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公开(公告)号：US09541559B2
公开(公告)日：2017-01-10
申请号：US14242906
申请日：2014-04-02
Applicant: MorphoSys AG
Inventor： Stefanie Urlinger , Thomas Tiller , Ingrid Schuster , Yvonne Stark
CPC classification number: G01N33/6854 , C07K16/005 , C07K2317/55 , C07K2317/567 , C12N15/1037 , C40B40/08
Abstract: The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select against any antigen using, for example, phage display.
Abstract translation: 本公开使得可变重链和可变轻链对的收集部分包含预先选择用于与显影性相关的功能性质的种系蛋白序列，其中所述集合可以用于使用例如， 噬菌体展示。
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公开(公告)号：US20170183395A1
公开(公告)日：2017-06-29
申请号：US15455582
申请日：2017-03-10
Applicant: MorphoSys AG
Inventor： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
CPC classification number: C07K16/005 , C07K16/00 , C07K16/22 , C07K16/243 , C07K2317/20 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , G01N33/6854
Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
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公开(公告)号：US20140206575A1
公开(公告)日：2014-07-24
申请号：US14242906
申请日：2014-04-02
Applicant: MorphoSys AG
Inventor： Stefanie Urlinger , Thomas Tiller , Ingrid Schuster , Yvonne Stark
CPC classification number: G01N33/6854 , C07K16/005 , C07K2317/55 , C07K2317/567 , C12N15/1037 , C40B40/08
Abstract: The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select against any antigen using, for example, phage display.
Abstract translation: 本公开使得可变重链和可变轻链对的收集部分包含预先选择用于与显影性相关的功能性质的种系蛋白序列，其中所述集合可以用于使用例如， 噬菌体展示。
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公开(公告)号：US10919955B2
公开(公告)日：2021-02-16
申请号：US15455582
申请日：2017-03-10
Applicant: MorphoSys AG
Inventor： Josef Prassler , David Ott , Stefanie Thiel , Yvonne Stark , Ute Keck , Thomas Pietzonka , Hilmar Ebersbach
Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.
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