摘要:
There is provided a compound of formula I, wherein Y1, Y2, Y3, Y4, Z1, Z2, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for use in the treatment of spinal cord injury.
摘要:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要:
There is provided a compound of formula I, wherein Y1, Y2, Y3, Y4, Z1, Z2, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for use in the treatment of spinal cord injury.
摘要:
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要:
Provided are trisamide compounds and compositions containing the same. In an embodiment, the trisamides are represented by the following formula: wherein R1 represents a univalent group other than hydrogen, and X1 and X2 represent independently selected univalent groups.
摘要:
There is provided a compound of formula I, wherein Y1, Y2, Y3, Y4, Z1, Z2, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for use in the treatment of spinal cord injury.
IMIDAZOLO-C(-Z) WHEREIN X IS A CARBON-CARBON BOND, OXYGEN, SULFUR, ETHYLENE OR VINYLENE; Y IS HYDROGEN OR HALOGEN; AND Z IS LOWER ALKYL, LOWER ALKENYL, LOWER ALKYNYL OR CYCLOALKYL OF 3 TO 6 CARBON ATOMS, ARE PREPARED FROM THIONYL-BID-IMIDAZOLE AND THE APPROPRIATE FUSED DIBENZOCARBINOL. A TYPICAL EMBODIMENT IS 9METHYL-9-IMIDAZOLYLFLUORENE.
WHEREIN X IS A CARBON-CARBON BOND, OXYGEN, SULFUR, ETHYLENE OR VINYLENE; Y IS HYDROGEN OR HALOGEN; AND Z IS LOWER ALKYL, LOWER ALKENYL, LOWER ALKYNYL OR CYCLOALKYL OF 3 TO 6 CARBON ATOMS, ARE PREPARED FROM THIONYL-BIS-IMIDAZOLE AND THE APPROPRAITE FUSED DIBENZOCARBINO. A TYPICAL EMBODIMETN IS 9METHYL-9-IMIDAZOLYLFULORENE.