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公开(公告)号：US07047074B2
公开(公告)日：2006-05-16
申请号：US10077988
申请日：2002-02-19
Applicant: Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
Inventor： Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
IPC: A61N1/362
CPC classification number: G01R33/285 , A61N1/056 , A61N1/086 , A61N1/3718 , A61N1/375 , G01R33/288
Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.
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公开(公告)号：US20040161672A1
公开(公告)日：2004-08-19
申请号：US10782933
申请日：2004-02-23
Applicant: WILSON GREATBATCH LTD.
Inventor： Esther S. Takeuchi
IPC: H01M010/40 , H01M004/54 , H01M004/50 , H01M004/48
CPC classification number: H01M4/667 , H01M2/1653 , H01M2/1666 , H01M4/48 , H01M4/58 , H01M4/5835 , H01M4/66 , H01M4/661 , H01M4/663 , H01M4/669 , H01M6/16 , H01M6/164 , H01M2300/0037
Abstract: An autoclavable elctrochemical cell which may be used in an implantable medical device. The anode active material is lithium or other material from groups IA and IIA of the Periodic Table and having a melting point greater than about 150 degrees C. The cathode active material is silver vanadium oxide or other metal oxide or carbon monoflouride. The solvent for the electrolyte has a boiling point greater than about 100 degrees C. and a dielectric constant greater than about 5 so that the cell. may be dimensionally and chemically stable during repeated exposures of about one hour each to the autoclaving temperatures.
Abstract translation: 可用于可植入医疗装置的可高压消毒的电化学电池。 阳极活性材料是锂或来自元素周期表IA和IIA族的其它材料，其熔点大于约150℃。阴极活性材料是银钒氧化物或其它金属氧化物或单氟化碳。 用于电解质的溶剂具有大于约100℃的沸点和大于约5的介电常数，使得电池。 可以在反复暴露约1小时至高压灭菌温度期间在尺寸和化学上稳定。
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公开(公告)号：US5580761A
公开(公告)日：1996-12-03
申请号：US217210
申请日：1994-03-23
Applicant: Wilson Greatbatch , John C. Sanford
Inventor： Wilson Greatbatch , John C. Sanford
IPC: A61K48/00 , C07K14/15 , C07K14/155 , C12N15/113 , C12N15/867 , C12N15/11 , C07H21/02 , C07H21/04 , C12N5/10
CPC classification number: C12N15/1131 , C07K14/005 , C12N15/1132 , C12N15/86 , A61K48/00 , C12N2740/13022 , C12N2740/15022 , C12N2740/16043
Abstract: In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or corresponding, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting one or more steps in the retroviral infection process by interfering with retroviral replication, reverse transcription, translation, or assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using the nucleic acid constructs, or cells upon which resistance to infection has been conferred.
Abstract translation: 根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。 所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，其指导宿主细胞内的RNA，所述RNA是a）互补或相应的（取决于靶区域）的核酸序列与一个或多个 逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，通过干扰逆转录病毒复制，逆转录，翻译或组装成病毒颗粒来有效抑制逆转录病毒感染过程中的一个或多个步骤。 还公开了使用核酸构建体或其赋予抗感染性的细胞的治疗方法。
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公开(公告)号：US4291125A
公开(公告)日：1981-09-22
申请号：US112704
申请日：1980-01-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
CPC classification number: A01N59/16 , A61L2/035 , C02F1/4606 , Y10S435/80 , Y10S47/01
Abstract: A method and apparatus for killing plant and animal bacteria and plant viroids by electrically generated silver ions. The silver ions serve as germicidal agents in infection control and are generated by very slow electrical anodic corrosion of a silver wire located closely adjacent the infection site. In particular, a silver anode and a cathode of non-corroding metal are located in an electrolytic nutrient medium with the silver anode being within five millimeters of the infection site, and a direct voltage is applied to the anode and cathode in a manner passing a positive current in the microampere range into the silver anode causing it to corrode slightly and give off silver ions which produce a germicidal environment about the infection site.
Abstract translation: 一种用于通过电产生的银离子杀死植物和动物细菌并植入类病毒的方法和装置。 银离子在感染控制中用作杀菌剂，并且通过位于紧邻感染部位的银丝的非常缓慢的电阳极腐蚀产生。 特别地，非腐蚀金属的银阳极和阴极位于电解营养介质中，银阳极在感染部位的5毫米内，并且以通过一个方式的方式向阳极和阴极施加直流电压 在阳极范围内的正电流进入银阳极，导致其轻微腐蚀，并释放产生关于感染部位的杀菌环境的银离子。
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公开(公告)号：US4210708A
公开(公告)日：1980-07-01
申请号：US891636
申请日：1978-03-30
Applicant: Ralph T. Mead , Norbert W. Frenz, Jr. , Frank W. Rudolph , Wilson Greatbatch
Inventor： Ralph T. Mead , Norbert W. Frenz, Jr. , Frank W. Rudolph , Wilson Greatbatch
Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The lithium anode element is shaped in a manner increasing the area of the operative surface thereof and enhancing the bond to the anode conductor, and the anode operative surface is provided with a coating of an organic electron donor material. The anode conductor is enclosed within the combination of an insulator element within the casing, an isolator element between the insulator and the conductor, and a ferrule having one end associated with the insulator within the casing and the other end extending from the casing. After assembly, the cathode material is introduced in heated form by means of a filling element through an opening in the lid of the casing which subsequently is closed.
