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公开(公告)号：US09758831B2
公开(公告)日：2017-09-12
申请号：US14703942
申请日：2015-05-05
Inventor： Anat Achiron , Michael Gurevich
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/166
Abstract: Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.
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公开(公告)号：US20170224780A1
公开(公告)日：2017-08-10
申请号：US15581001
申请日：2017-04-28
Inventor： Dror MEIROW , Hadassa RONESS
IPC: A61K38/22 , A61B17/435 , A61K35/54
CPC classification number: A61K38/22 , A61B17/435 , A61K35/54 , A61K45/06 , A61P15/00 , A61P15/18 , A61K2300/00
Abstract: Provided are compositions and methods for preventing premature follicle activation and loss induced by transplantation of ovaries or tissues derived from ovaries, thereby preserving fertility in a subject.
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公开(公告)号：US09688697B2
公开(公告)日：2017-06-27
申请号：US14742907
申请日：2015-06-18
Inventor： Anat Achiron , Roi Mashiach , Michael Gurevich
IPC: A61K31/55 , C07D471/12 , C07D513/14 , A61K31/551 , C12Q1/68
CPC classification number: A61K31/551 , C07D513/14 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , Y02A50/414
Abstract: Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.
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公开(公告)号：US20170072014A1
公开(公告)日：2017-03-16
申请号：US15309195
申请日：2015-05-11
Inventor： Joab CHAPMAN , Efrat SHAVIT-STEIN
CPC classification number: A61K38/1796 , A61K38/00 , A61K38/57 , A61K45/06 , C07K5/0806 , C07K5/0819 , C07K5/101 , C07K5/1024 , C07K14/723
Abstract: The present invention is directed to a peptide conjugate comprising an alpha-amino protecting moiety, a peptide comprising the amino acid sequence at least 3 amino-acid long derived from the C′-terminus of PAR-1, or an active variant thereof and a protease-disabling moiety. The present invention is further directed to pharmaceutical compositions comprising the peptide conjugate and use thereof for treating diseases and disorder associated with excessive PAR-1 activity.
Abstract translation: 本发明涉及包含α-氨基保护部分的肽缀合物，包含源自PAR-1的C'末端的至少3个氨基酸长度的氨基酸序列的肽或其活性变体和 蛋白酶抑制部分。 本发明还涉及包含肽缀合物的药物组合物及其用于治疗与过度PAR-1活性相关的疾病和病症的用途。
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公开(公告)号：US20160303080A1
公开(公告)日：2016-10-20
申请号：US15101079
申请日：2014-10-29
Inventor： Merav LEIBA , Gabriela ROZIC
IPC: A61K31/404 , A61K45/06
CPC classification number: A61K31/404 , A61K45/06 , C07D405/04 , A61K2300/00
Abstract: A compound represented by Formula I is provided for use in the treatment of a hematological malignancy in a subject in need thereof. Also provided are compositions and kits which comprise the compound.
Abstract translation: 提供由式I表示的化合物用于治疗有需要的受试者的血液恶性肿瘤。 还提供了包含该化合物的组合物和试剂盒。
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Patent Agency Ranking
36.发明申请METHODS AND DEVICES FOR PROVIDING INFORMATION USEFUL IN THE DIAGNOSIS OF ABNORMALITIES OF THE GASTROINTESTINAL TRACT 审中-公开提供信息的方法和设备有助于诊断胃肠道疾病的不正常公开(公告)号：US20150173623A1
公开(公告)日：2015-06-25
申请号：US14639718
申请日：2015-03-05
Inventor： Genady KOSTENICH , Arie ORENSTEIN
CPC classification number: A61B5/0084 , A61B1/00036 , A61B1/00177 , A61B1/041 , A61B1/0615 , A61B1/0638 , A61B5/0075 , A61B5/073 , A61B5/42 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0216 , G01J3/0243 , G01J3/0272 , G01J3/0291 , G01J3/18 , G02B5/1861 , G02B23/2484 , G02B27/42 , G02B27/4244
Abstract: Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities.
