公开(公告)号：US20120164667A1

公开(公告)日：2012-06-28

申请号：US13377509

申请日：2010-06-09

申请人： Masanori Hara ,  Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

发明人： Masanori Hara ,  Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

IPC分类号： G01N33/566 ,  G01N33/577 ,  G01N21/59 ,  C07K16/18

CPC分类号： G01N33/6893 ,  G01N2800/042 ,  G01N2800/347

摘要： Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin.

摘要翻译： 提供了与常规方法相比较，用于早期检测糖尿病肾病的测试方法。 具体提供的是：糖尿病肾病的检测方法，包括检测尿球蛋白; 测试方法，还包括评估至少I期的糖尿病肾病; 用于测试方法的测试试剂; 和用于测试方法的测试试剂盒。 本发明是基于一个发现，尿囊球蛋白反映与尿白蛋白相比，在早期阶段具有高灵敏度的糖尿病肾病的发展和状况。

公开(公告)号：US20120164662A1

公开(公告)日：2012-06-28

申请号：US13377510

申请日：2010-06-09

申请人： Masanori Hara ,  Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

发明人： Masanori Hara ,  Akihiko Saito ,  Yasuhiko Tomino ,  Katsuhiko Asanuma ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

IPC分类号： G01N33/566 ,  C07K16/18

CPC分类号： G01N33/6893 ,  G01N2333/78 ,  G01N2800/347 ,  G01N2800/52

摘要： Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly.

摘要翻译： 提供了一种用于评估被检对象的患者肾活检的必要性的测试方法，其被怀疑患有肾脏疾病。 具体提供了肾脏疾病的检测方法，包括使用尿球蛋白胨和一种或多种组合的附加标记物，以及用于测试方法的测试试剂和用于测试方法的测试试剂盒。 本发明允许在常规测试方法中即使对于预后不良的患者进行差异性鉴别，也没有公开的发现，因此可以评估肾脏疾病，评估肾活检的必要性，预后预测和 喜欢被完全执行。

公开(公告)号：US08105840B2

公开(公告)日：2012-01-31

申请号：US12680479

申请日：2008-09-26

申请人： Masanori Hara ,  Akihiko Saito ,  Shinya Ogasawara ,  Yoshiaki Hirayama ,  Hiroyuki Kurosawa

发明人： Masanori Hara ,  Akihiko Saito ,  Shinya Ogasawara ,  Yoshiaki Hirayama ,  Hiroyuki Kurosawa

IPC分类号： G01N33/68 ,  G01N33/48

CPC分类号： G01N33/6827 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/108331

摘要： Described are a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The urine pretreatment agent for urinary protein quantitation, includes a buffer, a chelating agent, and a surfactant; the urine pretreatment method includes a step of mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and the urinary protein quantitation method includes steps of: mixing 10 to 1000 parts by mass of the urine pretreatment agent with 100 parts by mass of urine; and then measuring the protein concentration.

摘要翻译： 描述了尿液预处理剂，尿预处理方法和尿蛋白定量方法，其减少或消除尿pH变化的影响，消除尿无机盐沉淀物的影响和溶解膜蛋白。 用于尿蛋白定量的尿预处理剂包括缓冲液，螯合剂和表面活性剂; 尿预处理方法包括将10〜1000质量份本发明的尿预处理剂与尿液100质量份混合的步骤; 尿蛋白定量方法包括以下步骤：将10〜1000质量份的尿预处理剂与100质量份的尿混合; 然后测量蛋白质浓度。

公开(公告)号：US08673577B2

公开(公告)日：2014-03-18

申请号：US13579906

申请日：2011-02-24

申请人： Masanori Hara ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

发明人： Masanori Hara ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2800/347

摘要： Provided is a test method for acute kidney injury, including detecting urinary podocalyxin. According to the test method, a subject to be tested who has a higher value for the urinary podocalyxin than a reference value can be assessed to have acute kidney injury. Further, as compared to a conventional method, the test method allows acute kidney injury to be assessed accurately and non-invasively, which allows a physical burden on a patient to be reduced. Thus, the test method is useful.

摘要翻译： 提供急性肾损伤的检测方法，包括检测尿球蛋白。 根据测试方法，可以评估具有比参考值更高的尿球蛋白含量的被测试患者具有急性肾损伤。 此外，与常规方法相比，测试方法允许精确和非侵入性地评估急性肾损伤，这允许减少患者的身体负担。 因此，测试方法是有用的。

公开(公告)号：US20100233738A1

公开(公告)日：2010-09-16

申请号：US12680479

申请日：2008-09-26

申请人： Masanori Hara ,  Akihiko Saito ,  Shinya Ogasawara ,  Yoshiaki Hirayama ,  Hiroyuki Kurosawa

发明人： Masanori Hara ,  Akihiko Saito ,  Shinya Ogasawara ,  Yoshiaki Hirayama ,  Hiroyuki Kurosawa

IPC分类号： G01N33/53 ,  G01N33/00

CPC分类号： G01N33/6827 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/108331

摘要： The present invention is intended to develop a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The present invention provides: a urine pretreatment agent for urinary protein quantitation, comprising a buffer, a chelating agent, and a surfactant; a urine pretreatment method comprising a step of mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and a urinary protein quantitation method comprising steps of: mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and then measuring the protein concentration.

