公开(公告)号：US20190231959A1

公开(公告)日：2019-08-01

申请号：US16225680

申请日：2017-06-15

Applicant: SHIBUYA CORPORATION

Inventor： Nobuyuki NOZATO ,  Shingo SAITO

IPC: A61M1/16 ,  B01F1/00 ,  B01F15/00

CPC classification number: A61M1/1666 ,  A61M1/16 ,  A61M2205/3331 ,  B01F1/0027 ,  B01F15/00162 ,  B01F15/00344 ,  B01F2215/0034

Abstract: This dialysis device is configured so that residual liquid in a powder container 42 and a bypass path 51 can be drained. Accordingly, the dialysis device is provided with: a first liquid draining path 71 connecting a clean water supply path 31 to a stock solution supply path 44 on the upstream side of a liquid feed pump 33; a second liquid draining path 72 connecting the clean water supply path to a dialysate discharge path 32 on the downstream side of the liquid feed pump; and an opening path 77 allowing a branch path 43 to communicate with the outer space by opening an on-off valve 78. By opening the on-off valve of the opening path and actuating the liquid feed pump, a liquid in the powder container 42 and a liquid in the bypass path 51 can be discharged through the first liquid draining path and the second liquid draining path.

公开(公告)号：US20190160108A1

公开(公告)日：2019-05-30

申请号：US16320763

申请日：2017-07-11

Applicant: YAMAGUCHI UNIVERSITY ,  SHIBUYA CORPORATION

Inventor： Isao SAKAIDA ,  Taro TAKAMI ,  Kenji YONEDA

IPC: A61K35/28 ,  C12N5/077 ,  C12M1/26 ,  C12M1/12

Abstract: A bone marrow fluid of a patient is sampled, housed in a collection tube 11 and conveyed into an isolator in a sterile state. In the isolator, the bone marrow fluid in the collection tube is pipetted into test tubes and culture tube, etc. To the bone marrow fluid in the tubes, an erythrocyte sedimentation agent is added. After precipitating erythrocytes, the supernatant is collected. From the collected supernatant, a bone marrow cell-containing fraction for liver regeneration is concentrated and pipetted into flasks which are conveyed into an incubator to start the cell-culture. From the isolator system, test tubes are taken out. The bone marrow fluid in the test tubes and the concentrate are subjected to a safety test, etc.

公开(公告)号：US20180311389A1

公开(公告)日：2018-11-01

申请号：US15954137

申请日：2018-04-16

Applicant: SHIBUYA CORPORATION

Inventor： Soma WATANABE ,  Yusuke HIROSAWA ,  Katsuki HASHIMOTO

IPC: A61L2/20

CPC classification number: C12M37/00 ,  A61L2/20 ,  C12M23/44 ,  C12M41/14

Abstract: In a state where an incubator 3 is connected to an isolator 2 through a chamber 4 and opening/closing doors 11B and 12 are closed, a decontaminating gas G is supplied to the chamber 4 through gas supply passages 16 and 26, and an inside thereof is decontaminated (FIGS. 2(a), (b)).Subsequently, an air is supplied into the chamber 4 through the gas supply passages 16 and 26 and initial aeration is carried out by discharging a gas in the chamber 4 through a gas discharge passage 27 (FIG. 2(b)).Subsequently, after the opening/closing door 11B is opened, when both blowers B1 and B4 are stopped, the gas at a positive pressure in the isolator 2 is introduced into the chamber 4 (FIG. 2(c)). Thus, the gas containing the decontaminating gas G in the chamber 4 is rapidly discharged to an outside through the gas supply passages 26 and 16 and the gas discharge passage 27, and aeration in the chamber 4 is completed.Time required for the aeration of the chamber 4 can be drastically reduced as compared with before.

公开(公告)号：US10106769B2

公开(公告)日：2018-10-23

申请号：US15322643

申请日：2015-06-12

Applicant: SHIBUYA CORPORATION

Inventor： Masahiro Sakamoto ,  Noriaki Nishimura

IPC: C12M1/36 ,  G01N35/02 ,  G01N35/10 ,  C12M1/02 ,  C12M1/24 ,  C12M1/26 ,  C12M1/12 ,  C12M1/00

Abstract: An automatic culturing device configured such that, in a work chamber 2a maintained in a sterile state, first and second robots 6 and 7 are arranged so that the movable ranges thereof partially overlap each other, and such that liquid supply means 10 which supplies liquids, containing a culture medium and liquid medicine, to containers held by the robots, and temporary placement sections (handing-over table 42, centrifuge tube holder 43, and heated room 44), each of which hands over the containers between the first and second robots, are provided in the movable ranges of the first and second robots, which ranges overlap each other.The first robot takes out the containers housed in housing means (rotary stocker 8), and the second robot holds and transports the containers handed over from the first robot via the temporary placement section.The cultivating operation can be efficiently performed.

公开(公告)号：US09789480B2

公开(公告)日：2017-10-17

申请号：US14978139

申请日：2015-12-22

Applicant: SHIBUYA CORPORATION

Inventor： Takuya Funazuka ,  Masaharu Shomura

IPC: B01L1/04 ,  B25J21/02 ,  A61L2/20 ,  A61L2/24 ,  C12M1/12

CPC classification number: B01L1/04 ,  A61L2/208 ,  A61L2/24 ,  A61L2202/122 ,  B01L2200/02 ,  B01L2200/025 ,  B01L2200/141 ,  B01L2200/145 ,  B01L2300/048 ,  B25J21/02 ,  C12M37/00

Abstract: An aseptic manipulation system comprises first and second operation chambers, an aseptic manipulation chamber, and a control unit. The control unit controls the ventilation of the first operation chamber for more than a first specified number of times, after an object is introduced into the first operation chamber, and ventilates the second operation chamber for more than a second specified number of times that is greater than the first specified number of times, after the object is transferred into the second operation chamber from the first chamber.

