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公开(公告)号：US4508226A
公开(公告)日：1985-04-02
申请号：US514947
申请日：1983-07-18
CPC分类号： B65D5/4279 , B65D5/0227 , Y10S206/807
摘要： This relates to a sealed carton formed of paperboard which is provided with tamper indicating features. First of all, the ends of the carton are formed of a combination of partial and full closure flaps and the full closure flaps are provided with weakened areas so that if the closure flaps are attempted to be separated, there will be a rupture of either one or both of the full closure flaps so as to indicate attempted tampering. On the other hand, if an attempt is made to open the carton along the joint between the body panel and the connecting panel, the connecting panel carries at opposite ends thereof closure flaps which are incorporated in the ends of the carton and there is a weakening line arrangement such that rupture of the closure flaps carried by the connecting panel from the connecting panel will occur to indicate an attempt to tamper.
摘要翻译： 这涉及由纸板形成的密封纸箱，其设置有篡改指示特征。 首先，纸箱的端部由部分的和完全的闭合襟翼的组合形成，并且完全的闭合襟翼设置有削弱的区域，使得如果试图分离闭合襟翼，则会有任何一个 或两个完整的关闭襟翼，以便指示企图篡改。 另一方面，如果试图沿着主体面板和连接面板之间的接合处打开纸箱，则连接面板在其相对端处承载有闭合襟翼，该襟翼包括在纸箱的端部中，并且存在弱化 线路布置，使得连接面板从连接面板承载的闭合翼片的破裂将发生，以指示试图窜改。
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公开(公告)号：US4317996A
公开(公告)日：1982-03-02
申请号：US111872
申请日：1980-01-14
申请人： Robert E. Davis
发明人： Robert E. Davis
摘要： Methods for detection of the presence or absence of water leaks in building roofs and for tracing any leaks to the zone or area thereof in the roof by applying on all or part of the roof fluorescent dye-containing water, shining a fluorescence-inducing light, e.g., actinic or U/V light, onto the underside of the roof, its support structures, roof-penetrating structures and/or surfaces of walls beneath the roof, tracing the path or paths of fluorescence (if present) along the underside of said roof, and/or roof-penetrating structures, and/or roof support structures, and/or the building wall(s) to or near the point of origin of the area or zone of water leakage through said roof, and optionally applying the fluorescent dye-containing water onto the roof in the form of a spray in a fast-moving air stream or as a water jet or jet-spray to simulate wind-driven rain.
摘要翻译： 用于检测建筑物屋顶中是否存在漏水的方法，以及通过施加在全部或部分屋顶含荧光染料的水上，照射荧光诱导光，以及用于追踪在屋顶的区域或区域中的任何泄漏， 例如，光化或U / V光，到屋顶的下侧，其支撑结构，屋顶穿透结构和/或屋顶下方的墙壁表面，沿着所述第一主体的下侧跟踪荧光（如果存在）的路径或路径 屋顶和/或屋顶穿透结构，和/或屋顶支撑结构，和/或建筑物壁到通过所述屋顶泄漏的区域或区域的原点或其附近，并且可选地施加荧光 含有染料的水以喷雾形式在快速移动的空气流中或作为水射流或喷射喷雾以模拟风力下雨到屋顶上。
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公开(公告)号：US4177134A
公开(公告)日：1979-12-04
申请号：US887867
申请日：1978-03-20
摘要： An improved coal deashing process wherein a feed mixture comprising soluble coal products, insoluble coal products, and deashing solvent at a first temperature level is separated in a first separation zone into a first light fraction and a first heavy fraction comprising the insoluble coal products and some of the deashing solvent through admixing predetermined quantities of an additive with the feed mixture prior to separation to provide an improved yield of recoverable soluble coal products. Alternatively, the additive is admixed with the first light fraction prior to subsequent separations to provide an improved yield of recoverable soluble coal products.
