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54 条记录 (耗时 0.026 秒)

    Imidazo quinoline compounds useful as anti-allergy agents
    31.
    发明授权
    Imidazo quinoline compounds useful as anti-allergy agents 失效
    咪唑喹啉化合物可用作抗过敏剂

    公开(公告)号：US4656281A

    公开(公告)日：1987-04-07

    申请号：US731689

    申请日：1985-05-08

    申请人： John H. Musser ,  Richard E. Brown

    发明人： John H. Musser ,  Richard E. Brown

    IPC分类号： C07D215/28 ,  C07D498/04 ,  C07D471/04

    CPC分类号： C07D215/28

    摘要： The quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,Y is nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl aralkyl, acyl, aminoalkyl, or carboxyalkyl,Z is nitrogen,X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, andm is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or intermediates in the preparation of compounds useful for treating asthma.

    摘要翻译： 喹啉化合物具有下式：其中R1和R2独立地是氢，低级烷基，卤素，三氟甲基，氨基，低级烷基氨基，低级酰氨基，氰基，芳基，芳基/低级亚烷基，硝基 低级炔基，低级烯基，低级烷基亚磺酰基，低级烷基磺酰基，低级烷氧基羰基，羧基，低级烷氧基，低级烷酰基或低级烯酰基，Y为氮或R3N，其中R3为氢，低级烷基，烯基，炔基，芳基芳烷基， 酰基，氨基烷基或羧基烷基，Z是氮，X是氰基，甲酰氧基，羧基，甲酰肟基，四唑基，烷氧基烷基或羧基烷基，m是0或1，可用作药物，特别是用于治疗哮喘和/ 可用于治疗哮喘的化合物的制备。

    Morpholino containing indolothiopyrones
    35.
    发明授权
    Morpholino containing indolothiopyrones 失效
    含有吲哚硫thio酮的吗啉代

    公开(公告)号：US4064123A

    公开(公告)日：1977-12-20

    申请号：US685040

    申请日：1976-05-10

    申请人： Richard E. Brown

    发明人： Richard E. Brown

    IPC分类号： C07D209/30 ,  C07D495/04

    CPC分类号： C07D495/04 ,  C07D209/30

    摘要： This invention relates to novel indolothiopyrones having the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen or halogen; and R.sub.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, nitro-substituted-aryl, or .omega.-substituted lower alkyl wherein the substituent is: ##STR2## wherein R.sub.4 and R.sub.5 each represent hydrogen, lower alkyl, or together with the nitrogen atom, form a heterocyclic ring; and R.sub.6 is lower alkoxy or amino, and novel intermediates used in their preparation. The indolothiopyrones are prepared by reacting a 3-mercaptoindole with sodium propiolate or a substituted sodium propiolate followed by acidification to obtain an intermediate acid; the intermediate acid cyclizes in the presence of an acid catalyst to obtain the indolothiopyrone structure which may be additionally subjected to halogenation, alkylation or hydrolysis to obtain derivatives having the various substituent groups disclosed. The compounds of this invention are useful in the treatment of angina pectoris and conditions benefiting from the depression of the central nervous system.

    摘要翻译： 本发明涉及具有下式的新的吲哚硫噻酮：其中R 1是氢，低级烷基或芳基; R2是氢或卤素; 并且R 7是氢，低级烷基，低级烯基，低级炔基，硝基取代的芳基或ω-取代的低级烷基，其中取代基是：其中R 4和R 5各自代表氢，低级烷基或与氮一起 原子，形成杂环; 并且R6是低级烷氧基或氨基，并且其制备中使用的新型中间体。 吲哚硫代吡喃是通过使3-巯基吲哚与丙炔酸钠或取代的丙酸炔丙酯反应，然后酸化得到中间体酸制备的; 中酸在酸催化剂的存在下环化，得到吲哚硫酮吡喃酮结构，其可另外进行卤化，烷基化或水解，得到具有所公开的各种取代基的衍生物。 本发明的化合物可用于治疗心绞痛和受益于中枢神经系统抑制的病症。

