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公开(公告)号：US20160368923A1
公开(公告)日：2016-12-22
申请号：US15221142
申请日：2016-07-27
发明人： Andrew K. Dilger , James R. Corte , lndawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J.P. Pinto , Michael J. Orwat , Leon M. Smith II
IPC分类号： C07D471/18 , C07D519/00 , C07F7/08 , C07D487/08 , C07D471/08
CPC分类号： C07D471/18 , C07D471/08 , C07D487/08 , C07D519/00 , C07F7/0814
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 或立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US09453018B2
公开(公告)日：2016-09-27
申请号：US14872546
申请日：2015-10-01
发明人： Andrew K. Dilger , James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J. P. Pinto , Michael J. Orwat , Leon M. Smith, II
IPC分类号： C07D471/18 , C07D487/08 , C07B59/00 , C07D471/08 , C07D519/00
CPC分类号： C07D471/18 , C07D471/08 , C07D487/08 , C07D519/00 , C07F7/0814
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US09133163B2
公开(公告)日：2015-09-15
申请号：US14081094
申请日：2013-11-15
发明人： Bruce A. Ellsworth , Jun Shi , William R. Ewing , Elizabeth A. Jurica , Andres S. Hernandez , Ximao Wu
IPC分类号： C07D401/14 , C07D401/12 , A61K31/454 , A61K45/06 , A61K31/4545 , A61P3/10
CPC分类号： C07D401/12 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
摘要翻译： 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR40G蛋白偶联受体调节剂。
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公开(公告)号：US20150203492A1
公开(公告)日：2015-07-23
申请号：US14419002
申请日：2013-08-02
发明人： Wu Yang , James R. Corte , Paul J. Gilligan , Donald J.P. Pinto , William R. Ewing , Andrew K. Dilger , Yufeng Wang , Tianan Fang , Kumar B. Pabbisetty , Leon M. Smith, II
IPC分类号： C07D471/08 , C07D401/04 , C07D487/08 , C07D471/18 , C07H17/02
CPC分类号： C07D471/08 , C07C53/18 , C07D401/04 , C07D471/18 , C07D487/08 , C07D487/18 , C07H17/02
摘要： The present invention provides compounds of Formula (X): (Formula (X), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（X）的化合物：（式（X））或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是选择性因子XIa抑制剂或FXIa的双重抑制剂 血浆激肽释放酶。本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US10208068B2
公开(公告)日：2019-02-19
申请号：US15879619
申请日：2018-01-25
发明人： Donald J. P. Pinto , James R. Corte , Wu Yang , William R. Ewing
IPC分类号： C07D471/08 , C07D487/08 , C07D498/08 , C07D519/00 , C07D471/06 , C07D487/06 , C07D498/06
摘要： The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US10160750B2
公开(公告)日：2018-12-25
申请号：US15735322
申请日：2016-06-16
IPC分类号： C07D403/14 , C07D401/04 , C07D401/14 , C07D403/12 , A61P7/02
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20180162821A1
公开(公告)日：2018-06-14
申请号：US15837034
申请日：2017-12-11
IPC分类号： C07D225/06 , C07D403/04 , C07D401/04 , C07D471/04 , C07D471/08 , C07D487/08 , C07D245/06 , A61P7/02
CPC分类号： C07D225/06 , A61P7/02 , C07D245/06 , C07D401/04 , C07D403/04 , C07D471/04 , C07D471/08 , C07D487/08
摘要： The present invention provides compounds of Formula (I): P-Ma (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20180141932A1
公开(公告)日：2018-05-24
申请号：US15735322
申请日：2016-06-16
IPC分类号： C07D403/14 , C07D401/14 , C07D401/04 , C07D403/12 , A61P7/02
CPC分类号： C07D403/14 , A61P7/02 , C07D401/04 , C07D401/14 , C07D403/12
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US09902742B2
公开(公告)日：2018-02-27
申请号：US15437605
申请日：2017-02-21
发明人： Donald J. P. Pinto , James R. Corte , Paul J. Gilligan , Tianan Fang , Leon M. Smith, II , Yufeng Wang , Wu Yang , William R. Ewing
IPC分类号： C07D487/08 , C07D519/00 , C07D471/08 , C07D498/08
CPC分类号： C07D519/00 , C07D471/06 , C07D471/08 , C07D487/06 , C07D487/08 , C07D498/06 , C07D498/08
摘要： The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US09656963B2
公开(公告)日：2017-05-23
申请号：US14442624
申请日：2013-11-15
IPC分类号： C07D231/06 , C07D403/12 , C07D231/08 , C07D401/10 , C07D403/04 , C07D401/04 , C07D401/12 , C07D403/10 , C07D413/04 , A61K45/06 , A61K31/4155 , A61K31/415 , A61K31/506 , A61K31/497 , A61K31/422 , A61K31/4439
CPC分类号： C07D231/06 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K45/06 , C07D231/08 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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