公开(公告)号：US20170275581A1

公开(公告)日：2017-09-28

申请号：US15450344

申请日：2017-03-06

Applicant: SHIBUYA CORPORATION

Inventor： Tetsuya NISHIMURA ,  Katsuki HASHIMOTO ,  Kazuhito TANIMOTO

IPC: C12M1/12 ,  C12M1/00 ,  A61L2/20

CPC classification number: C12M37/00 ,  A61L2/208 ,  A61L2202/121 ,  B01L1/02 ,  C12M23/06 ,  C12M23/58 ,  C12M29/00 ,  C12M37/04 ,  C12M41/14 ,  C12M47/16

Abstract: An isolator system 1 includes: a main isolator 3 in which an aseptic state is maintained and which is for performing an aseptic operation; an incubator 4 in which the aseptic state is maintained and which is connected to the main isolator 3 and is for culturing cells and the like; decontamination means 35 for decontaminating the inside of the main isolator 3; and a decontamination station 9 that decontaminates the inside of the incubator 4. The isolator system 1 further includes a blocking member 30 for sealing a connection port 13 from the outside, the port being provided in the main isolator 3 and being for connection with the incubator 4. When the inside of the main isolator 3 is decontaminated, the connection port 13 is sealed from the outside with the blocking member 30. The isolator system that can efficiently decontaminate the main isolator and the subisolator connected to this main isolator can be provided.

公开(公告)号：US20170137770A1

公开(公告)日：2017-05-18

申请号：US15322831

申请日：2015-06-12

Applicant: SHIBUYA CORPORATION

Inventor： Masahiro SAKAMOTO ,  Takeshi YAMAMORI

IPC: C12M1/12 ,  C12M1/00

CPC classification number: C12M37/00 ,  C12M29/14

Abstract: A culturing device configured such that an isolator 2 has at least two communication ports 2dA and 2dB, and such that an incubator 4 is connected to each of the communication ports via a connecting member 114 (connection means 111).In the state where the work chamber 2a and the inside of the incubator 4 can be made to communicate with each other by opening the one communication port 2dA and a carrying-in-and-out port 4d of the incubator 4, which carrying-in-and-out port 4d is made to communicate with the communication port 2dA, the other communication port 2dB and the carrying-in-and-out port 4d of another incubator 4 are closed, and decontamination gas is supplied into the decontamination space S formed inside the connecting member to thereby decontaminate a portion exposed to the decontamination space.Thereby, the cultivating operation can be efficiently performed.

公开(公告)号：US12139353B2

公开(公告)日：2024-11-12

申请号：US18326088

申请日：2023-05-31

Applicant: SHIBUYA CORPORATION

Inventor： Masato Ohta ,  Takashi Miyazaki ,  Yusuke Shimizu

IPC: B65G54/02 ,  B65G41/00 ,  H02K41/03

Abstract: An article conveyance apparatus conveys containers with carriers moved by a linear driving apparatus. The article conveyance apparatus includes a first upper side linear conveyance rail, a second lower side linear conveyance rail, a first delivery unit that is inverted while holding the carriers to deliver the carriers from a downstream end of the first conveyance rail to an upstream end of the second conveyance rail. A second delivery unit that is inverted while holding the plurality of carriers, delivers the carriers from a downstream end of the second conveyance rail to an upstream end of the first conveyance rail. An interval between the first conveyance rail (forward path) and the second conveyance rail (return path) is reduced as compared with an existing article conveyance apparatus.

公开(公告)号：US11926480B2

公开(公告)日：2024-03-12

申请号：US17935288

申请日：2022-09-26

Applicant: SHIBUYA CORPORATION

Inventor： Shun Okuhata ,  Masaharu Kawahara ,  Koji Kaya

IPC: B65G33/04 ,  B65G47/84

CPC classification number: B65G33/04 ,  B65G47/846 ,  B65G2201/0244

Abstract: A container supplying apparatus includes a supply conveyer conveying containers and a screw engaging with the containers on the supply conveyer and conveying the containers to a downstream side. The screw is divided into an upstream screw and a downstream screw rotationally driven by different servomotors. In a case where no container is supplied to a specific bottle table of a weighing and filling apparatus, the upstream screw is decelerated and is then accelerated relative to the downstream screw. As a result, an interval of the successive containers is expanded, and a large interval is maintained therebetween. This supplies no container to the specific bottle table of the weighing and filling apparatus.

公开(公告)号：US20230218792A1

公开(公告)日：2023-07-13

申请号：US18152758

申请日：2023-01-11

Applicant: SHIBUYA CORPORATION

Inventor： NAOYA WASHI

IPC: A61L2/24 ,  A61L2/20

CPC classification number: A61L2/24 ,  A61L2/20

Abstract: A vessel sterilizer includes a gripper which is configured to hold a vessel having an opening facing upward, the endless conveyor being configured to move the gripper in a conveyance direction along a conveyance rout; a nozzle provided on the conveyance rout and configured to inject sterilizing gas from a spout provided at a bottom end of the nozzle toward the opening of the vessel to supply the sterilizing gas into the vessel; and a swing mechanism configured to horizontally swing the gripper forward in the conveyance direction when the vessel held by the gripper approaches the nozzle along the conveyance rout and configured to horizontally swing the gripper rearward in the conveyance direction when the vessel held by the gripper moves away from the nozzle.