    Indolothiopyrones
    37.
    发明授权
    Indolothiopyrones 失效
    吲哚啉酮

    公开(公告)号：US4032537A

    公开(公告)日：1977-06-28

    申请号：US684618

    申请日：1976-05-10

    申请人： Richard E. Brown

    发明人： Richard E. Brown

    IPC分类号： C07D209/30 ,  C07D495/04 ,  C07D209/04

    CPC分类号： C07D495/04 ,  C07D209/30

    摘要： This invention relates to novel indolothiopyrones having the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or aryl; R.sub.2 is hydrogen or halogen; and R.sub.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, nitro-substituted-aryl, or .omega.-substituted lower alkyl wherein the substituent is: ##STR2## wherein R.sub.4 and R.sub.5 each represent hydrogen, lower alkyl, or together with the nitrogen atom, form a heterocyclic ring; and R.sub.6 is lower alkoxy or amino, and novel intermediates used in their preparation. The indolothiopyrones are prepared by reacting a 3-mercaptoindole with sodium propiolate or a substituted sodium propiolate followed by acidification to obtain an intermediate acid; the intermediate acid cyclizes in the presence of an acid catalyst to obtain the indolothiopyrone structure which may be additionally subjected to halogenation, alkylation or hydrolysis to obtain derivatives having the various substituent groups disclosed. The compounds of this invention are useful in the treatment of angina pectoris and conditions benefitting from the depression of the central nervous system.

    Mold release composition containing tungsten disulfide
    38.
    发明授权
    Mold release composition containing tungsten disulfide 失效
    含二硫化钨的脱模剂组合物

    公开(公告)号：US3968302A

    公开(公告)日：1976-07-06

    申请号：US582311

    申请日：1975-05-30

    申请人： Richard E. Brown

    发明人： Richard E. Brown

    IPC分类号： B22C3/00 ,  C03B40/02 ,  B32B5/16 ,  C03B39/00 ,  C10M1/10

    CPC分类号： B22C3/00 ,  C03B40/02 ,  Y10T428/25 ,  Y10T428/256 ,  Y10T428/264 ,  Y10T428/265

    摘要： A composition and method of preparation are herein described for molten release and parting compositions adaptable for use in glass-forming operations. The novel composition comprise a mixture containing tungsten disulfide, a silicate and a setting agent. A preferred composition comprises a mixture of tungsten disulfide and graphite with sodium silicate and zinc oxide as a setting agent.

    摘要翻译： 本文描述了适于用于玻璃形成操作的熔融释放和分型组合物的组合物和制备方法。 该新型组合物包含含有二硫化钨，硅酸盐和凝固剂的混合物。 优选的组合物包含二硫化钨和石墨与硅酸钠和氧化锌作为固化剂的混合物。

    Automatic print failure detection and correction
    40.
    发明授权
    Automatic print failure detection and correction 有权
    自动打印故障检测和校正

    公开(公告)号：US08879085B2

    公开(公告)日：2014-11-04

    申请号：US12924084

    申请日：2010-09-20

    申请人： Michael J. VanDemark ,  Richard E. Brown

    发明人： Michael J. VanDemark ,  Richard E. Brown

    IPC分类号： G06F15/00 ,  B41J2/32 ,  B41J3/60 ,  B41J2/36 ,  G06K1/12 ,  B41J29/393 ,  G06K5/02

    CPC分类号： B41J3/60 ,  B41J2/32 ,  B41J2/36 ,  B41J29/393 ,  G06K1/121 ,  G06K5/02

    摘要： Automatic print failure detection and correction are presented. An image is produced on media as it passes through a printer, the image produced by a first print head of the printer. The image is then inspected as it appears on the media for a predefined quality level. When the quality level is unacceptable, remote network notifications can be sent from the printer for proactive maintenance to be performed on the printer. In addition, when the quality level is unacceptable, a copy of the image can be automatically reproduced on an opposite side of the media using a different print head of the printer.

    摘要翻译： 介绍了自动打印故障检测和校正。 当介质通过打印机时，图像在打印机的第一打印头产生的图像上产生。 然后在图像出现在媒体上以预定的质量水平进行检查。 当质量水平不可接受时，可以从打印机发送远程网络通知，以便在打印机上进行主动维护。 此外，当质量水平不可接受时，可以使用打印机的不同打印头在介质的相对侧上自动再现图像的副本。