公开(公告)号：US20090117594A1

公开(公告)日：2009-05-07

申请号：US12293992

申请日：2007-03-28

Applicant: Shinya Ogasawara ,  Shuhei Miura ,  Akihiko Saito ,  Tetsuro Takeda

Inventor： Shinya Ogasawara ,  Shuhei Miura ,  Akihiko Saito ,  Tetsuro Takeda

IPC: G01N33/53 ,  G01N33/566 ,  C12Q1/37 ,  C12Q1/40

CPC classification number: G01N33/92 ,  C07K16/28 ,  G01N33/6893 ,  G01N2800/00 ,  G01N2800/347

Abstract: This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.

Abstract translation: 本发明提供了一种用于测量人类巨蛋白的方法，其可以在比常规技术可能的更短的时间内以更简单的方式进行，并且还可以定量人巨蛋白。 本发明还提供了能够以早期阶段以现场方式诊断功能性疾病的方法，所述功能性疾病特异于细胞，组织或器官。 人巨蛋白的测定能够检测观察到巨蛋白表达的器官中的疾病。

公开(公告)号：US07506346B2

公开(公告)日：2009-03-17

申请号：US10576169

申请日：2004-10-18

Applicant: Shinya Ogasawara ,  Shingo Kage ,  Yukihiro Araki ,  Nobuyuki Miroku

Inventor： Shinya Ogasawara ,  Shingo Kage ,  Yukihiro Araki ,  Nobuyuki Miroku

IPC: G11B17/04

CPC classification number: G11B17/051 ,  G11B17/0286 ,  G11B33/121

Abstract: The present invention provides a highly reliable disk apparatus which is reduced in size, thickness and weight, and which can surely prevent the double insertion of disk-shaped recording media with a simple structure to thereby prevent a contact between each of the disk-shaped recording media. In the disk apparatus of the present invention, a disk guide is rotatably held in the proximity of an opening for inserting and ejecting a disk-shaped recording medium, which is formed in the stationary frame fixed to the casing, and the disk guide leads the disk-shaped recording medium to the inserting and ejecting operations and also closes at least a part of the above opening.

Abstract translation: 本发明提供了一种高可靠性的盘装置，其尺寸，厚度和重量都减小，并且可以确实地防止以简单结构双重插入盘形记录介质，从而防止每个盘形记录 媒体。 在本发明的盘装置中，盘引导件可旋转地保持在用于插入和弹出形成在固定到壳体上的固定框架中的盘形记录介质的开口附近，并且盘引导件引导 盘状记录介质到插入和排出操作，并且还关闭上述开口的至少一部分。

公开(公告)号：US20080191124A1

公开(公告)日：2008-08-14

申请号：US12028109

申请日：2008-02-08

Applicant: Miyoko IRIKIIN ,  Yukihiro Iwata ,  Shinya Ogasawara

Inventor： Miyoko IRIKIIN ,  Yukihiro Iwata ,  Shinya Ogasawara

IPC: H01L27/00 ,  F28F7/00

CPC classification number: H04N5/2253 ,  F28F3/02 ,  H04N9/097

Abstract: In a heat radiating member which has a contact portion to be put into contact with a solid-state image sensor fixed to a prism member, and a fin-like heat radiating portion for radiating heat, which has been transferred through the contact portion, into its surrounding gas, the contact portion and the heat radiating portion are formed from a foil member made of a high heat conductivity material. By mounting the heat radiating member on the solid-state image sensor, there is realized a heat radiating structure for cooling the solid-state image sensor while reducing external-force loads applied to the solid-state image sensor with a relatively simple structure.

Abstract translation: 在具有与固定在棱镜部件上的固体摄像元件接触的接触部分的热辐射部件和通过接触部分传送的散热用的鳍状散热部分成为 其周围的气体，接触部分和散热部分由由高导热性材料制成的箔构件形成。 通过将散热构件安装在固态图像传感器上，实现了用于冷却固态图像传感器的散热结构，同时以相对简单的结构减少施加到固态图像传感器的外力负载。

公开(公告)号：US06783435B1

公开(公告)日：2004-08-31

申请号：US10130776

申请日：2002-05-21

Applicant: Shinya Ogasawara ,  Mitsuhisa Fujiki ,  Satoshi Yamabayashi ,  Tetsuya Okana

Inventor： Shinya Ogasawara ,  Mitsuhisa Fujiki ,  Satoshi Yamabayashi ,  Tetsuya Okana

IPC: B24B100

CPC classification number: G11B5/531 ,  G11B5/1335 ,  G11B5/1871

Abstract: A magnetic head is manufactured by grinding a head chip (2) with a gap depth (GD 1) to remove its margin (6) until the gap depth becomes a final gap depth (GD 2). The gap depth (GD 1) is 25 microns or thinner. The method increases yield and productivity in the manufacture of a high performance magnetic head with a decreased gap depth (GD 2), which satisfies the standards of both the gap depth (GD 2) and the distance between the head gap and the outermost point of the chip front.

