-
公开(公告)号：US11008399B2
公开(公告)日：2021-05-18
申请号：US17077376
申请日：2020-10-22
Applicant: GENMAB A/S
Inventor： David Satijn , Esther C. W. Breij , Bart E. C. G. De Goeij , Kristel Kemper , Patrick Engelberts , Edward N. Van Den Brink , Rik Rademaker , Dennis Verzijl , Sjeng Horbach , Paul Parren
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
-
公开(公告)号：US10793640B2
公开(公告)日：2020-10-06
申请号：US15627921
申请日：2017-06-20
Applicant: GENMAB A/S
Inventor： Bart De Goeij , Edward N. Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC: C07K16/30 , A61K39/395 , C07K16/32 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
-
公开(公告)号：US10765743B2
公开(公告)日：2020-09-08
申请号：US16248402
申请日：2019-01-15
Applicant: GENMAB A/S
Inventor： Esther Breij , David Satijn , Edward Norbert Van Den Brink , Dennis Verzijl , Rob N. De Jong , Paul Parren , Riemke Van Dijkhuizen Radersma
IPC: A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00 , C07K16/30
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
-
公开(公告)号：US10597464B2
公开(公告)日：2020-03-24
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
-
公开(公告)号：US10407501B2
公开(公告)日：2019-09-10
申请号：US15110414
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Isil Altintas , Paul Parren , Rik Rademaker
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
-
Patent Agency Ranking
公开(公告)号：US09663578B2
公开(公告)日：2017-05-30
申请号：US14317600
申请日：2014-06-27
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Paul Parren , Jan Van De Winkel , Aran Frank Labrijn , Frank Everhardus Martinus Rebers , Esther Cornelia Wilhelmina Breij
IPC: A61K39/395 , C07K16/28 , A61K39/00
CPC classification number: C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
-
公开(公告)号：US20140303356A1
公开(公告)日：2014-10-09
申请号：US14353962
申请日：2012-10-26
Applicant: GENMAB A/S
Inventor： Michael Gramer , Amitava Kundu , Ewald T. J. Van Den Bremer , Muriel Van Kamper , Patrick Priem , Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Janine Schuurman , Paul Parren , Patrick Van Berkel , Werner L. Vos , Arnout Gerritsen
CPC classification number: C07K1/1133 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/732 , C07K2317/734 , C07K2317/90
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
Abstract translation: 本发明涉及用于生产异二聚体蛋白质的体外方法。
-
公开(公告)号：US11795214B2
公开(公告)日：2023-10-24
申请号：US16399424
申请日：2019-04-30
Applicant: GENMAB A/S
Inventor： Paul Parren , Patrick Van Berkel , Ewald Van Den Bremer
CPC classification number: C07K16/18 , C07K16/00 , G01N33/5014 , G01N33/6854 , C07K2317/51 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/734
Abstract: Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.
-
公开(公告)号：US11578141B2
公开(公告)日：2023-02-14
申请号：US16667369
申请日：2019-10-29
Applicant: GENMAB A/S
Inventor： Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
-
公开(公告)号：US11512140B2
公开(公告)日：2022-11-29
申请号：US16548883
申请日：2019-08-23
Applicant: GENMAB A/S
Inventor： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
IPC: C07K16/30 , G01N33/574 , A61P35/00 , A61K39/395 , C07K16/28 , A61K45/06 , C07K16/40 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
-
-
-
-
-
-
-
-
-
Search Results
64
records
(took 0.062 seconds)
