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公开(公告)号：US10137097B2
公开(公告)日：2018-11-27
申请号：US15574651
申请日：2016-06-08
Inventor： Hidemitsu Nakajima
IPC: A61K31/16 , A61K31/10 , A61P25/28 , A61P25/16 , A61K31/164 , C07C323/57
Abstract: [Problem] Provided is a non-peptide compound which can be used as a GAPDH aggregation inhibitor. [Solution] Provided is a GAPDH aggregation inhibitor including as an active ingredient a compound represented by the chemical formula 1 wherein R1, R2, and R3 are each independently a hydrogen atom, a halogen atom, or an aliphatic hydrocarbon group having a carbon number of from 1 to 10, a polysulfurized derivative thereof, or a pharmaceutically acceptable salt thereof. The present compound has a GAPDH aggregation inhibitory activity to suppress intracerebral aggregation of various proteins involved in cerebral neurodegenerative diseases, thereby contributing to improvement in various brain neurological diseases associated with aggregation of these proteins such as Alzheimer's disease, Parkinson's disease, and cerebral infarction, and prevention of advanced seriousness of these diseases.
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公开(公告)号：US10125406B2
公开(公告)日：2018-11-13
申请号：US15108406
申请日：2014-12-28
Inventor： Yasuhiro Konishi , Norizo Saito , Masao Kishida
Abstract: The present application provides a method to recover noble metal ions by reduction with using yeast. In the method, a liquid containing noble metal ions is provided. An electron donor and yeast are added into the liquid to bring the yeast in contact with the noble metal ions to reduce the noble metal ions. The noble metal can be accumulated in a fungus body of the yeast. The electron donor can be an organic acid, a salt thereof, an alcohol and hydrogen gas.
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33.发明申请公开(公告)号：US20180214528A1
公开(公告)日：2018-08-02
申请号：US15881452
申请日：2018-01-26
Inventor： Ikuhiko NAKASE , Kosuke NOGUCHI , Nahoko BAILEYKOBAYASHI , Tetsuhiko YOSHIDA
CPC classification number: A61K39/0011 , A61K9/127 , A61K35/36 , A61K35/54
Abstract: The pharmaceutical composition for inhibiting expression of CD47 in tumor cells provided by the present invention contains: exosomes produced by cultured tumor cells in an amount effective for inhibiting expression of the CD47; and a pharmaceutically acceptable carrier.
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公开(公告)号：US09903861B2
公开(公告)日：2018-02-27
申请号：US14894452
申请日：2014-05-30
Inventor： Takuya Iida , Shiho Tokonami
IPC: G01N21/21 , G01N33/543 , G01N21/552 , G01N21/65 , G01N33/53 , G01N33/553 , C12Q1/68
CPC classification number: G01N33/54346 , C12Q1/6834 , C12Q2563/155 , C12Q2565/628 , G01N21/21 , G01N21/554 , G01N21/658 , G01N33/5308 , G01N33/553 , G01N2201/061 , G01N2201/0683
Abstract: A detection device detects an analyte that may be contained in a specimen. The detection device includes a plurality of gold nanoparticles, an optical trapping light source, an illumination light source, an objective lens, an image pick-up device, and a computation unit. The plurality of gold nanoparticles are each modified with a probe DNA allowing the analyte to specifically adhere thereto. The optical trapping light source emits polarized light for assembling the plurality of gold nanoparticles together. The objective lens focuses and introduces the polarized light into a liquid containing a specimen and the plurality of gold nanoparticles. The image pick-up device receives light from the liquid. The computation unit detects an analyte based on a signal received from the image pick-up device.