Abstract translation: 公开的方法可用于提供有助于诊断胃肠道异常的信息以及可用于提供有用于诊断胃肠道异常的信息的可摄取装置。
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37.发明申请MEDICAL DEVICE, ASSEMBLY AND METHOD FOR CREATING A CHANNEL IN SOFT TISSUE 审中-公开医疗设备，组装和在软组织中创建通道的方法公开(公告)号：US20150127037A1
公开(公告)日：2015-05-07
申请号：US14408246
申请日：2013-06-13
Inventor： Vadim Shmukler , Yoseph Glovinsky
IPC: A61F9/007
CPC classification number: A61F9/00781 , A61B10/0275 , A61B10/0283 , A61B17/1659 , A61B17/320708 , A61B17/320758 , A61B17/320783 , A61B2017/0023 , A61B2017/320791
Abstract: The present disclosure provides a device, an assembly comprising the device and a method making use of same, the device comprising an elongated member extending between a first end and a second end, and a segment proximal to the second end extending along a longitudinal axis X, said segment comprises at least one depression axially extending along at least a portion of said segment and an external surface having a circumference C; and one or more blades with a cutting edge peripheral to C and the one or more blades extending along at least part of said segment; the first end comprising an engagement element for engagement with a grip unit comprising a rotor to cause rotation of said device about said axis upon actuation of the rotor and the second end comprising a tissue piercing tip. The device, assembly and method are useful in creating a channel in a biological soft tissue, such as a drainage channel in the sclero-corneal junction area of the eye. This may be useful in reducing intra-ocular pressure.
Abstract translation: 本公开提供了一种装置，包括该装置的组件和利用该装置的方法，所述装置包括在第一端和第二端之间延伸的细长构件，以及沿着纵向轴线X延伸的靠近第二端的区段 所述段包括至少一个沿所述段的至少一部分轴向延伸的凹陷和具有圆周C的外表面; 以及一个或多个刀片，其具有围绕C的切割边缘，并且所述一个或多个刀片沿着所述段的至少一部分延伸; 所述第一端包括用于与包括转子的把手接合的接合元件，所述转子在所述转子致动时围绕所述轴线旋转，并且所述第二端包括组织刺穿尖端。 装置，装配和方法可用于在生物软组织中形成通道，例如眼睛的硬化角膜连接区域中的排液通道。 这可能有助于减少眼内压。
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38.发明申请MICRORNA PATTERNS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MELANOMA 有权用于诊断，预防和治疗MELANOMA的MICRORNA模式公开(公告)号：US20140235488A1
公开(公告)日：2014-08-21
申请号：US14265337
申请日：2014-04-29
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY
Inventor： Gal Markel , Eyal Greenberg , Noam Shomron , Liat Edry , Jacob Schachter
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , A61K31/7105 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof.
Abstract translation: 本发明涉及用于诊断，分期，预后和治疗黑素瘤的方法，其基于评价有需要的患者中致癌或抑制性微小RNA（miR）分子的特异性模式的表达。
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39.发明申请PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME 有权用于预防细胞粘附的肽和组合物及其使用方法公开(公告)号：US20140155318A1
公开(公告)日：2014-06-05
申请号：US14016480
申请日：2013-09-03
Inventor： Amir ZLOTKIN
IPC: C07K14/435 , C07K7/08 , C07K7/06
CPC classification number: C07K14/435 , C02F1/441 , C02F1/50 , C02F2303/04 , C02F2303/20 , C07K7/06 , C07K7/08 , C07K14/43595
Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
Abstract translation: 包含分离的肽的组合物，其可以例如任选地包含选自FDYDWY（SEQ ID NO：2），SFSQNKSVHSFDYDWYNVSDQADLKN（SEQ ID NO：3）或CSFSQNKSVHSFDYDWYNVSDQADLKNC（SEQ ID NO：1）的序列，或任何环化的 版本及其使用方法，包括用于治疗或预防微生物生物膜的形成和细胞粘附于表面。
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公开(公告)号：US20140120554A1
公开(公告)日：2014-05-01
申请号：US14061277
申请日：2013-10-23
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Gal MARKEL , Rona ORTENBERG
IPC: G01N33/574
CPC classification number: C07K16/2803 , A61K35/17 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/14 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57473 , G01N33/57492 , G01N2333/70503
Abstract: A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.
Abstract translation: 公开了以ATCC登录号PTA-9974保藏的杂交瘤细胞。 还提供了抗体及其使用方法。
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