 , A61K31/553 , A61K31/573 , A61K47/6957 , A61K2300/00
Abstract: The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.
Abstract translation: 本发明提供包含抗瘢痕形成药物组合，方法或制造这样的装置或植入物的装置或植入物，以及在装置或植入物和围绕装置或植入物的组织之间抑制纤维化的方法。 本发明还提供包含抗纤维化药物组合的组合物及其在各种医学应用中的用途，包括预防手术粘连，治疗炎性关节炎，治疗瘢痕和瘢痕疙瘩，治疗血管疾病和预防软骨 失利。
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