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48 条记录 (耗时 0.036 秒)

    Aldolase catalytic antibody
    32.
    发明授权
    Aldolase catalytic antibody 有权
    醛缩酶催化抗体

    公开(公告)号：US06368839B1

    公开(公告)日：2002-04-09

    申请号：US09440995

    申请日：1999-11-16

    申请人： Carlos F. Barbas, III ,  Richard A. Lerner ,  Juergen Wagner

    发明人： Carlos F. Barbas, III ,  Richard A. Lerner ,  Juergen Wagner

    IPC分类号： C12N900

    CPC分类号： C12P7/26 ,  C12N9/0002 ,  C12N9/88 ,  G01N2333/901

    摘要： Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.

    摘要翻译： 通过用反应性化合物进行免疫来产生抗体，所述反应性化合物通过形成稳定的血浆蛋白酰胺即共价抗体/半抗原复合物共价地捕获抗体结合口袋中的赖氨酸（Lys）残基。 所得催化抗体采用模拟天然I类醛缩酶所用催化机制的催化机制。

    Phage particle diagnostic reagents
    36.
    发明授权
    Phage particle diagnostic reagents 有权

    公开(公告)号：US09658224B2

    公开(公告)日：2017-05-23

    申请号：US12085618

    申请日：2006-11-14

    申请人： Donald Siegel ,  Carlos F. Barbas, III

    发明人： Donald Siegel ,  Carlos F. Barbas, III

    IPC分类号： C12N7/02 ,  C12Q1/00 ,  G01N33/53 ,  A61K39/00 ,  A61K39/395 ,  G01N33/555 ,  G01N33/68

    CPC分类号： G01N33/555 ,  G01N33/6854

    摘要： The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage.

    Tyrosine bioconjugation through aqueous Ene-like reactions
    37.
    发明授权
    Tyrosine bioconjugation through aqueous Ene-like reactions 失效
    酪氨酸生物缀合通过水溶性类似的反应

    公开(公告)号：US08765920B2

    公开(公告)日：2014-07-01

    申请号：US13518353

    申请日：2010-12-23

    申请人： Carlos F. Barbas, III ,  Hitoshi Ban ,  Julia Gavrilyuk

    发明人： Carlos F. Barbas, III ,  Hitoshi Ban ,  Julia Gavrilyuk

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C07D249/00

    CPC分类号： A61K47/48723 ,  A61K31/4196 ,  A61K31/439 ,  A61K31/47 ,  A61K47/6891 ,  C07D249/00 ,  C07D249/12 ,  C07D403/14 ,  C07D417/10

    摘要： A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.

    摘要翻译： 报道了一种新的多功能一类环状重氮二酰胺，通过Ene样反应有效和选择性地与苯酚和酪氨酸的侧链反应。 这种温和的水性酪氨酸连接反应在广泛的pH范围内起作用，并扩展了可用于小分子，肽和蛋白质修饰的水性化学成分。 显示酪氨酸连接反应与缓冲水溶液中天然酶和抗体的标记相容。 该反应为双特异性抗体提供了新的合成方法。 该反应将在肽和蛋白质化学和含酚化合物的化学中发现广泛的用途。

    EFGR antibodies comprising modular recognition domains
    38.
    发明授权
    EFGR antibodies comprising modular recognition domains 有权
    包含模块识别结构域的EFGR抗体

    公开(公告)号：US08557243B2

    公开(公告)日：2013-10-15

    申请号：US13135789

    申请日：2011-07-14

    申请人： Carlos F. Barbas, III

    发明人： Carlos F. Barbas, III

    IPC分类号： C07K16/28 ,  C07K16/46 ,  C07K19/00 ,  A61K38/00

    CPC分类号： C07K16/468 ,  A61K38/2013 ,  C07K16/2863 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2319/00

    摘要： Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described.

    摘要翻译： 描述了可以用于将抗体靶向特定位点的含有一个或多个模块识别结构域（MRD）的抗体。 还描述了使用含有一个或多个模块识别结构域的抗体来治疗疾病，以及制备含有一个或多个模块识别结构域的抗体的方法。