公开(公告)号：US12004494B2

公开(公告)日：2024-06-11

申请号：US17475116

申请日：2021-09-14

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Seung-Joo Lee

IPC: A01K67/027 ,  A01K67/0275 ,  A01K67/0276 ,  C07K14/705 ,  C12N15/85

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  C07K14/7056 ,  C07K14/70596 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/07 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US11976119B2

公开(公告)日：2024-05-07

申请号：US17707637

申请日：2022-03-29

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Wei-Hsien Ho ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/40 ,  C07K16/42 ,  C12N15/85

CPC classification number: C07K16/283 ,  C07K16/246 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/40 ,  C07K16/4283 ,  C12N15/85 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11965023B2

公开(公告)日：2024-04-23

申请号：US17740100

申请日：2022-05-09

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07K16/2803 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240082395A1

公开(公告)日：2024-03-14

申请号：US18454286

申请日：2023-08-23

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Seung-Joo Lee

IPC: A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K39/39558 ,  A61P31/00 ,  A61P35/00 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: The invention provides anti-SIRPA antibodies, methods of generating such antibodies, and therapeutic uses and methods employing the antibodies.

公开(公告)号：US11779642B2

公开(公告)日：2023-10-10

申请号：US16463062

申请日：2017-12-08

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Seung-Joo Lee

IPC: A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K39/39558 ,  A61P31/00 ,  A61P35/00 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: The invention provides anti-SIRPA antibodies, methods of generating such antibodies, and therapeutic uses and methods employing the antibodies.

公开(公告)号：US11667699B2

公开(公告)日：2023-06-06

申请号：US16943123

申请日：2020-07-30

Applicant: Alector LLC

Inventor： Jeonghoon Sun ,  Wei-Hsien Ho ,  Muhammad A. Alhawagri ,  Philip Ling Kong ,  Herve Rhinn ,  Hua Long ,  Karpagam Srinivasan ,  Ananya Mitra ,  Daniel P. Bermingham ,  Klaus-Dieter Heger ,  Santiago Viveros Salazar ,  Francesca Cignarella ,  Ilaria Tassi ,  Tina Schwabe ,  Angie Grace Yee ,  Arnon Rosenthal

IPC: C07K16/18 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11472877B2

公开(公告)日：2022-10-18

申请号：US16078965

申请日：2017-03-03

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal ,  Helen Lam ,  Francesca Avogadri-Connors ,  Seung-Joo Lee

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220289844A1

公开(公告)日：2022-09-15

申请号：US17707637

申请日：2022-03-29

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Wei-Hsien Ho ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/40 ,  C07K16/42 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11359014B2

公开(公告)日：2022-06-14

申请号：US16614302

申请日：2018-05-15

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61P37/00 ,  A61P25/28 ,  A61P31/04 ,  A61P25/00 ,  A61P25/08 ,  A61P29/00 ,  A61P35/00 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210277113A1

公开(公告)日：2021-09-09

申请号：US17256508

申请日：2019-06-28

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPβ1 polypeptide, e.g., a human SIRPβ1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.