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公开(公告)号：US20240154117A1
公开(公告)日：2024-05-09
申请号：US18281024
申请日：2022-03-02
CPC分类号： H01M4/5825 , C01B25/45 , H01M4/366 , H01M10/36 , H01M2004/027
摘要： Provided are a sodium titanium phosphate salt and, additionally, at least one of a negative electrode active material that gives a sodium secondary battery having superior power characteristics as compared to conventional aqueous sodium secondary batteries and a sodium secondary battery including such a negative electrode active material. In particular, provided is a negative electrode active material that gives an aqueous sodium secondary battery having superior power characteristics as compared to conventional aqueous sodium secondary batteries including NASICON type NaTi2(PO4)3 as a negative electrode active material.
A sodium titanium phosphate salt represented by the general formula Na1+xTi2(PO4)3 (where 0≤x≤2) includes a surface layer containing Na5Ti(PO4)3.-
公开(公告)号：US20240052333A1
公开(公告)日：2024-02-15
申请号：US18271132
申请日：2021-12-28
申请人： YAMAGUCHI UNIVERSITY
CPC分类号： C12N9/90 , C12N11/02 , C12P19/02 , C12Y503/01007
摘要： The present invention has an object to provide a D-mannose isomerase of membrane-bound form having the optimal reaction pH in acidic region.
The membrane-bound D-mannose isomerase derived from acetic acid bacteria is produced. The acetic acid bacteria are preferably belong to the genera of Acetobacter, Gluconobacter, or Gluconacetobacter. Furthermore, the membrane-bound D-mannose isomerase from the acetic acid bacteria is used to produce D-fructose from D-mannose.-
公开(公告)号：US20230322898A1
公开(公告)日：2023-10-12
申请号：US18018807
申请日：2021-07-30
发明人： Tomoyuki Igawa , Mika Sakurai , Takashi Suzuki , Kanako Tatsumi , Shun Shimizu , Koji Tamada , Yukimi Sakoda
IPC分类号： C07K16/30 , C12N15/86 , A61P35/00 , C07K14/725 , C07K16/28 , C07K14/705 , A61K39/00
CPC分类号： C07K14/70578 , A61K39/4611 , A61K39/4637 , A61K39/464429 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K16/2818 , C07K16/283 , C07K16/2866 , C07K16/2878 , C07K16/303 , C12N15/86 , A61K2039/505 , A61K2239/22 , C07K2317/31 , C07K2317/732 , C07K2317/75 , C07K2319/02 , C07K2319/33 , C12N2740/15043
摘要： The present invention provides a pharmaceutical composition comprising cells expressing a chimeric receptor, for use in combination with administration of an antigen-binding molecule, wherein the chimeric receptor comprises an extracellular domain, the extracellular domain comprises an extracellular domain of an immunoreceptor, an extracellular domain variant of an immunoreceptor, or a portion thereof, and the antigen-binding molecule is a multispecific antigen-binding molecule having a target antigen recognition site and an immunoreceptor recognition site which recognizes the immunoreceptor.
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公开(公告)号：US20230280277A1
公开(公告)日：2023-09-07
申请号：US18315455
申请日：2023-05-10
CPC分类号： G01N21/67 , G01M3/40 , G01N33/005
摘要： An elongated ferromagnetic anodic electrode is fixed to a tightly closable pipe shape vacuum casing so as to extend within the casing as a cantilever and magnetic field applying module is disposed so as to concentrate magnetic field at a tip side position of the ferromagnetic anodic electrode in an area of discharge optical emission when a high voltage is applied between the anodic electrode and the vacuum casing as a cathode electrode. In addition, a vacuum casing can be formed with a ferromagnetic and soft magnetic material for magnetic flux to be permeable well, or a tip side alone of an anodic electrode rather than the anodic electrode itself can be formed with a ferromagnetic material, or a ferromagnetic member can be disposed at a near position of an anodic electrode, so as to concentrate magnetic field in a vicinity of a tip of an anodic electrode.
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公开(公告)号：US11730718B2
公开(公告)日：2023-08-22
申请号：US16893120
申请日：2020-06-04
申请人： Yamaguchi University
发明人： Kazuhiro Kimura
CPC分类号： A61K31/415 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K9/205 , A61K9/2018 , A61K47/26 , A61K47/44
摘要： The present invention addresses the problem of providing an inhibitor for retinochoroidal disorders, in particular, an inhibitor for retinochoroidal scar formation and retinochoroidal atrophy in an epiretinal, intraretinal or subretinal tissue. This problem can be solved by preparing an inhibitor for retinochoroidal disorders which comprises, as an active ingredient, (E)-4-(2-{3-[(1H-pyrazol-1-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl}vinyl)benzoic acid, an ester thereof or a salt of the same. The inhibitor for retinochoroidal disorders can inhibit collagen atrophy of retinal pigment epithelium cells, fibroblasts, glial cells and the like and thus inhibit retinochoroidal disorders.
