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公开(公告)号：US11324614B2
公开(公告)日：2022-05-10
申请号：US16172599
申请日：2018-10-26
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC: A61F2/915 , A61F2/82 , A61F2/958 , A61F2/89 , B21D39/04 , A61F2/91 , A61L31/06 , A61L31/14 , A61F2/95 , A61L27/00 , A61F2/86 , A61F2/844 , B29C35/08 , B29K67/00 , B29L23/00 , B29L31/00
Abstract: A medical device includes a polymer stent (or scaffold) crimped to a catheter balloon. The stent, after being expanded from a crimped state by the balloon, provides a crush recovery of about 90% of its expanded diameter after being pinched or crushed by an amount equal to about 50% of the expanded diameter. The stent has a pattern including a W-shaped or W-V shaped closed cell and links connecting the closed cells.
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公开(公告)号：US20190060097A1
公开(公告)日：2019-02-28
申请号：US16172599
申请日：2018-10-26
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC: A61F2/958 , A61L31/06 , A61L31/14 , B21D39/04 , B29C35/08 , A61F2/915 , A61F2/844 , A61F2/86 , A61L27/00 , A61F2/91 , A61F2/82 , A61F2/95 , A61F2/89 , B29K67/00 , B29L31/00 , B29L23/00
Abstract: A medical device includes a polymer stent (or scaffold) crimped to a catheter balloon. The stent, after being expanded from a crimped state by the balloon, provides a crush recovery of about 90% of its expanded diameter after being pinched or crushed by an amount equal to about 50% of the expanded diameter. The stent has a pattern including a W-shaped or W-V shaped closed cell and links connecting the closed cells.
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公开(公告)号：US10166129B2
公开(公告)日：2019-01-01
申请号：US14581993
申请日：2014-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Richard Rapoza , Yunbing Wang , James P. Oberhauser , Syed Hossainy
Abstract: Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
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公开(公告)号：US20180318116A1
公开(公告)日：2018-11-08
申请号：US16034285
申请日：2018-07-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Erik David Eli , Syed Hossainy , Mikael Trollsas , Michael H. Ngo , Stephen Pacetti , Michael Green , John Papp
CPC classification number: A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/828 , A61F2002/91575 , A61F2002/91591 , A61F2210/0004 , A61F2220/0075 , A61F2220/0091
Abstract: A scaffold is formed by several segments joined or connected to each other by only at least one coupling. The coupling decouples the segments in the axial direction over a finite distance of axial displacement. The scaffold when implanted in a peripheral vessel reduces loading on rings of a segment due to the decoupling of the segments in the axial direction over the finite distance.
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公开(公告)号：US09956097B2
公开(公告)日：2018-05-01
申请号：US13842547
申请日：2013-03-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Hossainy , Chad J. Abunassar , Michael Huy Ngo , Erik David Eli , Santosh V. Prabhu , Mikael Trollsas , Richard Rapoza
CPC classification number: A61F2/915 , A61F2/958 , A61F2002/91575 , A61F2210/0004 , A61F2230/0054 , A61F2240/00 , A61F2240/008 , A61F2250/0071 , A61L31/06 , B29C55/24 , B29C55/26 , B29C69/001 , B29L2031/753 , Y10T29/49 , Y10T29/49927 , C08L67/04
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings.
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Patent Agency Ranking
公开(公告)号：US09763818B2
公开(公告)日：2017-09-19
申请号：US14085716
申请日：2013-11-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC: A61F2/958 , A61F2/91 , A61L27/00 , A61L31/06 , A61F2/86 , A61F2/844 , B29C35/08 , A61L31/14 , A61F2/89 , A61F2/82 , A61F2/915 , A61F2/95 , B29K67/00 , B29L23/00 , B29L31/00
CPC classification number: A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
Abstract: A method of crimping a stent is disclosed. The stent includes a minimum crimped diameter such that in the minimum crimped diameter, a pair of stent rings, between which marker support structures reside, do not make contact with the marker support structures. The crimped profile of the stent of the present invention can be as small as the crimped profile of a same stent but without the maker support structures.
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公开(公告)号：US09603943B2
公开(公告)日：2017-03-28
申请号：US14750732
申请日：2015-06-25
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K31/74 , A61K47/48 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K47/34 , C08L77/12 , A61K31/727
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
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公开(公告)号：US20170042816A1
公开(公告)日：2017-02-16
申请号：US15242403
申请日：2016-08-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , John Stankus , James Su , Syed Hossainy , Joshua Takeshi Smith , Shadid Askar
CPC classification number: A61K9/146 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K38/215 , A61K47/10 , A61K2039/505 , C07K16/241 , C07K16/40 , C07K2317/21
Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.
Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。
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公开(公告)号：US09517150B2
公开(公告)日：2016-12-13
申请号：US13842432
申请日：2013-03-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Hossainy , Mikael Trollsas , Michael Huy Ngo , Erik David Eli
CPC classification number: A61F2/915 , A61F2/958 , A61F2002/91575 , A61F2210/0004 , A61F2230/0054 , A61F2240/00 , A61F2240/008 , A61F2250/0071 , A61L31/06 , B29C55/24 , B29C55/26 , B29C69/001 , B29L2031/753 , Y10T29/49 , Y10T29/49927 , C08L67/04
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架具有当植入在外周血管内时产生较低的晚期管腔损失并且也表现出高的轴向疲劳寿命的结构。 在优选实施例中，支架形成通过连杆互连的环形结构，其中环具有12个冠部，并且至多两个连接相邻环件的连杆。
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40.发明授权公开(公告)号：US09510976B2
公开(公告)日：2016-12-06
申请号：US14265343
申请日：2014-04-29
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Syed Hossainy , Paul Consigny , Dariush Davalian , James Su , Michael Ngo , Adrain Gale , Jesus Magana , Mikael Trollsas , Evan Norton , Benjamyn Serna
CPC classification number: A61F2/958 , A61B1/06 , A61F2/915 , A61F11/002 , A61F2002/91575 , A61F2002/91583 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0046 , A61F2250/0048 , A61F2250/005 , A61F2250/0082 , A61M25/10 , A61M29/02 , A61M2025/105 , A61M2025/1059 , A61M2210/0675
Abstract: A polymeric stent can be implanted for treatment of the Eustachian tube. The stent can be designed to have length-dependent radial strength to allow it to stay within the Eustachian tube and to allow normal closing and opening of the Eustachian tube. A balloon can be used to implant the stent, and the balloon can be coated with a therapeutic agent. A coated balloon can also be used to transfer therapeutic agents to the sinus cavity during a balloon sinus dilation procedure.
Abstract translation: 可以植入聚合物支架以治疗咽鼓管。 支架可以设计成具有长度依赖的径向强度，以允许其保持在咽鼓管内并允许正常的关闭和打开咽鼓管。 可以使用气囊来植入支架，并且可以用治疗剂涂覆气囊。 在气球窦扩张过程中，涂覆的气囊也可以用于将治疗剂转移到窦腔。
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