公开(公告)号：US20210381013A1

公开(公告)日：2021-12-09

申请号：US17131930

申请日：2020-12-23

Applicant: BASF SE

Inventor： Michael BREUER ,  Wolfgang SIEGEL ,  Stefan RÜDENAUER ,  Ralf PELZER

IPC: C12P17/04

Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.

公开(公告)号：US20190292147A1

公开(公告)日：2019-09-26

申请号：US16462992

申请日：2017-11-20

Applicant: BASF SE

Inventor： Bernd SCHAEFER ,  Wolfgang SIEGEL

IPC: C07C403/24

Abstract: The invention describes a process for making astacene of formula 1, the exocyclic double bonds thereof having either an E configuration or an E- and/or Z-configuration, wherein astaxanthin of the general formula 2 having asymmetric centers 3 and 3′, each of which respectively having an (S)- or (R)-conformation and the exocyclic double bonds of said astaxanthin 2 having either an E- or E- and/or Z configuration, is oxidized in the presence of at least one tertiary alcoholate.

公开(公告)号：US20180273458A1

公开(公告)日：2018-09-27

申请号：US15743153

申请日：2016-07-08

Applicant: BASF SE

Inventor： JULIA STRAUTMANN ,  Stefan RÜDENAUER ,  Christian REIN ,  Melanie WEINGARTEN ,  Rocco PACIELLO ,  Wolfgang SIEGEL ,  Michael BREUER ,  Peter HOFMANN ,  Sebastian SCHMIDT

IPC: C07C45/50 ,  C07C47/21 ,  C07C29/141 ,  C07C29/56 ,  C07C33/025 ,  B01J31/18

CPC classification number: C07C45/50 ,  B01J31/186 ,  B01J31/1865 ,  B01J2231/321 ,  C07C29/141 ,  C07C29/56 ,  C07C33/025 ,  C07C47/21 ,  C07C2531/18 ,  C07D307/92

Abstract: The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.

公开(公告)号：US20180230176A1

公开(公告)日：2018-08-16

申请号：US15510268

申请日：2015-09-11

Applicant: BASF SE

Inventor： MICHAEL PUHL ,  Klaus DITRICH ,  Andreas KELLER ,  Pepa DIMITROVA ,  Melanie WEINGARTEN ,  Wolfgang SIEGEL

IPC: C07H15/26 ,  C07H3/06 ,  C07H1/00 ,  A23L33/10

CPC classification number: C07H15/26 ,  A23L33/10 ,  A23V2002/00 ,  C07H1/00 ,  C07H3/06

Abstract: The present invention relates to a method for preparing 2′-O-fucosyllactose, the 2′-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(═O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.

公开(公告)号：US20170233338A1

公开(公告)日：2017-08-17

申请号：US15502827

申请日：2015-07-23

Applicant: BASF SE

Inventor： Bernd SCHÄFER ,  Wolfgang SIEGEL

IPC: C07C403/24 ,  B01J31/22

CPC classification number: C07C403/24 ,  B01J31/0222 ,  B01J31/2291 ,  B01J31/2295 ,  B01J2231/645 ,  B01J2531/821 ,  C07B2200/07 ,  C07C2601/16

Abstract: The invention relates to a method for the non-stereoselective and also for the stereoselective synthesis of astaxanthin from astacin. For this purpose, a reducing agent is used selected from the group of hydrogen, a secondary alcohol, formic acid and also the salts of formic acid or from a mixture of at least two representatives of the compound classes stated above. The invention further relates to the use of astacin as starting compound for the synthesis of astaxanthin.

公开(公告)号：US20160194273A1

公开(公告)日：2016-07-07

申请号：US14987960

申请日：2016-01-05

Applicant: BASF SE

Inventor： Melanie WEINGARTEN ,  Wolfgang SIEGEL

IPC: C07C213/06

CPC classification number: C07C213/06 ,  C07B2200/07 ,  C07C217/08

Abstract: Process for the etherification of amino alcohols with metal alcoholatesA process for the preparation of the ether of formula I where R1 and R2 independently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, R3 is an alkyl group with 1 to 10 carbon atoms andX is a bond or a hydrocarbon group with 1 to 10 carbon atomscomprisinga) deprotonating the amino alcohol of formula II where R1, R2 and X have the meaning abovewith a metal alcoholate as deprotonating agent to give the anion of formula III where R1, R2 and X have the meaning aboveandb) alkylation of the anion obtained in step a) with an alkylation agent to give the ether of formula I,wherein the deprotonating agent in step a) is used in equimolar or less than equimolar amounts compared to the amino alcohol andthe alkylation agent in step b) is used in equimolar or less than equimolar amounts compared to the anion of formula III.

Abstract translation: 氨基醇与金属醇化物醚化的方法制备其中R 1和R 2彼此独立地为氢或具有1至10个C原子的烷基的式I的醚的方法，R 3是具有1至 10个碳原子，X是具有1至10个碳原子的键或烃基，包括a）使式II的氨基醇去质子化，其中R 1，R 2和X具有上述含义，用金属醇化物作为去质子化剂，得到 式III其中R 1，R 2和X具有上述含义，和b）用烷基化剂在步骤a）中获得的阴离子烷基化得到式I的醚，其中步骤a）中的去质子化剂以等摩尔或更少 与步骤b）中的氨基醇和烷基化剂相比，等摩尔量与式III的阴离子等摩尔或小于等摩尔量使用。