公开(公告)号：US20220381979A1

公开(公告)日：2022-12-01

申请号：US17753747

申请日：2020-09-11

Applicant: The University of Sheffield

Inventor： Alistair James Brash

IPC: G02B6/126 ,  G02B6/122

Abstract: A single photon source comprises a photon emitter (10), an excitation waveguide (30) arranged to direct excitation photons having a first polarisation direction into the photon emitter, and a collection waveguide (42) arranged to collect photons having a second polarisation direction from the photon emitter. The first polarisation direction is coupled to a first exciton state of the photon emitter and the second polarisation direction is non-parallel to the first polarisation direction and is coupled to a second exciton state of the photon emitter, and the first and second exciton states have substantially equal energies.

公开(公告)号：US20220265635A1

公开(公告)日：2022-08-25

申请号：US17286797

申请日：2019-10-18

Applicant: Aclipse One Inc. ,  The University of Sheffield

Inventor： Richard James Mead ,  Pamela Jean Shaw ,  Claude Ogoe ,  Ning Shan ,  Laura Ferraiuolo

IPC: A61K31/473 ,  A61P25/28

Abstract: The invention is directed to 6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol for the treatment of diseases mediated by protein misfolding, heat shock factor 1 pathways, or nuclear erythroid 2-related factor 2 pathways.

公开(公告)号：US20220162245A1

公开(公告)日：2022-05-26

申请号：US17600991

申请日：2020-04-02

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： James Anthony THOMAS ,  Kirsty Laura SMITTEN

IPC: C07F15/00

Abstract: A compound according to formula (I) or formula (Ia), and a composition comprising the compound for use as an antimicrobial: wherein, X1, X2, X3 and X4 are each independently selected from: N, O, S; Y1 and Y2 are each independently selected from: N, O, S, C(Ra); M1 and M2 are each a metal centre; R1, R2, R3, R4 and Ra are each independently selected from: hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, haloalkenyl, haloaryl, hydroxy, alkoxy, carboxylic acid, amino, amido, nitro or combination thereof; A1, A2, A3 and A4 are each bidentate ligands; and rings D1 and D2 are each independently comprise one or more heteroatoms selected from N, O, S, C(Ra); wherein said compound is for use as an antimicrobial.

公开(公告)号：US20220062286A1

公开(公告)日：2022-03-03

申请号：US17528034

申请日：2021-11-16

Applicant: The University of Sheffield

Inventor： Thomas Helleday

IPC: A61K31/517 ,  A61K31/5517 ,  A61K38/00 ,  C12N15/113 ,  C07D487/06 ,  A61K31/472

Abstract: The present invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.

公开(公告)号：US11067545B2

公开(公告)日：2021-07-20

申请号：US16064719

申请日：2016-12-21

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Robin Mills ,  Robert S. Dwyer-Joyce ,  Matthew Marshall

IPC: G01N29/04 ,  G01N29/34 ,  G01N29/48 ,  G01B17/02 ,  G01N29/12 ,  G01N29/44

Abstract: A continuous wave ultrasound analysis device for analysing a surface of a component includes an input to receive ultrasound data relating to continuous wave, swept frequency ultrasound propagated through the component; a processing section to derive a standing wave amplitude spectrum from the received ultrasound data, and determine a property of an unconstrained layer on the surface based on the standing wave amplitude spectrum; and an output to output the determined property of the layer. A method of continuous wave ultrasound for analysing a surface is also provided.

公开(公告)号：US20210161460A1

公开(公告)日：2021-06-03

申请号：US16065339

申请日：2016-12-21

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Brian BROWN ,  Dilichukwu ANUMBA

IPC: A61B5/00 ,  A61B5/0536

Abstract: Apparatus for determining the electrical conductivity of target cervical tissue using magnetic impedance spectroscopy comprising: an excitation coil for producing a magnetic field which is capable of inducing currents in the target cervical tissue; a gradiometer for detecting perturbations in said magnetic field caused by said induced currents, the gradiometer including screening means for minimising sensitivity to tissues other than the target tissue; processing means for determining an electrical conductivity of said target cervical tissue from said perturbations.

公开(公告)号：US10765779B2

公开(公告)日：2020-09-08

申请号：US15747410

申请日：2016-07-25

Applicant: The University of Sheffield

Inventor： Aileen Crawford-Corrie ,  David John Buttle ,  John William Haycock

IPC: A61L27/54 ,  A61F2/30 ,  A61L27/18 ,  A61L27/34 ,  A61L27/56 ,  A61L27/20 ,  A61K47/64 ,  A61K38/18

Abstract: The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.

公开(公告)号：US20200047375A1

公开(公告)日：2020-02-13

申请号：US16606649

申请日：2018-04-20

Applicant: McLaren Automotive Limited ,  The University of Sheffield

Inventor： Claudio Santoni ,  Elaine Arnold ,  Timothy Swait ,  Mark Laycock

IPC: B29C33/48

Abstract: A method for removing a hollow support element (17) from within a moulded part (15) to form a cavity (25) within the moulded part, the hollow support element being disposed within the moulded part and composed of material having a softening temperature, the method comprising: heating a liquid (20) to a temperature at least equal to the softening temperature of the material; injecting the heated liquid into an opening (24) in the moulded part to deform the material; and removing deformed material and liquid from the cavity.

公开(公告)号：US20200024639A1

公开(公告)日：2020-01-23

申请号：US16486408

申请日：2018-02-14

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Bazbek Davletov ,  Andrew Alexander Peden ,  Aleksander Mikael Rudolf Rust ,  Ciara Louise Doran

IPC: C12Q1/66 ,  C07K14/705 ,  C12Q1/37

Abstract: The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same.

公开(公告)号：US20190204159A1

公开(公告)日：2019-07-04

申请号：US16295143

申请日：2019-03-07

Applicant: The University of Sheffield

Inventor： Jonathan Raffe Willmott

IPC: G01J5/28 ,  G02B26/08 ,  G02B26/10 ,  G01J5/08 ,  H04N5/33

CPC classification number: G01J5/28 ,  G01J5/0809 ,  G01J2005/0077 ,  G02B26/0833 ,  G02B26/101 ,  H04N5/33

Abstract: A thermal imaging device is provided, comprising: a detector for receiving radiation and outputting a detector signal corresponding thereto; a steerable mirror device arranged in relation to the detector; wherein the steerable mirror device is steerable to scan an entrance pupil over a plurality of locations such that the detector outputs respective detector signals indicative of temperatures of respective portions of the object corresponding to the locations of the entrance pupil, and wherein the thermal imaging device is configured to provide a substantially constant etendue for all of the entrance pupil locations of the plurality of entrance pupil locations.