摘要翻译： 本发明旨在开发尿液预处理剂，尿预处理方法和尿蛋白定量方法，其减少或消除尿pH变化的影响，消除尿无机盐沉淀物的影响和溶解膜蛋白。 本发明提供了一种尿蛋白定量尿预处理剂，其包含缓冲液，螯合剂和表面活性剂; 尿预处理方法包括将10〜1000质量份本发明的尿预处理剂与100质量份的尿混合的步骤; 和尿蛋白定量方法，其包括以下步骤：将10〜1000质量份的本发明的尿预处理剂与100质量份的尿混合; 然后测量蛋白质浓度。

公开(公告)号：US20120322087A1

公开(公告)日：2012-12-20

申请号：US13579906

申请日：2011-02-24

申请人： Masanori Hara ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

发明人： Masanori Hara ,  Hiroyuki Kurosawa ,  Shinya Ogasawara ,  Yoshiaki Hirayama

IPC分类号： G01N33/566 ,  C07K16/28

CPC分类号： G01N33/6893 ,  G01N2800/347

摘要： Provided is a test method for acute kidney injury, including detecting urinary podocalyxin. According to the test method, a subject to be tested who has a higher value for the urinary podocalyxin than a reference value can be assessed to have acute kidney injury. Further, as compared to a conventional method, the test method allows acute kidney injury to be assessed accurately and non-invasively, which allows a physical burden on a patient to be reduced. Thus, the test method is useful.

摘要翻译： 提供急性肾损伤的检测方法，包括检测尿球蛋白。 根据测试方法，可以评估具有比参考值更高的尿球蛋白胨值的待测试对象以具有急性肾损伤。 此外，与常规方法相比，测试方法允许精确和非侵入性地评估急性肾损伤，这允许减少患者的身体负担。 因此，测试方法是有用的。

公开(公告)号：US09169543B2

公开(公告)日：2015-10-27

申请号：US12532351

申请日：2008-03-21

申请人： Masahide Kawabata ,  Seiichi Endo ,  Masanori Hara ,  Koki Otsuka

发明人： Masahide Kawabata ,  Seiichi Endo ,  Masanori Hara ,  Koki Otsuka

IPC分类号： C22C38/42 ,  C22C38/48 ,  C21D6/00 ,  C21D6/02 ,  C21D1/25

CPC分类号： C22C38/42 ,  C21D1/25 ,  C21D6/004 ,  C21D6/005 ,  C21D6/02 ,  C21D2211/004 ,  C21D2211/008 ,  C22C38/48

摘要： Precipitation-hardened, martensitic, cast stainless steel having a composition comprising, by mass, 0.08-0.18% of C, 1.5% or less of Si, 2.0% or less of Mn, 0.005-0.4% of S, 13.5-16.5% of Cr, 3.0-5.5% of Ni, 0.5-2.8% of Cu, 1.0-2.0% of Nb, and 0.12% or less of N, the amounts of C, N and Nb meeting the condition of −0.2≦9 (C %+0.86N %)−Nb %≦1.0, the rest being Fe and inevitable impurities, and having a structure in which Cu precipitates having an average particle size of 0.1-0.4 μm are dispersed in a tempered-martensite-based matrix.

摘要翻译： 沉积硬化马氏体铸造不锈钢，其组成为：将C：0.08〜0.18％，Si：1.5％以下，Mn：2.0％以下，S：0.005〜0.4％，S：13.5〜16.5％ Cr，3.0-5.5％的Ni，0.5〜2.8％的Cu，1.0〜2.0％的Nb和0.12％以下的N，满足条件为-0.2＆nlE的C，N和Nb的量为9（C ％+ 0.86N％）-Nb％＆nlE; 1.0，其余为Fe和不可避免的杂质，并且具有平均粒径为0.1〜0.4μm的Cu析出物分散在回火马氏体系基体中的结构。

公开(公告)号：US20130216106A1

公开(公告)日：2013-08-22

申请号：US13882645

申请日：2011-11-02

申请人： Masanori Hara ,  Nina Sato

发明人： Masanori Hara ,  Nina Sato

IPC分类号： G06K9/00

CPC分类号： G06K9/001 ,  G06K9/00067 ,  G06K9/036

摘要： A feature-point matching unit calculates a first matching score between first and second biological patterns, based on: first and second feature-point data indicating first and second feature-point sets of first and second ridge patterns included in first and second images of first and second biological patterns respectively, and generates a corresponding feature-point list by extracting a corresponding feature-point set being a set of corresponding feature-points between the first and second feature point sets. A non-linear image conversion unit performs a first non-linear conversion making the first image approximate to the second based on the corresponding feature-point list. A feature point matching unit calculates a second matching score between the first and second biological patterns based on the first image after the first non-linear image conversion and the second. A high matching accuracy is achieved in fingerprint or palmprint matching using a low-quality image.

