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31.发明授权Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support 有权从固体支持物制备高度官能化的1,3-二氨基 - 丙-2-醇的方法公开(公告)号：US08501937B2
公开(公告)日：2013-08-06
申请号：US13432049
申请日：2012-03-28
Applicant: Steven J. Coats , Dennis J. Hlasta , Mark J. Schulz
Inventor： Steven J. Coats , Dennis J. Hlasta , Mark J. Schulz
IPC: C07D265/30 , C07D413/00 , C07D221/00 , C07D215/00 , C07D211/00 , C07D211/32 , C07D207/00 , C07D307/00 , C07D315/00 , C07D303/00
CPC classification number: C07C315/04 , C07B2200/11 , C07C233/37 , C07C233/40 , C07C233/62 , C07C233/78 , C07C235/50 , C07C235/84 , C07C237/20 , C07C237/22 , C07C237/34 , C07C271/20 , C07C303/40 , C07C319/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/50 , C07D213/38 , C07D215/54 , C07D295/13 , C07D307/22 , C07D333/20 , C40B40/04 , C40B50/14 , C07C317/44 , C07C323/60 , C07C311/37
Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
Abstract translation: 本发明涉及合成羟乙基氨基酰胺的化合物和方法及其在治疗天冬氨酰蛋白酶介导的疾病和病症中的用途。
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公开(公告)号：US08426429B2
公开(公告)日：2013-04-23
申请号：US11197608
申请日：2005-08-04
Applicant: Ellen Baxter , Robert Boyd , Steven J. Coats , Alfonzo D. Jordan , Allen B. Reitz , Charles H. Reynolds , Mark Schulz , Malcolm Scott
Inventor： Ellen Baxter , Robert Boyd , Steven J. Coats , Alfonzo D. Jordan , Allen B. Reitz , Charles H. Reynolds , Mark Schulz , Malcolm Scott
IPC: A61K31/517 , C07D239/88 , C07D239/94 , C07D401/06 , A61K31/535 , C07D265/30
CPC classification number: C07D215/227 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/06
Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.
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33.发明申请PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS 有权用于治疗癌症和病毒感染的磷酸核苷一磷酸腺苷公开(公告)号：US20120040924A1
公开(公告)日：2012-02-16
申请号：US13144718
申请日：2010-02-09
Applicant: Jong Hyun Cho , Steven J. Coats , Raymond F. Schinazi , Hongwang Zhang , Longhu Zhou
Inventor： Jong Hyun Cho , Steven J. Coats , Raymond F. Schinazi , Hongwang Zhang , Longhu Zhou
IPC: A61K31/7076 , C07D473/16 , A61P31/22 , A61P31/18 , A61P31/14 , C07H19/20 , A61K31/675
CPC classification number: A61K31/7076 , A61K31/675 , A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/708 , A61K45/06 , C07D473/16 , C07H19/173 , C07H19/20 , Y02A50/385 , Y02A50/387 , Y02A50/393 , A61K2300/00
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.
Abstract translation: 本发明涉及用于治疗或预防癌症和病毒感染的化合物，组合物和方法，特别是人类患者中的HIV，HCV，诺如病毒，Saporovirus，HSV-1，HSV-2，登革热病毒，黄热病和HBV 或其他动物宿主。 化合物是某些6-取代嘌呤单磷酸酯及其药学上可接受的盐，前药和其它衍生物。 特别地，这些化合物显示针对HIV-1，HIV-2，HCV，诺如病毒，Saporovirus，HSV-1，HSV-2，登革热病毒，黄热病和HBV的有效的抗病毒活性。
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公开(公告)号：US20120028997A1
公开(公告)日：2012-02-02
申请号：US12970461
申请日：2010-12-16
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC: A61K31/515 , C07D401/06 , C07D403/12 , A61P1/12 , A61P1/00 , A61P35/00 , A61P29/00 , C07D401/12 , A61K31/513
CPC classification number: C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
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公开(公告)号：US20100093709A1
公开(公告)日：2010-04-15
申请号：US12622548
申请日：2009-11-20
Applicant: Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
Inventor： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC: A61K31/5415 , C07D413/02 , C07D413/14 , C07D417/14 , A61K31/538
CPC classification number: C07D451/04
Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
Abstract translation: 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环δ-阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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Patent Agency Ranking
公开(公告)号：US20080318937A1
公开(公告)日：2008-12-25
申请号：US12196865
申请日：2008-08-22
Applicant: Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
Inventor： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC: A61K31/5415 , C07D417/14 , C07D413/14 , A61K31/538 , A61P25/00
CPC classification number: C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
Abstract translation: 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20190077797A1
公开(公告)日：2019-03-14
申请号：US15772294
申请日：2016-10-31
Applicant: Ozkan SARI , Coralie DE SCHUTTER , Jong-Hyun CHO , Longhu ZHOU , Hongwang ZANG , Franck AMBLARD , Steven J. COATS , Raymond F. SCHINAZI
Inventor： Ozkan SARI , Coralie DE SCHUTTER , Jong-Hyun CHO , Longhu ZHOU , Hongwang ZANG , Franck AMBLARD , Steven J. COATS , Raymond F. SCHINAZI
IPC: C07D413/06 , C07D317/30 , C07D307/33
Abstract: Methods for forming 2-bromo, 2-fluoro ribofuranose intermediates and 2-chloro, 2-fluoro ribofuranose intermediates for use in preparing antiviral nucleosides are disclosed. Methods for forming nucleosides, and nucleoside prodrugs, using the intermediates, are also disclosed. The methods all produce intermediates, and the resulting nucleosides and prodrugs thereof, wherein the chirality of the carbon at the 2-position is controlled. In some embodiments, the chemistry involves using chiral auxiliaries, such as (R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde, and in other embodiments, the chemistry involves using chiral starting materials, such as D-xylose.
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公开(公告)号：US07902358B2
公开(公告)日：2011-03-08
申请号：US11647091
申请日：2006-12-28
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC: C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , A61K31/506 , A61P1/00 , A61P1/06
CPC classification number: C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
Abstract translation: 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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公开(公告)号：US20080287445A1
公开(公告)日：2008-11-20
申请号：US11646957
申请日：2006-12-28
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC: A61K31/505 , A61K31/435 , A61P1/00 , A61K31/53
CPC classification number: A61K31/506 , A61K31/53
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.
Abstract translation: 本发明涉及某些新的式（I）化合物：以及用于治疗促动蛋白原2或原激素2受体介导的病症的方法。
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公开(公告)号：US20080269225A1
公开(公告)日：2008-10-30
申请号：US11647091
申请日：2006-12-28
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC: A61K31/53 , C07D405/12 , A61P29/00 , A61P1/00
CPC classification number: C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
Abstract translation: 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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