公开(公告)号：US12059190B2

公开(公告)日：2024-08-13

申请号：US17319157

申请日：2021-05-13

Applicant: Technion Research & Development Foundation Limited ,  Rambam Med-Tech Ltd.

Inventor： Yakov Krasik ,  Joshua Felsteiner ,  Yakov Slutsker ,  Ziv Gil ,  Jacob Cohen ,  Yoav Binenbaum

IPC: H05H1/00 ,  A61B1/018 ,  A61B18/04 ,  H05H1/24 ,  A61B17/00 ,  A61B18/00

CPC classification number: A61B18/042 ,  A61B1/018 ,  H05H1/2406 ,  A61B2017/00039 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2018/00791 ,  A61B2018/00982 ,  H05H1/245 ,  H05H1/246 ,  H05H1/2465 ,  H05H2245/32 ,  H05H2245/34

Abstract: A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.

公开(公告)号：US11875818B2

公开(公告)日：2024-01-16

申请号：US17297695

申请日：2019-11-28

Applicant: RAMBAM MED-TECH LTD. ,  BAR-ILAN UNIVERSITY

Inventor： Jacob Cohen ,  Joseph Keshet ,  Alma Cohen

IPC: G10L25/66 ,  A61B5/00 ,  G10L25/78 ,  G10L25/90

CPC classification number: G10L25/66 ,  A61B5/0022 ,  A61B5/4803 ,  G10L25/78 ,  G10L25/90 ,  G10L2025/906

Abstract: Systems and methods of predicting glottal insufficiency by at least one hardware processor including receiving a voice recording comprising a phonation by a subject, analysis of the voice recording to calculate a fundamental frequency contour curve of the phonation, and measurement of at least one of (i) a time period from a start of the phonation until the contour curve reaches a settled level, (ii) a slope of the contour curve during the time period, and (iii) an area under the contour curve during that time period. In certain embodiments, the processor subsequently, determines a glottal closure insufficiency in the subject based on these measurements.

公开(公告)号：US20230330064A1

公开(公告)日：2023-10-19

申请号：US18004821

申请日：2021-07-08

Applicant: Technion Research & Development Foundation Limited ,  RAMBAM MED-TECH LTD.

Inventor： Ido LIVNEH ,  Victoria COHEN-KAPLAN ,  Aaron CIECHANOVER ,  Gilad GOLDHIRSH ,  Yaniv ZOHAR ,  Noa LAVI ,  Bertrand Francois FABRE

IPC: A61K31/405 ,  A61P35/00 ,  A61K31/198 ,  G01N33/50

CPC classification number: A61K31/405 ,  A61P35/00 ,  A61K31/198 ,  G01N33/5035 ,  G01N33/5082

Abstract: The present disclosure provides mTOR agonists that selectively modulate proteasome dynamics, compositions, methods and uses thereof for modulation of stress-induced proteasome dynamics and related pathological conditions. The present disclosure specifically provides therapeutic methods for treating disorders associated with cytosolic accumulation of the proteasome. The invention further provides prognostic methods for detection and monitoring drug resistant cancers, as well as methods for screening for modulators of proteasome dynamics.

公开(公告)号：US20230258644A1

公开(公告)日：2023-08-17

申请号：US18012551

申请日：2021-06-24

Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY ,  RAMBAM MED-TECH LTD

Inventor： Robert MARKS ,  Yehuda CHOWERS ,  Tim AXELROD ,  Sigal PRESSMAN ,  Ron RAMON

IPC: G01N33/574 ,  G01N33/543 ,  G01N33/564

CPC classification number: G01N33/57488 ,  G01N33/54388 ,  G01N33/564

Abstract: Disclosed is a device including at least 4 sections with a unique layout which includes a surface functionalized with an agent having specific binding affinity to a target molecule, and which allows lateral flow. Disclosed are also a kit and a method for determining and quantifying the presence of an analyte in a sample.

公开(公告)号：US20220134068A1

公开(公告)日：2022-05-05

申请号：US17431230

申请日：2020-02-14

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  RAMBAM MED-TECH LTD.

Inventor： Eyal ZUSSMAN ,  Gilad AMIEL ,  Idan SHLOMI ,  Ahmad KABHA

IPC: A61M31/00 ,  A61L31/14 ,  A61L31/10 ,  A61L31/16 ,  A61F2/04

Abstract: Compositions comprising electrospun fibers and active (e.g. pharmaceutical) agents encapsulated thereto are provided. Further, articles and methods of use of the fibers, including, but not limited to coating of medical tubing, are provided.

公开(公告)号：US20210386784A1

公开(公告)日：2021-12-16

申请号：US17412572

申请日：2021-08-26

Applicant: RAMBAM MED-TECH LTD.

Inventor： Igal LOURIA-HAYON ,  Yishai OFRAN ,  Michal HAYUN

IPC: A61K35/17 ,  A61K45/06 ,  C07K14/47

Abstract: Cells comprising an exogenous protein and decreased SH2B adapter protein 3 (SH2B3) protein expression and/or function are provided. Pharmaceutical compositions comprising the cells of the invention as well as methods of treating a disease in a subject in need thereof comprising administering a cell and/or a pharmaceutical composition of the invention, and of determining suitability for treatment, are also provided.

公开(公告)号：US20200315829A1

公开(公告)日：2020-10-08

申请号：US16835608

申请日：2020-03-31

Applicant: RAMBAM MED-TECH LTD.

Inventor： Ilana Zehavit SCHLESINGER ,  Alon SINAI

IPC: A61F5/00 ,  A61N7/02 ,  A61B5/00 ,  A61B5/055 ,  A61B17/32

Abstract: A method is provided for inducing weight loss in a subject. The method includes using an energy source, applying energy to thalamic nuclei of a subject, modifying at least a portion of the thalamic nuclei by applying the energy, and inducing weight loss in the subject.

公开(公告)号：US10351911B2

公开(公告)日：2019-07-16

申请号：US15136929

申请日：2016-04-24

Applicant: Technion Research & Development Foundation Limited ,  Ramot at Tel-Aviv University Ltd. ,  Walter Gabriel Wasser ,  Rambam Med-Tech Ltd.

Inventor： Karl Skorecki ,  Shay Tzur ,  Saharon Rosset ,  Walter Gabriel Wasser ,  Doron M. Behar ,  Revital Shemer

IPC: C12Q1/70 ,  G01N33/68 ,  C12Q1/6883

Abstract: Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.

公开(公告)号：US20170333027A1

公开(公告)日：2017-11-23

申请号：US15526769

申请日：2015-11-12

Applicant: RAMBAM MED-TECH LTD.

Inventor： Yaniv Keren ,  Yaron Berkovich

IPC: A61B17/04 ,  A61B17/56

CPC classification number: A61B17/0401 ,  A61B17/04 ,  A61B17/0482 ,  A61B17/56 ,  A61B17/8645 ,  A61B17/8685 ,  A61B2017/0411 ,  A61B2017/0414 ,  A61B2017/044 ,  A61B2017/0446 ,  A61B2090/037

Abstract: Embodiments of the bone anchor assembly (36, 50) described herein have adjustable lengths and therefore accommodate many needs. Therefore, the physician does not need to maintain a multitude of bone anchors having a variety of lengths in order to be prepared for many situations. The bone anchor assembly (36, 50) has an elongated hollow shaft portion (38, 52) formed of multiple shaft segments (46, 58) joined together. The length of the shaft portion (38, 52) is adjusted after the implanting of the bone anchor assembly into the bone by removing shaft segments (46, 58).