摘要翻译： 一种改进的脱煤方法，其中将包含可溶性煤产品，不溶性煤产品和在第一温度水平下的脱溶剂的进料混合物在第一分离区域分离成第一轻馏分和包含不溶性煤产品和一些 的脱溶剂溶剂，通过在分离前将预定量的添加剂与进料混合物混合，以提供可回收的可溶性煤产品的改进产率。 或者，在随后的分离之前，将添加剂与第一轻馏分混合，以提供可回收的可溶性煤产品的改进产率。
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公开(公告)号：US3950873A
公开(公告)日：1976-04-20
申请号：US570487
申请日：1975-04-22
申请人： John J. Stehle , Robert E. Davis
发明人： John J. Stehle , Robert E. Davis
摘要： Hollow molded plastic support member for use in forming a variety of traffic warning devices has an inverted Y-shape which forms a pair of spaced angled legs and a vertical post portion. The post portion includes a pair of vertically elongated, spaced apertures defined by integral plastic connecting walls which space the opposed planar side portions of the support member from each other. An opening in the post portion permits ballast to be loaded into the hollow interior of the legs. A single support member can be used in combination with a vertical member having portions which snap fit with the apertures to form a three-legged sign or light support. Pairs of support members can be used with a variety of disclosed cross bar arrangements to form barricades and warning signs. The snapfit design of several of the disclosed warning devices permits the devices to come apart when hit by a vehicle without causing damage to either the vehicle or the warning device.
摘要翻译： 用于形成各种交通警示装置的中空成型塑料支撑构件具有倒置的Y形，其形成一对间隔开的成角度的腿和垂直的柱部分。 柱部分包括一对垂直细长的间隔开的孔，该孔由整体的塑料连接壁限定，其将支撑构件的相对的平面侧部彼此间隔开。 柱部分中的开口允许将镇流器装载到腿的中空内部。 单个支撑构件可以与具有与孔卡扣配合的部分的垂直构件组合使用以形成三足迹符号或光支撑。 成对的支撑构件可用于各种公开的横杆布置以形成路障和警告标志。 许多公开的报警装置的搭扣设计允许设备在被车辆撞击时分离而不会对车辆或警告装置造成损坏。
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35.发明申请System and method for integrating devices for servicing a device-under-service 有权用于集成用于维修服务中的设备的设备的系统和方法公开(公告)号：US20120047291A1
公开(公告)日：2012-02-23
申请号：US12913184
申请日：2010-10-27
IPC分类号： G06F3/00
CPC分类号： G06F13/10 , G07C5/008 , G07C5/0825 , G07C2205/02
摘要： A system comprising multiple devices that are operable when servicing a device-under service is described. A data acquisition (DAQ) device and a scanner device of the system are operable to acquire data from the device-under-service and to transmit the acquired data to a display device of the system. The DAQ device can operate in a local-control mode in which selection of DAQ mode for the DAQ device is carried out at the DAQ device. The DAQ device can operate in a remote-control mode in which selection of a DAQ mode for the DAQ device is carried out at the display device. The multiple devices may communicate with each other via one or more wireless network via one or more air interface protocols. Each device of the system may operate as a stand-alone device or in combination with multiple devices of the system.
摘要翻译： 描述了包括在服务于正在服务的设备时可操作的多个设备的系统。 系统的数据采集（DAQ）设备和扫描仪设备可操作以从服务中的设备获取数据，并将获取的数据发送到系统的显示设备。 DAQ设备可以在DAQ设备中执行DAQ设备的DAQ模式选择的本地控制模式下工作。 DAQ设备可以在远程控制模式下操作，其中在显示设备上执行DAQ设备的DAQ模式的选择。 多个设备可以经由一个或多个空中接口协议经由一个或多个无线网络彼此通信。 系统的每个设备可以作为独立设备操作，或者与系统的多个设备组合。
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36.发明授权公开(公告)号：US08008323B2
公开(公告)日：2011-08-30
申请号：US12759664
申请日：2010-04-13
IPC分类号： A61K31/47 , A61K31/445
