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31.Prevention and treatment of ocular neovascularization using angiostatic steroids 失效
标题翻译: 使用血管抑制类固醇预防和治疗眼新生血管形成公开(公告)号:US5770592A
公开(公告)日:1998-06-23
申请号:US895184
申请日:1997-07-16
申请人: Abbot F. Clark
发明人: Abbot F. Clark
IPC分类号: A61F9/007 , A61K31/56 , A61K31/565 , A61K31/569 , A61K31/57 , A61P27/02 , C07J3/00 , C07J5/00 , C07J9/00 , C07J11/00 , C07J41/00 , C07J51/00 , A61K31/33
CPC分类号: A61K31/573 , A61K31/56 , A61K31/565 , A61K31/57 , C07J11/00 , C07J3/00 , C07J41/0005 , C07J41/0027 , C07J5/0053 , C07J51/00 , C07J9/00 , Y10S514/912
摘要: Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.
摘要翻译: 公开了使用血管抑制类固醇治疗眼新生血管形成的方法和制剂。
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32.Angiostatic steroids and methods and compositions for controlling ocular hypertension 失效
标题翻译: 静脉注射类固醇以及用于控制高眼压症的方法和组合物公开(公告)号:US5698545A
公开(公告)日:1997-12-16
申请号:US643387
申请日:1996-05-06
申请人: Abbot F. Clark , Raymond E. Conrow
发明人: Abbot F. Clark , Raymond E. Conrow
IPC分类号: A61K31/56 , A61K31/565 , A61K31/57 , A61K31/58 , A61K31/665 , C07J3/00 , C07J5/00 , C07J9/00 , C07J11/00 , C07J41/00 , C07J51/00
CPC分类号: A61K31/569 , A61K31/56 , A61K31/565 , A61K31/57 , A61K31/573 , A61K31/58 , A61K31/665 , C07J11/00 , C07J3/00 , C07J41/0005 , C07J41/0027 , C07J5/0053 , C07J51/00 , C07J9/00
摘要: Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed. In addition, the combination of the compounds with glucocorticoids for the prevention of elevated IOP during the treatment of inflammation is disclosed.
摘要翻译: 公开了用于控制高眼压症的止血类固醇。 公开了血管抑制类固醇的药物组合物及其用于治疗高眼压症的方法,包括控制与原发性开角型青光眼相关的眼压高血压。 此外,公开了在治疗炎症期间化合物与糖皮质激素的组合用于预防升高的IOP。
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公开(公告)号:US5521168A
公开(公告)日:1996-05-28
申请号:US322250
申请日:1994-10-13
申请人: Abbot F. Clark
发明人: Abbot F. Clark
IPC分类号: A61K31/567 , A61K31/33 , A61K31/56
CPC分类号: A61K31/567 , Y10S514/913
摘要: Methods for lowering and controlling intraocular pressure using estrogen metabolites are disclosed.
摘要翻译: 公开了使用雌激素代谢物降低和控制眼内压的方法。
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34.RNAI-MEDIATED INHIBITION OF GREMLIN FOR TREATMENT OF IOP-RELATED CONDITIONS 审中-公开
标题翻译: 用于治疗与眼压有关的病症的RNAI介导的GREMLIN抑制剂公开(公告)号:US20120077864A1
公开(公告)日:2012-03-29
申请号:US13281785
申请日:2011-10-26
申请人: Jon E. Chatterton , Abbot F. Clark
发明人: Jon E. Chatterton , Abbot F. Clark
IPC分类号: A61K31/713 , A61P27/02 , A61P27/06 , A61K31/7105
CPC分类号: A61K31/7105 , C12N15/1136 , C12N2310/14
摘要: RNA interference is provided for inhibition of gremlin in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma.
