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公开(公告)号：US10213949B2
公开(公告)日：2019-02-26
申请号：US14852135
申请日：2015-09-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
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公开(公告)号：US20180318116A1
公开(公告)日：2018-11-08
申请号：US16034285
申请日：2018-07-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Erik David Eli , Syed Hossainy , Mikael Trollsas , Michael H. Ngo , Stephen Pacetti , Michael Green , John Papp
CPC classification number: A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/828 , A61F2002/91575 , A61F2002/91591 , A61F2210/0004 , A61F2220/0075 , A61F2220/0091
Abstract: A scaffold is formed by several segments joined or connected to each other by only at least one coupling. The coupling decouples the segments in the axial direction over a finite distance of axial displacement. The scaffold when implanted in a peripheral vessel reduces loading on rings of a segment due to the decoupling of the segments in the axial direction over the finite distance.
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公开(公告)号：US20180280165A1
公开(公告)日：2018-10-04
申请号：US16000804
申请日：2018-06-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Joan Bei , Karen Wang , Annie Liu
Abstract: A scaffold includes a radiopaque marker connected to a strut. The marker is retained within the strut by one or more of a mechanical interference fit, a polymer coating or melt, and/or by friction. The marker can take the form of a bead, rivet or snap-in marker, or a tube deformed when attached to the strut. The strut is made from a tube. The strut has a thickness of about 100 microns.
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公开(公告)号：US09918857B2
公开(公告)日：2018-03-20
申请号：US14615314
申请日：2015-02-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Jamey Jacobs , Stephen Pacetti
CPC classification number: A61F2/915 , A61F2/958 , A61F2002/91575 , A61F2210/0004 , A61F2230/0004 , A61F2240/001 , A61F2250/0036 , A61L31/06 , A61L31/14 , B29C59/085 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08L67/04
Abstract: A scaffold strut is shaped to improve hemocompatibility. After laser cutting, the scaffold is placed on a work piece and its struts are shaped by flame polishing or brushing. The abluminal surfaces and luminal surfaces can have corners rounded. The strut can have a sloped surface on its luminal side without reducing strut thickness needed for strength.
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公开(公告)号：US09724452B2
公开(公告)日：2017-08-08
申请号：US15161084
申请日：2016-05-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Ni Ding , Stephen Pacetti , Marika Kamberi , Cameron Kerrigan
IPC: A61L31/10 , A61L31/16 , A61L31/14 , A61K47/48 , A61K31/436
CPC classification number: A61L31/16 , A61K31/436 , A61K47/593 , A61K47/6957 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2420/02 , C08L67/04
Abstract: Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating.
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Patent Agency Ranking
公开(公告)号：US09603943B2
公开(公告)日：2017-03-28
申请号：US14750732
申请日：2015-06-25
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K31/74 , A61K47/48 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K47/34 , C08L77/12 , A61K31/727
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
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37.发明授权公开(公告)号：US09539125B2
公开(公告)日：2017-01-10
申请号：US14858336
申请日：2015-09-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
CPC classification number: A61F2/90 , A61F2/89 , A61F2/915 , A61F2002/91566 , A61F2230/0069 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , A61K49/04 , A61L31/022 , A61L31/16 , A61L31/18
Abstract: An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.
Abstract translation: 可植入假体可以包括具有内腔，管腔内的不透射线颗粒的支柱和聚合物粘合剂。 聚合物粘合剂将不透射线的颗粒保留在管腔内。 支柱可以具有侧孔，治疗剂通过该侧孔，不透射线的颗粒不能通过。 聚合物粘合剂可以不存在或任选。 不透射线的颗粒可以具有防止它们通过侧孔从管腔逸出的尺寸。 放置在内腔内的不透射线颗粒可以改善植入术期间假体的可视化。
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38.发明申请SCAFFOLD HAVING A SHAPED STRUT AND METHODS FOR SHAPING SCAFFOLD STRUTS 有权具有形状条纹的SCAFFOLD和形成SCAFFOLD STRUTS的方法公开(公告)号：US20160200035A1
公开(公告)日：2016-07-14
申请号：US14615314
申请日：2015-02-05
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Jamey Jacobs , Stephen Pacetti
CPC classification number: A61F2/915 , A61F2/958 , A61F2002/91575 , A61F2210/0004 , A61F2230/0004 , A61F2240/001 , A61F2250/0036 , A61L31/06 , A61L31/14 , B29C59/085 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08L67/04
Abstract: A scaffold strut is shaped to improve hemocompatibility. After laser cutting, the scaffold is placed on a work piece and its struts are shaped by flame polishing or brushing. The abluminal surfaces and luminal surfaces can have corners rounded. The strut can have a sloped surface on its luminal side without reducing strut thickness needed for strength.
Abstract translation: 支架支架的形状可改善血液相容性。 激光切割后，将支架放置在工件上，其支柱通过火焰抛光或刷涂成型。 腹腔表面和腔表面可以具有圆角。 支柱可以在其腔侧具有倾斜表面，而不会减小强度所需的支柱厚度。
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公开(公告)号：US20160030211A1
公开(公告)日：2016-02-04
申请号：US14858355
申请日：2015-09-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti
IPC: A61F2/89
CPC classification number: A61F2/90 , A61F2/89 , A61F2/915 , A61F2002/91566 , A61F2230/0069 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , A61K49/04 , A61L31/022 , A61L31/16 , A61L31/18
Abstract: An implantable prosthesis can comprise a strut having a lumen, radiopaque particles within the lumen, and a polymer binder. The polymer binder retains the radiopaque particles within the lumen. The strut may have side holes through which a therapeutic agent may pass and through which the radiopaque particles are incapable of passing. The polymer binder may be absent or optional. The radiopaque particles can have sizes that prevent them from escaping out of the lumen through the side holes. The radiopaque particles placed within the lumen can improve visualization of the prosthesis during an implantation procedure.
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40.发明申请CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开控制用于熔融加工的可生物降解聚合物的水分和塑化公开(公告)号：US20150375437A1
公开(公告)日：2015-12-31
申请号：US14852135
申请日：2015-09-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
IPC: B29C47/00
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/0066 , B29C47/0869 , B29C47/0893 , B29C47/0894 , B29C47/1018 , B29C47/1027 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92333 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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