公开(公告)号：US20080004698A1

公开(公告)日：2008-01-03

申请号：US11479223

申请日：2006-06-30

Applicant: Kamal K. Das ,  Xiaoxiao Zhang ,  Mutlu Karakelle ,  Xin Hong

Inventor： Kamal K. Das ,  Xiaoxiao Zhang ,  Mutlu Karakelle ,  Xin Hong

IPC: A61F2/16

CPC classification number: A61F2/142 ,  A61F2/145 ,  A61F2/16 ,  A61F9/007 ,  A61F2009/00848 ,  A61F2009/00851 ,  A61F2240/00 ,  A61F2240/001 ,  A61F2240/002

Abstract: In one aspect, the present invention provides a method of designing an ocular implant (e.g., an IOL), which comprises establishing corneal topography of a patient's eye, e.g., by performing one or more wavefront aberration measurements of the eye, prior to an ocular surgery. The method further includes ascertaining an astigmatic aberration of the cornea that is expected to be induced by the surgery and determining a toricity of a surface of an ocular implant, which is intended for implantation in the patient's eye, so as to enable the implant to compensate for the surgically-induced aberration.

Abstract translation: 一方面，本发明提供了一种设计眼部植入物（例如，IOL）的方法，其包括建立患者眼睛的角膜形貌，例如通过在眼睛之前执行眼睛的一个或多个波前像差测量 手术。 该方法还包括确定期望由手术引起的角膜的像散像差，并确定旨在植入患者眼睛中的眼部植入物的表面的复曲面，以使植入物能够补偿 用于手术诱发的像差。

公开(公告)号：US20070171362A1

公开(公告)日：2007-07-26

申请号：US11444112

申请日：2006-08-23

Applicant: Michael Simpson ,  Mutlu Karakelle ,  Steve Vannoy ,  Xiaoxiao Zhang ,  Xin Hong ,  Jihong Xie

Inventor： Michael Simpson ,  Mutlu Karakelle ,  Steve Vannoy ,  Xiaoxiao Zhang ,  Xin Hong ,  Jihong Xie

IPC: G02C7/02

CPC classification number: A61F2/1654 ,  A61F2/1618 ,  G02C7/042 ,  G02C7/044 ,  G02C2202/20

Abstract: In one aspect, the present invention provides a method of designing a diffractive ophthalmic lens (e.g., an intraocular lens (IOL)) that includes providing an optic having an anterior refractive surface and a posterior refractive surface, wherein the optic provides a far-focus power (e.g., in a range of about 18 to about 26 Diopters (D)). A truncated diffractive structure can be disposed on at least one of the surfaces for generating a near-focus add power (e.g., in a range of about 3 D to about 4 D). And the diffractive structure can be adjusted so as to obtain a desired distribution of optical energy between the near and far foci for a range of pupil sizes.

Abstract translation: 一方面，本发明提供了一种设计衍射眼用透镜（例如，眼内透镜（IOL））的方法，其包括提供具有前折射表面和后折射表面的光学元件，其中所述光学元件提供远焦点 功率（例如，在约18至约26屈光度（D）的范围内）。 截面的衍射结构可以设置在至少一个表面上，用于产生近焦点添加功率（例如，在约3D至约4D的范围内）。 并且可以调整衍射结构，以便在一定范围的瞳孔尺寸之间获得近焦点和远焦点之间期望的光能分布。

公开(公告)号：US20060244904A1

公开(公告)日：2006-11-02

申请号：US11397332

申请日：2006-04-04

Applicant: Xin Hong ,  Jihong Xie ,  Stephen Van Noy ,  Dan Stanley ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson

Inventor： Xin Hong ,  Jihong Xie ,  Stephen Van Noy ,  Dan Stanley ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson

IPC: G02C7/04

CPC classification number: A61F2/1613 ,  A61F2/1637 ,  G02C7/02

Abstract: In one aspect, the present invention provide an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior optical surface and a posterior optical surface, where the optic provides an optical power in a range of about 16 D to about 25 D as measured in a medium having an index of refraction substantially similar to that of the eye's aqueous humor (e.g., about 1.336). At least one of the optical surfaces is characterized by an aspherical base profile such that the optic exhibits a negative spherical aberration in a range of about −0.202 microns to about −0.190 microns across the power range.

Abstract translation: 一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有前光学表面和后光学表面的光学元件，其中所述光学元件提供在约16D至约25D的范围内的光焦度 如在具有基本上类似于眼睛房水的折射率的介质中测量的（例如，约1.336）。 至少一个光学表面的特征在于非球面基部轮廓，使得光学器件在功率范围内在约-0.202微米至约-0.190微米的范围内呈现负球面像差。

公开(公告)号：US08852273B2

公开(公告)日：2014-10-07

申请号：US13531170

申请日：2012-06-22

Applicant: Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

Inventor： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

IPC: A61F2/16

CPC classification number: A61F2/141 ,  A61B3/0025 ,  A61F2/1637 ,  A61F2240/001 ,  A61F2240/008