CPC分类号： A61K31/4468 , A61K9/20 , A61K31/194 , A61K45/06 , C07C59/255 , C07D211/58 , A61K2300/00
摘要： Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
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37.发明授权公开(公告)号：US07713995B2
公开(公告)日：2010-05-11
申请号：US11416594
申请日：2006-05-03
申请人： David M. Weiner , Robert E. Davis , Mark R. Brann , Norman Nash , Carl-Magnus A. Andersson , Allan K. Uldam
发明人： David M. Weiner , Robert E. Davis , Mark R. Brann , Norman Nash , Carl-Magnus A. Andersson , Allan K. Uldam
IPC分类号： A61K31/47
CPC分类号： A61K31/4468 , A61K9/20 , A61K31/194 , A61K45/06 , C07C59/255 , C07D211/58 , A61K2300/00
摘要： Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
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38.发明授权Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases 有权选择性5-羟色胺2A / 2C受体反向激动剂作为神经变性疾病的治疗剂公开(公告)号：US07601740B2
公开(公告)日：2009-10-13
申请号：US10759561
申请日：2004-01-15
IPC分类号： A61K31/47 , A61K31/445 , C07D211/56
CPC分类号： A61K31/4468 , A61K9/20 , A61K31/194 , A61K45/06 , C07C59/255 , C07D211/58 , A61K2300/00
摘要： Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
摘要翻译： 与式（I）化合物（一种新型和选择性的5HT2A / 2C受体反向激动剂）的行为药理学数据证明了在精神病和运动障碍模型中的体内功效。 这包括逆转MK-801诱导的运动行为的活动，表明该化合物可能是MPTP灵长类运动障碍模型中有效的抗精神病药和活性，表明作为抗运动障碍剂的功效。 这些数据支持5HT2A / 2C受体反向激动作用可能赋予人类抗精神病和抗运动障碍功效的假说，并表明使用式（I）化合物和相关药物作为帕金森病，相关人类神经变性疾病的新疗法， 和精神病。
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39.发明申请Apparatus and method to update and maintain a tire pressure monitoring tool 审中-公开更新和维护轮胎压力监测工具的装置和方法公开(公告)号：US20080164846A1
公开(公告)日：2008-07-10
申请号：US11650473
申请日：2007-01-08
CPC分类号： B60C23/04 , H02J7/0044
摘要： A dock has a cradle and at least one port for recharging and communicating with a tire pressure monitoring tool. The dock recognizes that the tool is inserted into the dock; evaluates the programming in the memory; compares the programming in the memory against programming stored in a computer; determines whether the programming in the memory is older than the programming stored in the computer; and if the programming in the memory is older than the programming in the computer, then loads the programming from the computer into the memory.
摘要翻译： 码头有一个支架和至少一个端口，用于对轮胎压力监测工具进行充电和通信。 码头识别出工具插入码头; 评估内存中的编程; 将存储器中的编程与存储在计算机中的编程进行比较; 确定存储器中的编程是否比存储在计算机中的编程更早; 并且如果存储器中的编程比计算机中的编程更旧，则将编程从计算机加载到存储器中。
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40.发明授权Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass 失效用于诊断和治疗关节炎疾病和调节骨量的方法和组合物公开(公告)号：US07005274B1
公开(公告)日：2006-02-28
申请号：US09661848
申请日：2000-09-14
申请人： Robert Terkeltaub , Anne N. Murphy , James A. Dykens , Soumitra S. Ghosh , Robert E. Davis , Andrew E. Granston, Jr.
发明人： Robert Terkeltaub , Anne N. Murphy , James A. Dykens , Soumitra S. Ghosh , Robert E. Davis , Andrew E. Granston, Jr.
IPC分类号： C12Q1/02
CPC分类号： G01N33/5088 , G01N33/6887 , G01N2333/4722 , G01N2333/495 , G01N2333/78 , G01N2400/40 , G01N2800/102 , G01N2800/105
摘要： The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
摘要翻译： 本发明涉及通过比较改变的线粒体功能的一个或多个指示剂的水平，用于早期发现人类关节炎疾病的风险的改进的诊断方法以及用于治疗关节炎疾病的治疗剂的筛选测定。 改变线粒体功能的指标包括线粒体酶和ATP生物合成因子等酶。 改变的线粒体功能的其他指标包括线粒体质量，线粒体数量和线粒体DNA含量，细胞内升高的钙和凋亡细胞的反应以及自由基生成。 还提供了用于治疗和分层人类患者的方法，这些方法涉及公开的改变的脑膜功能指标。
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