摘要翻译: 提供了RNA干扰,用于抑制眼内压相关病症中的白蛋白,包括高眼压症和青光眼,如正常眼压青光眼和开角型青光眼。
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35.RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma 有权
标题翻译: RNAi介导的卷曲相关蛋白-1抑制治疗青光眼公开(公告)号:US07947660B2
公开(公告)日:2011-05-24
申请号:US11373376
申请日:2006-03-10
CPC分类号: C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要: RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
摘要翻译: 提供RNA干扰用于抑制卷曲相关蛋白-1 mRNA表达,特别是用于治疗患有青光眼或有发展青光眼风险的患者。
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36.
公开(公告)号:US20110054008A1
公开(公告)日:2011-03-03
申请号:US12912061
申请日:2010-10-26
申请人: Abbot F. Clark , Wan-Heng Wang , Loretta McNatt
发明人: Abbot F. Clark , Wan-Heng Wang , Loretta McNatt
IPC分类号: A61K31/7052 , A61P27/06
CPC分类号: C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/30
摘要: RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
摘要翻译: 提供RNA干扰用于抑制涉及SAA表达的青光眼中血清淀粉样蛋白A mRNA表达。
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37.
公开(公告)号:US20100152279A1
公开(公告)日:2010-06-17
申请号:US12712323
申请日:2010-02-25
申请人: Abbot F. Clark , Wan-Heng Wang , Loretta McNatt
发明人: Abbot F. Clark , Wan-Heng Wang , Loretta McNatt
IPC分类号: A61K31/7088 , A61P27/02
CPC分类号: C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/30
摘要: RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
摘要翻译: 提供RNA干扰用于抑制涉及SAA表达的青光眼中血清淀粉样蛋白A mRNA表达。
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38.Bone morphogenic proteins (BMP), BMP receptors and BMP binding proteins and their use in the diagnosis and treatment of glaucoma 有权
标题翻译: 骨形态发生蛋白(BMP),BMP受体和BMP结合蛋白及其在青光眼诊断和治疗中的应用公开(公告)号:US07405192B2
公开(公告)日:2008-07-29
申请号:US10286152
申请日:2002-10-31
IPC分类号: A61K38/00
CPC分类号: G01N33/5023 , A61K45/06 , C12Q1/6883 , C12Q2600/158 , G01N33/5041 , G01N2333/51
摘要: The present invention provides methods and kits for diagnosing and treating glaucoma.
摘要翻译: 本发明提供用于诊断和治疗青光眼的方法和试剂盒。
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39.Use of non-feminizing estrogens as retinoprotective agents for the treatment of glaucoma 失效
标题翻译: 使用非女性化雌激素作为治疗青光眼的视网膜保护剂公开(公告)号:US07384926B2
公开(公告)日:2008-06-10
申请号:US11754710
申请日:2007-05-29
申请人: Iok-Hou Pang , Abbot F. Clark
发明人: Iok-Hou Pang , Abbot F. Clark
IPC分类号: A61K31/56
CPC分类号: A61K31/56
摘要: The invention provides pharmaceutical compositions containing non-feminizing estrogen and methods of using these compositions to prevent or ameliorate retinal and optic nerve damage associated with glaucoma.
摘要翻译: 本发明提供含有非女性化雌激素的药物组合物和使用这些组合物以预防或改善与青光眼有关的视网膜和视神经损伤的方法。
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公开(公告)号:US06177427B1
公开(公告)日:2001-01-23
申请号:US09346424
申请日:1999-07-01
申请人: Abbot F. Clark , Raymond E. Conrow
发明人: Abbot F. Clark , Raymond E. Conrow
IPC分类号: A61K31415
CPC分类号: C07D231/12 , C07D207/08 , C07D213/36 , C07D233/62 , C07D249/08 , C07D249/12 , C07D295/088 , C07D401/06 , C07D405/06
摘要: Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.
摘要翻译: 公开了用于治疗青光眼或高眼压症的非甾体糖皮质激素拮抗剂的组合物及其使用方法。
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