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract translation: 一方面，本发明提供一种设计眼内透镜（IOL）以解决患者眼睛中的至少一个眼睛参数的变化的方法。 该方法可以包括建立至少一个眼睛模型，其中眼睛参数可以在群体表现的范围上变化。 可以使用眼睛模型来评估多个IOL设计，以校正患者群体中的眼睛的视力。 然后可以选择提供最适合视觉性能的IOL设计，至少部分参数范围。

公开(公告)号：US08652205B2

公开(公告)日：2014-02-18

申请号：US12910446

申请日：2010-10-22

Applicant: Xin Hong ,  Mutlu Karakelle ,  Xioaxioa Zhang

Inventor： Xin Hong ,  Mutlu Karakelle ,  Xioaxioa Zhang

IPC: A61F2/16

CPC classification number: A61F2/1618 ,  A61F2/1654

Abstract: A diffractive multifocal design for ocular implant is provided. This ocular implant includes a diffractive multifocal intraocular lens (IOL) and a number of haptics. The diffractive multifocal IOL passes optical energy to distance, intermediate and near foci. The haptics mechanically couple to the diffractive multifocal IOL in order to position and secure the diffractive multifocal IOL within the eye. The diffractive multifocal IOL may include both a diffractive region and a refractive region, the diffractive multifocal IOL operable to phase shift optical energy such that constructive interference occurs within the diffractive region and the refractive region.

Abstract translation: 提供了用于眼部植入物的衍射多焦点设计。 这种眼部植入物包括衍射多焦点人工晶状体（IOL）和许多襻。 衍射多焦点IOL将光能传递到距离，中间和近距离焦点。 触觉件机械地耦合到衍射多焦点IOL以便将眼睛内的衍射多焦点IOL定位和固定。 衍射多焦点IOL可以包括衍射区域和折射区域，衍射多焦点IOL可操作以相移光能，使得在衍射区域和折射区域内发生相长的干涉。

公开(公告)号：US08562675B2

公开(公告)日：2013-10-22

申请号：US13562143

申请日：2012-07-30

Applicant: Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson ,  Myoung Choi ,  Yan Zhang

Inventor： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson ,  Myoung Choi ,  Yan Zhang

IPC: A61F2/16

CPC classification number: G02C7/044 ,  A61F2/1613 ,  G02C7/042

Abstract: In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).

Abstract translation: 一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。 至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。 辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差） 过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

公开(公告)号：US08262728B2

公开(公告)日：2012-09-11

申请号：US12776807

申请日：2010-05-10

Applicant: Xiaoxiao Zhang ,  Richard J. Mackool ,  Xin Hong ,  Michael A. Southard

Inventor： Xiaoxiao Zhang ,  Richard J. Mackool ,  Xin Hong ,  Michael A. Southard

IPC: A61F2/16

CPC classification number: A61F2/1654 ,  A61F2/1618

Abstract: An intraocular lens device that includes an intraocular lens optics that provides at least two powers of magnification one being near vision power and the other being distance vision power. The lens optics has surface modulations that are responsible for providing the near vision power. The zone structure provides an add power of over 6 diopters. The add power indicative of an extent that the near vision focusing power is greater than the distance vision focusing power.

Abstract translation: 一种眼内透镜装置，其包括眼内透镜光学元件，其提供至少两个放大倍率的功率，其是近视力，另一个是距离视力。 透镜光学器件具有负责提供近视力的表面调制。 区域结构提供超过6屈光度的附加功率。 附加功率表示近视聚焦功率大于距离视觉聚焦功率的程度。

公开(公告)号：US08211172B2

公开(公告)日：2012-07-03

申请号：US12971125

申请日：2010-12-17

Applicant: Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

Inventor： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

IPC: A61F2/16

CPC classification number: A61F2/141 ,  A61B3/0025 ,  A61F2/1637 ,  A61F2240/001 ,  A61F2240/008

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract translation: 一方面，本发明提供一种设计眼内透镜（IOL）以解决患者眼睛中的至少一个眼睛参数的变化的方法。 该方法可以包括建立至少一个眼睛模型，其中眼睛参数可以在群体表现的范围上变化。 可以使用眼睛模型来评估多个IOL设计，以校正患者群体中的眼睛的视力。 然后可以选择提供最适合视觉性能的IOL设计，至少部分参数范围。

公开(公告)号：US20110085133A1

公开(公告)日：2011-04-14

申请号：US12971125

申请日：2010-12-17

Applicant: Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

Inventor： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

IPC: A61F2/16 ,  G02C7/02

CPC classification number: A61F2/141 ,  A61B3/0025 ,  A61F2/1637 ,  A61F2240/001 ,  A61F2240/008

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract translation: 一方面，本发明提供一种设计眼内透镜（IOL）以解决患者眼睛中的至少一个眼睛参数的变化的方法。 该方法可以包括建立至少一个眼睛模型，其中眼睛参数可以在群体表现的范围上变化。 可以使用眼睛模型来评估多个IOL设计，以校正患者群体中的眼睛的视力。 然后可以选择提供最适合视觉性能的IOL设计，至少部分参数范围。

公开(公告)号：US07780728B2

公开(公告)日：2010-08-24

申请号：US11435905

申请日：2006-05-17

Applicant: Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

Inventor： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

IPC: A61F2/16

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.