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公开(公告)号：US20180148753A1
公开(公告)日：2018-05-31
申请号：US15509993
申请日：2015-06-30
申请人： BASF SE
发明人： Vaidotas NAVICKAS , Kai-Uwe BALDENIUS , Michael BREUER , Patricia WILDBERGER , Martin PFEIFFER , Bernd NIDETZKY
IPC分类号： C12P19/02
CPC分类号： C12P19/02 , C07H1/02 , C07H11/04 , C12N9/1051 , C12N9/16 , C12P19/26 , C12Y204/01 , C12Y204/01007 , C12Y301/0301
摘要： The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.
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2.发明申请公开(公告)号：US20190119665A1
公开(公告)日：2019-04-25
申请号：US16212287
申请日：2018-12-06
申请人： BASF SE
发明人： Michael BREUER , Bernhard HAUER , Dieter JENDROSSEK , Gabriele SIEDENBURG , Juergen PLEISS , Demet SIRIM , Silvia FADENRECHT
CPC分类号： C12N9/88 , C12N9/90 , C12P5/007 , C12P7/02 , C12P7/22 , C12Y406/01 , C12Y504/99017 , Y02P20/52
摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
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公开(公告)号：US20180073047A1
公开(公告)日：2018-03-15
申请号：US15559962
申请日：2016-02-19
申请人： BASF SE
发明人： Vaidotas NAVICKAS , Michael BREUER , Michael PUHL , Melanie WEINGARTEN , Kai-Uwe BALDENIUS , Wofgang SIEGEL
CPC分类号： C12P19/02 , C12N9/0006 , C12N9/0065 , C12Y101/03009 , C12Y111/01006 , C12Y111/01007
摘要： The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.
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4.发明申请公开(公告)号：US20230041211A1
公开(公告)日：2023-02-09
申请号：US17786127
申请日：2020-12-15
申请人： BASF SE
发明人： Michael BREUER , Julia Ena HARTIG , Robert THUMMER , Heike BRUESER , Stephanie RENZ , Michael Guenter BRAUN , Oliver OSWALD , Roland MINGES , Jens O. KROEMER , Heiko BABEL
摘要： The invention pertains to novel methods to increase the tolerance of microbial host cells to toxic substance, for example terpenes and alcohols and other membrane disrupting substances, as well as modified organism with such an increased tolerance a compared to the unmodified organism.
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公开(公告)号：US20190144899A1
公开(公告)日：2019-05-16
申请号：US15999299
申请日：2017-02-20
申请人： BASF SE
IPC分类号： C12P17/04
摘要： The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
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公开(公告)号：US20210381013A1
公开(公告)日：2021-12-09
申请号：US17131930
申请日：2020-12-23
申请人： BASF SE
发明人： Michael BREUER , Wolfgang SIEGEL , Stefan RÜDENAUER , Ralf PELZER
IPC分类号： C12P17/04
摘要： The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
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公开(公告)号：US20180273458A1
公开(公告)日：2018-09-27
申请号：US15743153
申请日：2016-07-08
申请人： BASF SE
发明人： JULIA STRAUTMANN , Stefan RÜDENAUER , Christian REIN , Melanie WEINGARTEN , Rocco PACIELLO , Wolfgang SIEGEL , Michael BREUER , Peter HOFMANN , Sebastian SCHMIDT
IPC分类号： C07C45/50 , C07C47/21 , C07C29/141 , C07C29/56 , C07C33/025 , B01J31/18
CPC分类号： C07C45/50 , B01J31/186 , B01J31/1865 , B01J2231/321 , C07C29/141 , C07C29/56 , C07C33/025 , C07C47/21 , C07C2531/18 , C07D307/92
摘要： The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.
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8.发明申请公开(公告)号：US20170233780A1
公开(公告)日：2017-08-17
申请号：US15514706
申请日：2015-09-28
申请人： BASF SE
发明人： Michael BREUER , Ralf PELZER
IPC分类号： C12P17/06 , C07D311/92
CPC分类号： C12P17/06 , C07D311/92 , C12N9/90 , C12Y504/99017
摘要： The present invention relates to a novel process for cyclizing geranyllinalool using the squalene-hopene cyclase from Zymomonas mobilis (Zm-SHC) or a cyclase with at least 80% sequence identity to the Zm-SHC, and cyclization products obtained in this process.
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