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31.发明授权Intravenous system for delivering a beneficial agent using permeability enhancers 失效使用渗透性增强剂输送有益剂的静脉内系统
公开(公告)号：US5250028A
公开(公告)日：1993-10-05
申请号：US741477
申请日：1991-08-09
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion using permeation enhancers and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.
摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过使用渗透促进剂的壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。
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公开(公告)号：US5232438A
公开(公告)日：1993-08-03
申请号：US898618
申请日：1992-06-15
申请人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
发明人： Felix Theeuwes , J. Richard Gyory , Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0444
摘要： A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
摘要翻译： 一种膜，当没有电流流动时能够抑制剂量从递送系统释放，并且对电辅助剂递送提供最小的阻抗，对于并入电转运剂递送系统和用于体外测定中的测定剂释放速率是有用的 。
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公开(公告)号：US5203768A
公开(公告)日：1993-04-20
申请号：US735126
申请日：1991-07-24
申请人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
发明人： Ronald P. Haak , Felix Theeuwes , J. Richard Gyory
CPC分类号： A61N1/0448 , A61K9/0009 , A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
摘要翻译： 提供具有活性药物储存器（24）和被动药物储存器（26）的透皮药物递送装置（20）。 药物通过离子电渗从活性药物储存器（24）通过由电源（21）产生的电场积极递送。 同时，药物通过被动（即非电辅助）扩散从被动储存器（26）输送。 在一个实施例中，被动药物储存器（26）与活性药物贮存器（24）电绝缘。 在第二实施方案中，活性和被动药物都包含在相同的储存器（34）中。 在第二实施方案中，活性药物是可离子化的，而被动药物是不可离子化的。 最优选地，活性药物是被动药物的可离子化形式（即盐形式）。
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公开(公告)号：US5198229A
公开(公告)日：1993-03-30
申请号：US710607
申请日：1991-06-05
IPC分类号： A61K9/00
CPC分类号： A61K9/0065 , A61K9/0004
摘要： The present invention is directed to a fluid-imbibing drug delivery device having a first, low density such that it floats in the stomach contents for a predetermined prolonged period of time, during which prolonged period of time it dispenses a drug or other active agent to the stomach, and having a second, higher density such that the device exits the stomach at the end of the predetermined prolonged period of time.
摘要翻译： 本发明涉及一种流体吸收药物递送装置，其具有第一低密度，使得其在胃内容物中漂浮预定的较长时间段，在此期间，其将药物或其它活性剂分配到 胃，并且具有第二较高密度，使得装置在预定的较长时间段结束时离开胃。
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公开(公告)号：US5006346A
公开(公告)日：1991-04-09
申请号：US350482
申请日：1989-05-11
申请人： David E. Edgren , Felix Theeuwes
发明人： David E. Edgren , Felix Theeuwes
CPC分类号： A61K9/0004 , A61K9/2866 , A61K9/2886
摘要： A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
摘要翻译： 公开了包含围绕药物的外套的剂型。 该涂层包括底涂层和外涂层热退火以在药物周围提供单一的单一涂层。
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公开(公告)号：US4994031A
公开(公告)日：1991-02-19
申请号：US338691
申请日：1989-04-17
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
摘要翻译： 公开了一种配制腔，其包括围绕包含用于递送有益剂的装置的内腔的壁。 腔室具有用于允许流体进入腔室的入口和用于使药剂制剂离开腔室的出口。 腔室适用于静脉输送系统，用于将药剂配制物递送给患者。
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公开(公告)号：US4985016A
公开(公告)日：1991-01-15
申请号：US311905
申请日：1989-02-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.
摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。
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公开(公告)号：US4957494A
公开(公告)日：1990-09-18
申请号：US283631
申请日：1988-12-13
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
摘要翻译： 一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。 分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。 出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。 壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。 可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。
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39.发明授权
公开(公告)号：US4915949A
公开(公告)日：1990-04-10
申请号：US312270
申请日：1989-02-21
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
摘要翻译： 公开了用于将微小丸剂递送到使用环境的分配器。 所述分配器包括围绕内部空间的壁，所述壁包括所述分配器中的第一平均值，用于在离开所述分配器时从分配器状态改变为使用状态，所述第一装置中的小丸和用于辅助的所述分配器中的第二装置 在移动分配器的第一装置时。
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40.发明授权
公开(公告)号：US4871360A
公开(公告)日：1989-10-03
申请号：US854452
申请日：1986-04-21
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber. The chamber can additionally comprise a film for regulating the rate of release from the chamber, and optionally a filter. The chamber is adapted for use in an intraveous delivery system for delivering the fluid containing the agent to a patient. A method also is disclosed for using the formulation chamber.
摘要翻译： 公开了一种配制腔，其包括围绕包含有益剂的空间的壁。 制剂腔室具有用于将流体进入腔室的入口和用于使含有药剂的流体离开腔室的出口。 该室还可以包括用于调节从室释放的速率的膜，以及可选的过滤器。 该腔室适用于内部输送系统，用于将含有药剂的流体输送给患者。 公开了一种使用制剂室的方法。
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