Abstract translation: 通过研磨具有间隙深度（GD 1）的头部芯片（2）以去除其边缘（6）直到间隙深度变为最终间隙深度（GD 2）来制造磁头。 间隙深度（GD 1）为25微米或更薄。 该方法在间隙深度减小（GD 2）的高性能磁头的制造中提高了产量和生产率，其满足了间隙深度（GD 2）和磁头间隙与最外点之间的距离 芯片前端。

公开(公告)号：US06640418B2

公开(公告)日：2003-11-04

申请号：US09890476

申请日：2001-07-31

Applicant: Tetsuya Okana ,  Mitsuhisa Fujiki ,  Satoshi Yamabayashi ,  Shinya Ogasawara

Inventor： Tetsuya Okana ,  Mitsuhisa Fujiki ,  Satoshi Yamabayashi ,  Shinya Ogasawara

IPC: G11B5127

CPC classification number: G11B5/48 ,  G11B5/1871 ,  G11B5/488 ,  G11B5/4893 ,  G11B5/531 ,  G11B5/60 ,  G11B15/61 ,  G11B15/64 ,  Y10T29/49039 ,  Y10T29/4913 ,  Y10T29/49133 ,  Y10T29/49135

Abstract: In processing a head unit in which a head relative height Y is Y′ with a grinding amount &Dgr;GD of &Dgr;GD′, the relationship between distances Bo between a vertex of a curved surface as a front face of a head chip and a head gap before and after grinding the front face of the head chip and a gap depth dimension GD, is predetermined with respect to a head unit in which the head relative height is substantially equal to Y′, through which Bo1 as the value of Bo before grinding corresponding to a target value of the value of Bo after grinding is determined and used as Bo1 of the head unit in which the head relative height Y is Y′. Thus, grinding of the front face of the head chip is conducted after Bo1 corresponding to the target value is determined. Hence, a head unit with the value of Bo after grinding falling within the range of standard values can be manufactured efficiently, and accordingly the yield can be improved.

Abstract translation: 在处理头部相对高度Y为具有DeltaGD'的磨削量DeltaGD的头部单元的情况下，作为头部芯片的前表面的曲面的顶点与前面的头部间隙之间的曲面顶点之间的距离Bo之间的关系，以及 在研磨头芯片的前表面和间隙深度尺寸GD之后，相对于头部相对高度基本上等于Y'的头单元是预定的，通过该头部单元，Bo1作为磨削前的Bo值对应于 确定研磨后的Bo值的目标值，并将其用作头部相对高度Y为Y'的头部单元的Bo1。 因此，在确定与目标值对应的Bo1之后，进行头芯片的正面的磨削。 因此，可以有效地制造研磨后的Bo值在标准值的范围内的头单元，从而可以提高成品率。

公开(公告)号：US08673577B2

公开(公告)日：2014-03-18

申请号：US13579906

申请日：2011-02-24

Applicant: Masanori Hara ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

Inventor： Masanori Hara ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

IPC: G01N33/53

CPC classification number: G01N33/6893 ,  G01N2800/347

Abstract: Provided is a test method for acute kidney injury, including detecting urinary podocalyxin. According to the test method, a subject to be tested who has a higher value for the urinary podocalyxin than a reference value can be assessed to have acute kidney injury. Further, as compared to a conventional method, the test method allows acute kidney injury to be assessed accurately and non-invasively, which allows a physical burden on a patient to be reduced. Thus, the test method is useful.

Abstract translation: 提供急性肾损伤的检测方法，包括检测尿球蛋白。 根据测试方法，可以评估具有比参考值更高的尿球蛋白含量的被测试患者具有急性肾损伤。 此外，与常规方法相比，测试方法允许精确和非侵入性地评估急性肾损伤，这允许减少患者的身体负担。 因此，测试方法是有用的。

公开(公告)号：US08628930B2

公开(公告)日：2014-01-14

申请号：US13266397

申请日：2010-04-27

Applicant: Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Shinya Ogasawara ,  Hiroyuki Kurosawa ,  Yoshiaki Hirayama

Inventor： Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Shinya Ogasawara ,  Hiroyuki Kurosawa ,  Yoshiaki Hirayama

IPC: G01N33/53

CPC classification number: G01N33/6872 ,  G01N2800/347

Abstract: This invention provides a simple means for detecting a renal disorder, a diagnostic marker for a renal disorder that enables prognostic prediction of a renal disorder (e.g., diabetic nephropathy and IgA nephropathy) and evaluation of the degree of nephropathy at the phase of stage-II diabetic nephropathy by measuring the megalin level in urine associated with a renal disorder used for the detection means, and use of such marker. The invention also provides the use of human megalin obtained from the urine sample of a subject as a marker for detecting a renal disorder.