摘要翻译： 特征点匹配单元基于：第一和第二特征点数据来计算第一和第二生物图案之间的第一匹配分数，第一和第二特征点数据指示包括在第一和第二图像的第一和第二图像中的第一和第二脊图案的第一和第二特征点集合 和第二生物模式，并且通过提取对应的特征点集合来生成对应的特征点集合，所述相应特征点集合是第一和第二特征点集合之间的对应特征点的集合。 非线性图像转换单元基于对应的特征点列表执行使第一图像接近第二图像的第一非线性转换。 特征点匹配单元基于第一非线性图像转换之后的第一图像和第二图像转换来计算第一和第二生物图案之间的第二匹配分数。 在使用低质量图像的指纹或掌纹匹配中实现高匹配精度。

公开(公告)号：US20130051636A1

公开(公告)日：2013-02-28

申请号：US13574198

申请日：2010-12-21

申请人： Masanori Hara ,  Hiroaki Toyama

发明人： Masanori Hara ,  Hiroaki Toyama

IPC分类号： G06K9/00

CPC分类号： G06T5/003 ,  G06K9/00067 ,  G06T2207/20192

摘要： An image processing apparatus includes: a data storage section configured to store image data as a density image containing a fingerprint or a palm print and ridge pattern direction distribution data which shows a direction distribution of a ridge pattern in a fingerprint or a palm print; a direction usage image enhancing section configured to execute ridge direction usage image enhancement processing on the density image based on the ridge pattern direction distribution data; and a direction extracting section configured to extract a first direction distribution of a first pattern which is contained in a ridge direction usage image enhanced image, from the ridge direction usage image enhanced image as a result of the ridge direction usage image enhancement processing to the density image. The direction usage image enhancing section executes first direction usage image enhancement processing on the density image based on first direction distribution data which shows a first direction distribution.

摘要翻译： 一种图像处理装置，包括：数据存储部，被配置为将图像数据存储为包含指纹或掌纹的浓度图像，以及脊图形方向分布数据，其显示指纹或掌纹中的脊图案的方向分布; 方向使用图像增强部，被配置为基于所述脊图案方向分布数据对所述浓度图像执行脊线方向使用图像增强处理; 以及方向提取部，被配置为从作为脊方向使用图像增强处理的结果的脊线方向使用图像增强图像中提取包含在脊线方向使用图像增强图像中的第一图案的第一方向分布， 图片。 方向使用图像增强部基于表示第一方向分布的第一方向分布数据对密度图像执行第一方向使用图像增强处理。

公开(公告)号：US20120057797A1

公开(公告)日：2012-03-08

申请号：US13321065

申请日：2010-05-19

申请人： Masanori Hara

发明人： Masanori Hara

IPC分类号： G06K9/40 ,  G06K9/46 ,  G06K9/56

CPC分类号： G06T5/002 ,  G06K9/00067 ,  G06K9/40 ,  G06T5/20

摘要： Disclosed is a pattern noise removal device for removing background pattern noise having periodicity from a digital image, which includes a candidate pixel extracting module for extracting candidate pixels that constitute the background pattern noise from the pixels in the image on the bases of the concentration of each of the pixels, a dot pattern feature extracting module for extracting the feature of a dot pattern formed by each of the candidate pixels and the peripheral neighborhood pixels among the extracted candidate pixels, a dot pattern area extracting module for extracting a dot pattern area including the candidate pixels of the periodicity and the neighborhood pixels, which have the feature of the dot pattern, and a periodic pattern noise removal module for removing the candidate pixels of the periodicity and the neighborhood pixels, which are included in the dot pattern area, as the background pattern noise.

摘要翻译： 公开了一种用于从数字图像中去除具有周期性的背景图案噪声的图案噪声去除装置，其包括候选像素提取模块，用于基于每个图像的浓度从图像中的像素中提取构成背景图案噪声的候选像素 的点图案特征提取模块，用于提取由所提取的候选像素中的每个候选像素和外围邻域像素形成的点图案的特征;点阵图区域提取模块，用于提取包括 具有点图案的特征的周期性的候选像素和相邻像素，以及用于将包括在点图案区域中的周期性的候选像素和邻近像素的周期性图案噪声去除模块作为 背景图案噪音。