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公开(公告)号：US09800106B2
公开(公告)日：2017-10-24
申请号：US15122476
申请日：2015-03-04
Inventor： Toshinari Kondou , Masayuki Sanada , Shigeo Morimoto , Yukinori Inoue
CPC classification number: H02K1/276 , H02K1/02 , H02K2213/03
Abstract: Satisfactory magnet torque is achieved while avoiding a reduction in the reluctance torque generated. The rotor core is provided with a plurality of magnet slots arranged in the circumferential direction of the rotor core and a gap formed of base holes and a projecting hole. The base holes extend from both ends in the circumferential direction of each magnet slot to the outer side of the rotor core. The projecting hole projects in the circumferential direction of the rotor core from at least one of peripheral portions, opposed to each other, of the base holes provided at both of the ends of the magnet slot, when viewed in an axial direction. The projecting hole is located closer to the magnet slot than to an outer peripheral side end of the base hole.
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Patent Agency Ranking
36.发明申请公开(公告)号：US20170246304A1
公开(公告)日：2017-08-31
申请号：US15585228
申请日：2017-05-03
Inventor： Ikuhiko Nakase , Tetsuhiko Yoshida , Nahoko Baileykobayashi
CPC classification number: A61K47/46 , A61K9/5063 , A61K38/1808
Abstract: Provided is a novel material used to introduce an exogenous substance into cells. Also provided is a method for introducing an exogenous substance into target cells using this material. The present invention provides an exosome that is used to introduce an exogenous substance into target cells, wherein the exosome contains one type or two or more types of an exogenous substance and a substance that induces macropinocytosis in the target cells. The present invention also provides a composition containing the exosome and a method for introducing an exogenous substance into cells using this exosome.
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公开(公告)号：US20160348257A1
公开(公告)日：2016-12-01
申请号：US15169116
申请日：2016-05-31
Inventor： Shunsuke YAGI , Ikuya YAMADA , Kouhei WADA
CPC classification number: C25B11/0463 , C25B1/04 , Y02E60/366
Abstract: A catalyst for an oxygen evolution reaction has a higher and longer-life catalytic activity than that of the conventional and expensive noble metal oxide catalysts, such as RuO2 and IrO2. An A-site ordered perovskite oxide catalyst (such as CaCu3Fe4O12 and CaMn3Mn4O12 etc.) as an oxygen evolution reaction catalyst is excellent in cost effectiveness. The catalyst has a high catalytic activity compared with a noble metal oxide catalyst, and a long repetition use life since it is extremely stable also under the oxidative reaction conditions. Use of the catalyst is expected to the important energy conversion reactions such as a charge reaction of a metal-air battery, an anode oxygen evolution reaction in the case of a direct water decomposition reaction by sunlight, etc.
Abstract translation: 用于析氧反应的催化剂具有比常规和昂贵的贵金属氧化物催化剂如RuO 2和IrO 2更高和更长寿命的催化活性。 作为析氧反应催化剂的A位置的钙钛矿氧化物催化剂（例如CaCu 3 Fe 4 O 12和CaMn 3 Mn 4 O 12等）具有优异的成本效益。 催化剂与贵金属氧化物催化剂相比具有高催化活性，并且由于在氧化反应条件下也极其稳定，因此重复使用寿命长。 催化剂的使用预期是重要的能量转换反应，例如金属 - 空气电池的电荷反应，在阳光直接水分解反应的情况下的阳极氧析出反应等。
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38.发明申请PRODUCTION METHOD FOR 2-FLUORO-4-BORONO-L-PHENYLALANINE, AND PRECURSOR OF 2-FLUORO-4-BORONO-L-PHENYLALANINE 有权2-氟-4-溴硼酸-L-苯乙烯胺的制备方法和2-氟-4-溴硼酸 - 苯甲酰胺的前体公开(公告)号：US20160311836A1
公开(公告)日：2016-10-27
申请号：US15105401
申请日：2014-12-16
Inventor： Hiroshi Takenaka , Yoichiro Ohta , Yusuke Taguchi , Sayuri Ueda , Yuko Ishino , Tomohiro Yoshikawa , Hideki Nakashima , Kohki Uehara , Mitsunori Kirihata
IPC: C07F5/02 , C07C229/36
CPC classification number: C07F5/027 , C07C229/36 , C07C251/24 , C07C271/22 , Y02P20/55
Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N═N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C═N, wherein NR40R50 are together.)
