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    Cardiac activation sequence monitoring and tracking
    32.
    发明授权
    Cardiac activation sequence monitoring and tracking 有权
    心脏激活序列监测和跟踪

    公开(公告)号：US08380293B2

    公开(公告)日：2013-02-19

    申请号：US13027612

    申请日：2011-02-15

    申请人： Yi Zhang ,  Scott Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos A Ricci

    发明人： Yi Zhang ,  Scott Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos A Ricci

    IPC分类号： A61B5/0428 ,  A61B5/0452

    CPC分类号： A61B5/04011 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

    IMPLANTABLE MEDICAL DEVICE SENSING AND SELECTING WIRELESS ECG AND INTRACARDIAC ELECTROGRAM
    33.
    发明申请
    IMPLANTABLE MEDICAL DEVICE SENSING AND SELECTING WIRELESS ECG AND INTRACARDIAC ELECTROGRAM 审中-公开
    可植入医疗设备感应和选择无线心电图和内皮细胞电泳

    公开(公告)号：US20120289847A1

    公开(公告)日：2012-11-15

    申请号：US13535104

    申请日：2012-06-27

    申请人： Yi Zhang ,  Aaron McCabe ,  David J. Yonce ,  Julie Thompson

    发明人： Yi Zhang ,  Aaron McCabe ,  David J. Yonce ,  Julie Thompson

    IPC分类号： A61B5/0464 ,  A61B5/0452

    CPC分类号： A61N1/3956 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/686 ,  A61N1/3622 ,  A61N1/3706 ,  A61N1/3712 ,  A61N1/3756 ,  A61N1/3925 ,  A61N2001/083

    摘要： A CRM system enhances intracardiac electrogram-based arrhythmia detection using a wireless electrocardiogram (ECG), which is a signal sensed with implantable electrodes and approximating a surface ECG. In one embodiment, an intracardiac electrogram allows for detection of an arrhythmia, and the wireless ECG allows for classification of the detected arrhythmia by locating its origin. In another embodiment, the wireless ECG is sensed as a substitute signal for the intracardiac electrogram when the sensing of the intracardiac electrogram becomes unreliable. In another embodiment, a cardiac signal needed for a particular purpose is selected from one or more intracardiac electrograms and one or more wireless ECGs based on a desirable signal quality. In another embodiment, intracardiac electrogram-based arrhythmia detection and wireless ECG-based arrhythmia detection confirm with each other before indicating a detection of arrhythmia of a certain type.

    摘要翻译： CRM系统使用无线心电图（ECG）来增强基于心脏电图的心律失常检测，无线心电图（ECG）是用可植入电极感测并近似表面ECG的信号。 在一个实施例中，心内电描记图允许检测心律失常，并且无线ECG允许通过定位其起点来分类检测到的心律失常。 在另一个实施例中，当心脏电图的感测变得不可靠时，无线ECG被感测为心内电描记图的替代信号。 在另一个实施例中，基于期望的信号质量，从一个或多个心内电描记图和一个或多个无线ECG选择特定目的所需的心脏信号。 在另一个实施例中，基于心脏电图的心律失常检测和基于无线ECG的心律失常检测在指示某种类型的心律失常的检测之前相互确认。

    Automatic capture verification using electrocardiograms sensed from multiple implanted electrodes
    35.
    发明授权
    Automatic capture verification using electrocardiograms sensed from multiple implanted electrodes 失效
    使用从多个植入电极感测的心电图进行自动捕获验证

    公开(公告)号：US08116871B2

    公开(公告)日：2012-02-14

    申请号：US12409348

    申请日：2009-03-23

    申请人： Yi Zhang ,  Jiang Ding ,  Aaron McCabe ,  Scott A. Meyer

    发明人： Yi Zhang ,  Jiang Ding ,  Aaron McCabe ,  Scott A. Meyer

    IPC分类号： A61N1/08 ,  A61N1/37 ,  A61B5/0452

    CPC分类号： A61N1/3712 ,  A61N1/365

    摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

    摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离被用于使用心脏激活序列信息的自动捕获验证。 装置和方法使用可植入电极感测复合心脏信号。 使用复合信号进行源分离。 产生与基于源分离的一个或多个心脏激活序列的全部或一部分相关联的一个或多个信号载体。 使用与心脏信号矢量相关联的特征和与矢量相关联的信号来分类对起搏脉冲的心脏反应。 进一步的实施方案可以包括将心脏反应分类为捕获或非捕获，融合或内在心脏活动。 特征可以包括心脏信号矢量的角度或角度变化，例如一个或多个心脏信号矢量的预定角度范围。

    Automatic Orientation Determination for ECG Measurements Using Multiple Electrodes
    37.
    发明申请
    Automatic Orientation Determination for ECG Measurements Using Multiple Electrodes 有权
    使用多个电极进行心电图测量的自动测向

    公开(公告)号：US20100198283A1

    公开(公告)日：2010-08-05

    申请号：US12694833

    申请日：2010-01-27

    申请人： Yi Zhang ,  Marina Brockway ,  Carlos Alberto Ricci ,  Ron Heil ,  Douglas R. Daum ,  Robert J. Sweeney ,  Aaron McCabe

    发明人： Yi Zhang ,  Marina Brockway ,  Carlos Alberto Ricci ,  Ron Heil ,  Douglas R. Daum ,  Robert J. Sweeney ,  Aaron McCabe

    IPC分类号： A61N1/362 ,  A61N1/39 ,  A61B5/04

    CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/7207 ,  A61B5/7217 ,  A61N1/3756 ,  G06K9/624

    摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。 信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。 信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。 如果需要或必要，可以更新所选择的向量。 信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。 分离可以包括主成分分析和/或独立成分分析。 可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

    NEUROSTIMULATION SYSTEMS AND METHODS FOR CARDIAC CONDITIONS
    39.
    发明申请
    NEUROSTIMULATION SYSTEMS AND METHODS FOR CARDIAC CONDITIONS 审中-公开
    心脏条件的神经系统和方法

    公开(公告)号：US20080015659A1

    公开(公告)日：2008-01-17

    申请号：US11860936

    申请日：2007-09-25

    申请人： Yi Zhang ,  Anthony Caparso ,  Imad Libbus ,  Aaron McCabe ,  Scott Meyer ,  Marina Brockway

    发明人： Yi Zhang ,  Anthony Caparso ,  Imad Libbus ,  Aaron McCabe ,  Scott Meyer ,  Marina Brockway

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36114 ,  A61B5/04012 ,  A61B5/4519 ,  A61N1/3622 ,  A61N1/3627

    摘要： Various embodiments provide an implantable medical device comprising a detector, a neural stimulator, and a controller. The detector is configured to detect a pathological condition indicated for an acute neural stimulation therapy. The neural stimulator is capable of delivering a chronic neural stimulation therapy and the acute neural stimulation therapy. The controller is configured to control the neural stimulator to provide the chronic neural stimulation therapy, receive an indicator from the detector that the pathological condition is detected, and control the neural stimulator to integrate the acute neural stimulation therapy with the chronic neural stimulation therapy in response to the indicator.

    摘要翻译： 各种实施例提供了包括检测器，神经刺激器和控制器的可植入医疗装置。 检测器被配置为检测针对急性神经刺激治疗指示的病理状况。 神经刺激器能够递送慢性神经刺激治疗和急性神经刺激治疗。 控制器被配置为控制神经刺激器以提供慢性神经刺激治疗，从检测器接收到检测到病理状况的指示器，并且控制神经刺激器将急性神经刺激治疗与慢性神经刺激治疗结合起来 到指标。