Abstract translation: 一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极 与壳体和锂元素。 阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。 锂阳极元件以增加其工作表面的面积并增强与阳极导体的结合的方式成形，并且阳极操作表面设置有有机电子给体材料的涂层。 阳极导体封装在壳体内的绝缘体元件的组合中，绝缘体和导体之间的隔离元件，以及一个套管，其一端与壳体内的绝缘体相关联，另一端从外壳延伸。 在组装之后，阴极材料通过填充元件以加热的形式通过壳体的盖中的开口引入，该开口随后被封闭。
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Patent Agency Ranking
公开(公告)号：US4132836A
公开(公告)日：1979-01-02
申请号：US853108
申请日：1977-11-21
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: An alkali metal-halogen cell comprising an alkali metal anode, preferably lithium, a solid alkali metal-halogen electrolyte and a cathode comprising a mixture of two halogens, for example iodine and bromine, the two halogens providing discharge of the cell at two different levels of cell output voltage. The two halogens are in different proportions by weight of the mixture thereby providing a two step output voltage-time characteristic. The cell advantageously can be employed in a battery for an artificial cardiac pacer.
Abstract translation: 包含碱金属卤素电池，其包含碱金属阳极，优选锂，固体碱金属 - 卤素电解质和包含两种卤素（例如碘和溴）的混合物的阴极，所述两种卤素提供电池在两个不同水平的放电 的电池输出电压。 两种卤素按混合物的重量不同，由此提供两步输出电压 - 时间特性。 该细胞有利地可用于人造心脏起搏器的电池。
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公开(公告)号：US4117212A
公开(公告)日：1978-09-26
申请号：US847769
申请日：1977-11-02
Applicant: Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz, Jr. , Wilson Greatbatch
Inventor： Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz, Jr. , Wilson Greatbatch
IPC: H01M6/18
CPC classification number: H01M6/182
Abstract: A lithium-iodine cell comprising a region of iodine-containing cathode material having at least two surface portions, a current collector element operatively contacting one of the surface portions and a lithium anode element operatively contacting the other cathode surface. The lithium anode element is embraced by a holder in a manner exposing a surface of the element to the cathode material and sealing the corresponding anode current collector element from exposure to the cathode material, the holder being of a material which does not exhibit electronic conduction when exposed to iodine. The anode and cathode current collectors have extending lead portions, and the cathode lead is insulated from the lithium anode element. A pair of cells are combined, being heat sealed together around the peripheries, with the corresponding cathode regions contacting opposite surfaces of a separator sheet to form a battery.
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公开(公告)号：US3969142A
公开(公告)日：1976-07-13
申请号：US557101
申请日：1975-03-10
Applicant: Wilson Greatbatch , Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz
Inventor： Wilson Greatbatch , Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz
Abstract: A lithium cell comprising a cathode including a region of iodine-containing material having a pair of operative surfaces and a cathode current collector in the region between the surfaces, a pair of lithium anode elements operatively contacting corresponding cathode surfaces and each having a current collector, and electrical conductors connected to the cathode and anode current collectors. Each anode element is fitted in a holder in a manner exposing a surface of each lithium element to the cathode material and sealing the anode current collector from exposure to the cathode material, the holders being of a material which does not exhibit electronic conduction when exposed to iodine. A pair of separator elements insulate the cathode conductor from the lithium anode elements. A pair of cells electrically connected in series and encapsulated in a single body provide a battery having an output of about 5 volts.
Abstract translation: 一种锂电池，包括在表面之间的区域中包括具有一对工作表面的含碘材料区域和阴极集电器的阴极，一对可操作地接触相应阴极表面并且各自具有集电器的锂阳极元件， 以及连接到阴极和阳极集电器的电导体。 每个阳极元件以将每个锂元素的表面暴露于阴极材料的方式装配在保持器中，并且将阳极集电器密封以暴露于阴极材料，所述保持器是当暴露于阴极材料时不显示电子传导的材料 碘。 一对分离器元件将阴极导体与锂阳极元件绝缘。 串联电连接并封装在单体中的一对电池提供具有约5伏的输出的电池。
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公开(公告)号：US3957533A
公开(公告)日：1976-05-18
申请号：US525051
申请日：1974-11-19
Applicant: Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph
Inventor： Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph
Abstract: A lithium-iodine cell comprising a cathode including a charge transfer complex of an organic donor component and iodine, an anode including a lithium element having a surface operatively contacting the charge transfer complex material, and a coating on the lithium surface of an organic electron donor material, preferably but not necessarily the organic donor component of the charge transfer complex. The organic electron donor material preferably comprises polyvinyl pyridine polymer and in particular two-vinyl pyridine polymer. A solution of two-vinyl pyridine polymer in benzene is brushed onto the anode lithium surface and then exposed to a desiccant. A number of coatings preferably are applied successively to provide a resulting or finished coating of increased thickness.
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公开(公告)号：US3937635A
公开(公告)日：1976-02-10
申请号：US539731
申请日：1975-01-09
Applicant: Ralph T. Mead , Wilson Greatbatch
Inventor： Ralph T. Mead , Wilson Greatbatch
Abstract: A lithium-iodine cell including a lithium anode, a lithium iodine electrolyte and a cathode comprising a source of iodine in the form of a substantially solid block or pellet of iodine and iodine-containing depolarizer material applied in the form of a relatively thin layer or coating to a lithium surface of the anode and to a surface of the iodine block. The depolarizer material serves to transport iodine ions from the source to the electrolyte, and the material is a charge transfer complex of an organic donor component and iodine such as 2-vinyl pyridine iodide.
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