Abstract translation: 本发明涉及制备由式表示的化合物。 （式中，R 1表示Br基，碘基，Cl基，NO 2基或NH 2基; R 2表示卤素基，NO 2基，NH 2基，Sn（R 6）3，N = N-NR7R8，OSO2R9，NR10R11，苯基碘鎓，杂环基碘，硼酸或硼酸酯; R30表示保护基PG1; R40或R50表示氢，保护基PG2或C6H5（C6H5） 其中NR40R50在一起。）
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39.发明授权Waveguide-type image rejection filter and single-sideband receiver, frequency divider, and sideband-separating receiver using the same filter 有权波导型图像抑制滤波器和单边带接收机，分频器和使用相同滤波器的边带分离接收机公开(公告)号：US09397378B2
公开(公告)日：2016-07-19
申请号：US14768618
申请日：2014-01-30
Inventor： Yutaka Hasegawa , Hideo Ogawa , Shin'ichiro Asayama
CPC classification number: H01P1/213 , H01P1/208 , H01P1/2138 , H01P5/16 , H04B1/16
Abstract: An image rejection filter comprising a waveguide-type 90-degree hybrid coupler having an input port for receiving an input signal within a millimeter or submillimeter band, first and second output ports for dividing the input signal in two and outputting the divided signals, respectively, wherein the one signal deviates by a 90-degree phase from the other signal, and a branch port for outputting the signal; a pair of band pass filters: a waveguide-type first band pass filter whose one end is connected with the first output port and a waveguide-type second band pass filter whose one end is connected with the second output port; and a pair of radiowave absorptive terminations: a first radiowave absorptive termination connected to the other end of the first band pass filter and a second radiowave absorptive termination connected to the other end of the second band pass filter.
Abstract translation: 一种镜像抑制滤波器，包括波导型90度混合耦合器，具有用于接收毫米或亚毫米波段内的输入信号的输入端口，用于将输入信号分成两部分并输出分频信号的第一和第二输出端口， 其中所述一个信号与其他信号偏离90度相位，以及用于输出所述信号的分支端口; 一对带通滤波器：一端与第一输出端口连接的波导型第一带通滤波器和一端与第二输出端口连接的波导型第二带通滤波器; 以及一对无线电波吸收终端：连接到第一带通滤波器的另一端的第一无线电波吸收终端和连接到第二带通滤波器另一端的第二无线电波吸收终端。
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公开(公告)号：US09252556B2
公开(公告)日：2016-02-02
申请号：US14441029
申请日：2013-10-31
Applicant: FUJIKURA LTD. , NIPPON TELEGRAPH AND TELEPHONE CORPORATION , OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION , National University Corporation Shimane University
Inventor： Shoichiro Matsuo , Katsuhiro Takenaga , Kentaro Ichii , Hirotaka Ono , Kyouzou Tsujikawa , Makoto Yamada , Hiroji Masuda
CPC classification number: H01S3/06754 , G02B6/02042 , G02B6/03605 , G02B6/03611 , H01S3/06729 , H01S3/06733 , H01S3/06737 , H01S3/091 , H01S3/094007 , H01S3/2383
Abstract: The first cladding 52 has a two-layer structure formed of a solid inner layer 62A passed through the center axis of the first cladding 52 and an outer layer 62B enclosing the inner layer 62A and the plurality of cores 51 with no gap. A refractive index n1 of the core 51 is provided higher than refractive indexes n2A and n2B of the inner layer 62A and the outer layer 62B, the refractive indexes n2A and n2B of the inner layer 62A and the outer layer 62B are provided higher than a refractive index n3 of the second cladding 53, and the refractive index n2A of the inner layer 62A is provided lower than the refractive index n2B of the outer layer 62B.
Abstract translation: 第一包层52具有由穿过第一包层52的中心轴线的实心内层62A和不间隙地包围内层62A和多个芯51的外层62B形成的两层结构。 芯体51的折射率n1比内层62A和外层62B的折射率n2A，n2B高，内层62A和外层62B的折射率n2A，n2B高于屈光度 第二包层53的折射率n3和内层62A的折射率n2A被设定为低于外层62B的折射率n2B。
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