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    DEFLECTOR FOR INCREASED WALL SHEAR STRESS ADJACENT AN ARTERIOVENOUS FISTULA
    4.
    发明申请
    DEFLECTOR FOR INCREASED WALL SHEAR STRESS ADJACENT AN ARTERIOVENOUS FISTULA 审中-公开
    增加墙壁剪应力的偏角器附近有异物

    公开(公告)号：US20150157475A1

    公开(公告)日：2015-06-11

    申请号：US14099206

    申请日：2013-12-06

    申请人： Abbott Cardiovascular Systems Inc.

    发明人： Paul Consigny ,  Jesus Managa

    IPC分类号： A61F2/82 ,  A61F2/95

    CPC分类号： A61F2/82 ,  A61F2/94 ,  A61F2/95 ,  A61F2002/068 ,  A61F2002/8486 ,  A61M1/3653 ,  A61M1/3655

    摘要： A medical device includes an elongate body having a distal and proximal end, a pair of anchors at the distal end and spacers extending along its length. The body is delivered to an AV fistula using a catheter connected to the proximal end by a tether. The body when deployed at the fistula is suspended within the flow stream and spaced from walls of a blood vessel. The body deflects blood flow to cause an increase in vascular wall shear stress, which has been found to induce a positive vascular remodeling.

    摘要翻译： 医疗装置包括具有远端和近端的细长主体，在远端处的一对锚固件和沿其长度延伸的间隔件。 使用连接到近端的导管将身体输送到AV瘘管。 在瘘管部署时的身体悬浮在流动流中并与血管的壁隔开。 身体偏转血流，导致血管壁剪切应力增加，已被发现导致血管重塑。

    METHODS AND COMPOSITIONS FOR TREATMENT OF LESIONED SITES OF BODY VESSELS
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATMENT OF LESIONED SITES OF BODY VESSELS 审中-公开
    用于处理身体血管的位点的方法和组合物

    公开(公告)号：US20140154300A1

    公开(公告)日：2014-06-05

    申请号：US14175933

    申请日：2014-02-07

    申请人： Abbott Cardiovascular Systems Inc.

    发明人： Florian Niklas Ludwig ,  Stephen Pacetti ,  Paul Consigny

    IPC分类号： A61K33/00 ,  A61K31/198 ,  A61K38/44 ,  A61K9/00 ,  A61K38/00

    CPC分类号： A61K33/00 ,  A61K9/00 ,  A61K31/198 ,  A61K38/005 ,  A61K38/44 ,  A61L27/38 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/40

    摘要： Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.

    摘要翻译： 本文公开了在身体损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其它合适的装置之类的递送系统实现递送。

    SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE
    8.
    发明申请
    SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE 审中-公开
    医疗器械的表面改性，以增强内皮粘连和覆盖

    公开(公告)号：US20130103138A1

    公开(公告)日：2013-04-25

    申请号：US13655762

    申请日：2012-10-19

    申请人： Abbott Cardiovascular Systems Inc.

    发明人： Syed Hossainy ,  Mikael Trollsas ,  Kristen O'Halloran Cardinal ,  Marcus Foley ,  Paul Consigny

    IPC分类号： A61F2/82 ,  B05D5/00

    CPC分类号： A61L31/043 ,  A61F2/0077 ,  A61F2/07 ,  A61F2/91 ,  A61L31/10 ,  A61L2400/18

    摘要： Acceleration of the endothelialization process on implantable medical devices having at least one blood-contacting surface is achieved by a microscale pattern of sub-sections of EC-inductive coatings or EC-conductive coatings and nano/macro textured surfaces. The EC-inductive coating and EC-conductive coating can be applied either on the entire surface of the blood-contacting surface or selective placed on the blood-contacting surface, for example, in particular patterns. In this regard, the EC-conductive and EC-inductive coatings can be selectively placed relative to the textured surface to achieve a desired pattern of texture surface to coatings.

    摘要翻译： 具有至少一个血液接触表面的可植入医疗装置上的内皮化过程的加速通过EC感应涂层或EC-导电涂层和纳米/宏纹理表面的细分图形来实现。 EC感应涂层和EC-导电涂层可以施用在接触血液的表面的整个表面上，或者被选择性地施加在接触血液的表面上，例如特别是图案。 在这方面，EC导电和EC感应涂层可以相对于纹理表面选择性地放置，以获得所需的纹理表面与涂层的图案。