Abstract translation: 本发明提供了一种用于检测肾脏疾病的简单方法，一种能够预测肾病（例如，糖尿病性肾病和IgA肾病）的肾病的诊断标志物，并评估II期阶段的肾病程度 通过测量与用于检测手段的肾脏疾病相关的尿液中的巨蛋白水平，以及使用这种标记物，糖尿病性肾病。 本发明还提供了从受试者的尿样获得的人巨蛋白作为检测肾病的标记物的用途。

公开(公告)号：US20120040374A1

公开(公告)日：2012-02-16

申请号：US13266411

申请日：2010-04-27

Applicant: Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Shinya Ogasawara ,  Hiroyuki Kurosawa ,  Yoshiaki Hirayama

Inventor： Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Shinya Ogasawara ,  Hiroyuki Kurosawa ,  Yoshiaki Hirayama

IPC: G01N21/76 ,  C07K14/705 ,  G01N33/577 ,  G01N33/566

CPC classification number: G01N33/92 ,  G01N2800/347

Abstract: This invention provides a diagnostic kit and a diagnostic marker used for diagnosing a renal disease. This invention also provides a method for detecting a renal disease comprising measuring at least one type of human megalin existing in urine selected from among full-length human megalin and human megalin fragments of (i) to (iii): (i) full-length human megalin; (ii) a human megalin endodomain fragment lacking a human megalin ectodomain; and (iii) a human megalin ectodomain fragment lacking a human megalin endodomain.

Abstract translation: 本发明提供了用于诊断肾脏疾病的诊断试剂盒和诊断标记。 本发明还提供了一种用于检测肾脏疾病的方法，包括测量存在于选自全身人巨蛋白和（i）至（iii））的人巨蛋白片段中的至少一种类型的人巨蛋白：（i）全长 人巨蛋 （ii）缺乏人巨蛋白胞外域的人巨蛋白胞质内结构域片段; 和（iii）缺乏人巨蛋白结构域的人巨蛋白胞外域片段。

公开(公告)号：US07955809B2

公开(公告)日：2011-06-07

申请号：US12293992

申请日：2007-03-28

Applicant: Shinya Ogasawara ,  Shuhei Miura ,  Akihiko Saito ,  Tetsuro Takeda

Inventor： Shinya Ogasawara ,  Shuhei Miura ,  Akihiko Saito ,  Tetsuro Takeda

IPC: G01N33/53

CPC classification number: G01N33/92 ,  C07K16/28 ,  G01N33/6893 ,  G01N2800/00 ,  G01N2800/347

Abstract: This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.

Abstract translation: 本发明提供了一种用于测量人类巨蛋白的方法，其可以在比常规技术可能的更短的时间内以更简单的方式进行，并且还可以定量人巨蛋白。 本发明还提供了能够以早期阶段以现场方式诊断功能性疾病的方法，所述功能性疾病特异于细胞，组织或器官。 人巨蛋白的测定能够检测观察到巨蛋白表达的器官中的疾病。

公开(公告)号：US20100233738A1

公开(公告)日：2010-09-16

申请号：US12680479

申请日：2008-09-26

Applicant: Masanori Hara ,  Akihiko Saito ,  Shinya Ogasawara ,  Yoshiaki Hirayama ,  Hiroyuki Kurosawa

Inventor： Masanori Hara ,  Akihiko Saito ,  Shinya Ogasawara ,  Yoshiaki Hirayama ,  Hiroyuki Kurosawa

IPC: G01N33/53 ,  G01N33/00

CPC classification number: G01N33/6827 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/108331

Abstract: The present invention is intended to develop a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The present invention provides: a urine pretreatment agent for urinary protein quantitation, comprising a buffer, a chelating agent, and a surfactant; a urine pretreatment method comprising a step of mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and a urinary protein quantitation method comprising steps of: mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and then measuring the protein concentration.

Abstract translation: 本发明旨在开发尿液预处理剂，尿预处理方法和尿蛋白定量方法，其减少或消除尿pH变化的影响，消除尿无机盐沉淀物的影响和溶解膜蛋白。 本发明提供了一种尿蛋白定量尿预处理剂，其包含缓冲液，螯合剂和表面活性剂; 尿预处理方法包括将10〜1000质量份本发明的尿预处理剂与100质量份的尿混合的步骤; 和尿蛋白定量方法，其包括以下步骤：将10〜1000质量份的本发明的尿预处理剂与100质量份的尿混合; 然后测量蛋白质浓度。