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公开(公告)号：US20230255937A1
公开(公告)日：2023-08-17
申请号：US17939198
申请日：2022-09-07
申请人： YAMAGUCHI UNIVERSITY
发明人： Kazuhiro KIMURA
IPC分类号： A61K31/415 , A61K31/192 , A61K31/196 , A61K9/00 , A61K9/06 , A61K47/26
CPC分类号： A61K31/415 , A61K31/192 , A61K31/196 , A61K9/0048 , A61K9/06 , A61K47/26
摘要： The present invention addresses the problem of providing a novel therapeutic agent for keratoconjunctive disorders. As a means for solving the problem, a therapeutic agent for keratoconjunctive disorders which contains a RARγ agonist as an active ingredient is provided. The therapeutic agent exhibits an excellent ameliorating effect in a keratoconjunctive disorder model, and is therefore useful as a therapeutic agent for keratoconjunctive disorders such as corneal ulcer, corneal epithelial abrasion, keratitis, dry eye, conjunctivitis, chronic superficial keratitis, corneal erosion, persistent corneal disorders, superficial punctate keratopathy, corneal epithelial defects, conjunctival epithelial defects, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, filamentary keratoconjunctivitis, infectious keratitis, noninfectious keratitis, infectious conjunctivitis and noninfectious conjunctivitis. The therapeutic agent is also useful as a therapeutic agent for corneal scarring and conjunctival scarring both associated with keratoconjunctive disorders.
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7.发明授权公开(公告)号：US11337997B2
公开(公告)日：2022-05-24
申请号：US16084503
申请日：2017-03-15
申请人： YAMAGUCHI UNIVERSITY
发明人： Koji Tamada , Yukimi Sakoda , Keishi Adachi
IPC分类号： A61K35/17 , C12N5/10 , C12N15/09 , A61K39/00 , C07K14/54 , C07K14/725 , C12N5/0783 , C12N15/79
摘要： It is to provide an immunocompetent cell that expresses regulatory factors of immunocompetent cell immune function and possesses all of proliferative potential, viability, and the ability to accumulate a T cell, and an expression vector of regulatory factors of immune function for generating the immunocompetent cell. An immunocompetent cell expressing a cell surface molecule specifically recognizing a cancer antigen, interleukin 7 (IL-7), and CCL19 is generated. Preferably, the cell surface molecule specifically recognizing a cancer antigen is T cell receptor specifically recognizing the cancer antigen, and the immunocompetent cell is a T cell.
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公开(公告)号：US11272907B2
公开(公告)日：2022-03-15
申请号：US16320312
申请日：2017-07-26
摘要： A feces collection sheet (S), which has a cylindrical shape and includes: an upper sheet (1) having a feces receiving portion (2) in a center of the upper sheet (1); and a lower sheet (9), which is provided so as to extend from both of a right-side edge portion and a left-side edge portion of the upper sheet (1) and is configured to define a gap with the upper sheet (1) to allow insertion of a toilet seat therethrough. The upper sheet (1) and the lower sheet (9) are made of a material having a water-soluble material property. The upper sheet (1) has a folded piece portion (10) adapted to be unfolded to enable the feces receiving portion (2) to form a three-dimensional shape that bulges toward the lower sheet (9).
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公开(公告)号：US11111526B2
公开(公告)日：2021-09-07
申请号：US16322363
申请日：2017-08-02
发明人： Toshiya Tsuda , Shuichi Kamei , Mitsuyoshi Oba , Hirofumi Yamano , Ryouichi Tsunedomi , Shoichi Hazama , Hiroaki Nagano
IPC分类号： C12Q1/68 , C12Q1/6832 , C07H21/00 , C12N15/09 , C12M1/00
摘要： In the case of using a blocking nucleic acid to prevent non-specific hybridization of a target nucleic acid with a nucleic acid probe, further excellent efficiency of detecting the target nucleic acid is achieved. A buffer composition used in hybridization of a target nucleic acid with a nucleic acid probe, wherein the buffer composition for hybridization contains a blocking nucleic acid comprising a nucleotide sequence complementary to a region comprising at least a non-detection target nucleotide in a non-target nucleic acid, in a concentration of one or more times higher than the concentration of a nucleic acid in a nucleic acid mixture consisting of the target nucleic acid and the non-target nucleic acid.
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公开(公告)号：US20210092823A1
公开(公告)日：2021-03-25
申请号：US16772015
申请日：2018-12-11
摘要： An X-ray tube, including: an envelope (11) that holds inside thereof at a predetermined pressure; a filament (12) for emitting electrons and a focus electrode (13) provided in the envelope: and a target (15) for generating X-ray provided in the envelope facing to the filament (12) and the focus electrode (13), wherein the envelope (11) has an envelope body (11a) and an X-ray window portion (16) having a higher X-rays transmissivity and a higher electric conductivity than the envelope body (11a), when the X-ray window portion (16) or the anode (14) is set to a lower electric potential than both of an electric potential of the anode (14) or the X-ray window portion (16) and an electric potential of the filament (12) and the focus electrode (13), detection of at least one of an ion current (Ii) or an electron current (Ie) through the X-ray window portion (16) or the anode (14) is possible.
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