公开(公告)号：US20210130460A1

公开(公告)日：2021-05-06

申请号：US17084751

申请日：2020-10-30

Applicant: MORPHOSYS AG

Inventor： Sumeet Ambarkhane ,  Johannes Weirather

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/454 ,  A61P35/00

Abstract: The present disclosure is directed to a therapeutic combination of an anti-CD19 antibody and lenalidomide for use in the treatment of hematological cancer patients. Furthermore, the present disclosure concerns extending the overall survival and/or the progression free survival in patients having specific types of hematological cancer.

公开(公告)号：US20210130451A1

公开(公告)日：2021-05-06

申请号：US17144685

申请日：2021-01-08

Applicant: MORPHOSYS AG

Inventor： Stefan HARTLE ,  Stephane LECLAIR ,  Amgad SHEBL ,  Stefan STEIDL ,  Bodo BROCKS ,  Daniela Della DUCATA ,  Kai ROSPORT

IPC: C07K16/24 ,  A61K31/519 ,  A61K39/395

Abstract: The present invention provides anti-GM-CSF antibodies for use in the treatment of rheumatoid arthritis. Anti-GM-CSF antibodies, in particular MOR103, are administered to patients suffering from rheumatoid arthritis at dosages that are beneficial in a clinical setting.

公开(公告)号：US20200231963A1

公开(公告)日：2020-07-23

申请号：US16843299

申请日：2020-04-08

Applicant: MorphoSys AG

Inventor： Roger Müller ,  Andreas Bültmann ,  Josef Prassler ,  Markus Moosmeier

IPC: C12N15/10 ,  C40B40/02 ,  C40B40/10

Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.

公开(公告)号：US20200024340A1

公开(公告)日：2020-01-23

申请号：US16442779

申请日：2019-06-17

Applicant: MORPHOSYS AG

Inventor： Stefan Steidl ,  Elisabeth THOMASSEN-WOLF

IPC: C07K16/24

Abstract: The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

公开(公告)号：US10308722B2

公开(公告)日：2019-06-04

申请号：US15670811

申请日：2017-08-07

Applicant: MORPHOSYS AG

Inventor： Lisa Rojkjaer ,  Rainer Boxhammer ,  Jan Endell ,  Mark Winderlich ,  Christofer Samuelsson

IPC: A61K39/395 ,  C07K16/40 ,  A61K31/454 ,  A61K38/05 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  A61K31/69 ,  A61K38/07 ,  A61K39/00

Abstract: The present disclosure is directed to a method of treating multiple myeloma or non-hodgkins lymphoma with a pharmaceutical composition comprising an anti-CD38 antibody in combination with thalidomide, lenalidomide, or pomalidomide.

公开(公告)号：US20180340024A1

公开(公告)日：2018-11-29

申请号：US16058143

申请日：2018-08-08

Applicant: MORPHOSYS AG ,  GALAPAGOS NV

Inventor： Jan Dominik HAAS ,  Jürgen KLATTIG ,  Nick Ernest René VANDEGHINSTE

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K39/395 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antibodies or antibody fragments binding to human IL-17C. In particular, it relates to antibodies or antibody fragments that have combined beneficial properties and are therefore useful for the treatment of humans having, for example, atopic dermatitis or psoriasis.

公开(公告)号：US20170342147A1

公开(公告)日：2017-11-30

申请号：US15535487

申请日：2015-12-15

Applicant: MorphoSys AG ,  Galapagos NV

Inventor： Jürgen Klattig ,  Nick Ernest René Vandeghinste ,  Teresa Garcia

IPC: C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antibodies or antibody fragments binding to human IL-17C. In particular, it relates to antibodies or antibody fragments that bivalently bind to homodimeric IL-17C.

公开(公告)号：US20170218061A1

公开(公告)日：2017-08-03

申请号：US15386152

申请日：2016-12-21

Applicant: MORPHOSYS AG

Inventor： Stefan Steidl ,  Elisabeth Thomassen-Wolf

IPC: C07K16/24

CPC classification number: C07K16/243 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

公开(公告)号：US20170183395A1

公开(公告)日：2017-06-29

申请号：US15455582

申请日：2017-03-10

Applicant: MorphoSys AG

Inventor： Josef Prassler ,  David Ott ,  Stefanie Thiel ,  Yvonne Stark ,  Ute Keck ,  Thomas Pietzonka ,  Hilmar Ebersbach

IPC: C07K16/00 ,  C07K16/24 ,  G01N33/68

CPC classification number: C07K16/005 ,  C07K16/00 ,  C07K16/22 ,  C07K16/243 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6854

Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.

公开(公告)号：US09579378B2

公开(公告)日：2017-02-28

申请号：US14430801

申请日：2013-09-24

Applicant: MORPHOSYS AG

Inventor： Jan Endell ,  Lisa Rojkjaer

IPC: A61K38/00 ,  A61K39/395 ,  C07K16/28 ,  A61K31/198 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K31/198 ,  A61K39/3955 ,  A61K2039/545 ,  C07K16/2896 ,  A61K2300/00

Abstract: The present disclosure describes a pharmaceutical combination of an anti-CD38 antibody and melphalan.

Abstract translation: 本公开描述了抗CD38抗体和美法仑的药物组合。