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公开(公告)号:US20060241151A1
公开(公告)日:2006-10-26
申请号:US11415454
申请日:2006-05-02
申请人: Wenge Zhong , Mark Norman , Matthew Kaller , Thomas Nguyen , Robert Rzasa , Christopher Tegley , Hui-Ling Wang
发明人: Wenge Zhong , Mark Norman , Matthew Kaller , Thomas Nguyen , Robert Rzasa , Christopher Tegley , Hui-Ling Wang
IPC分类号: A61K31/4439 , C07D417/02
CPC分类号: C07D417/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要: Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also realtes to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 选择的化合物对于治疗疾病如细胞增殖或细胞凋亡介导的疾病是有效的。 本发明包括新型化合物,类似物,前药及其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及中风,癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07053088B2
公开(公告)日:2006-05-30
申请号:US10445170
申请日:2003-05-20
申请人: Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Vassil I. Ognyanov , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Liping H. Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
发明人: Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Vassil I. Ognyanov , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Liping H. Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
IPC分类号: A61K31/50
CPC分类号: C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20050275128A1
公开(公告)日:2005-12-15
申请号:US10866740
申请日:2004-06-15
申请人: Li-Chen Hsiao , Chien-Chang Lin , Hui-Ling Wang , Peng-Yi Kuo
发明人: Li-Chen Hsiao , Chien-Chang Lin , Hui-Ling Wang , Peng-Yi Kuo
CPC分类号: B29D35/122 , A43B1/02 , A43B13/02 , B29C44/12 , B29C70/58 , B29K2105/16
摘要: A method for manufacturing foam material for shoes includes the steps of acquiring coconut shells, crushing the coconut shells into small pieces, grinding the coconut shell pieces into coconut fiber powder, mixing the coconut fiber powder with glue as well as foaming material, making the mixture of the coconut fiber powder and the foaming material foam in molds, and finishing, in which the foam mixture are cut into insoles of shoes after having been taken out of the molds, and in which middle soles and outsoles of shoes are directly formed in those the molds that are used for making middle soles and outsoles.
摘要翻译: 制造鞋用泡沫材料的方法包括以下步骤:获取椰子壳,将椰子壳破碎成小块,将椰壳碎片研磨成椰子纤维粉末,将椰子纤维粉末与胶以及发泡材料混合,制成混合物 的椰子纤维粉末和发泡材料在模具中发泡,并进行精加工,其中将泡沫混合物从模具中取出后被切割成鞋子的鞋垫,并且其中中间鞋底和鞋底直接形成在那些 用于制造中间鞋底和外底的模具。
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公开(公告)号:US20050267163A1
公开(公告)日:2005-12-01
申请号:US11195302
申请日:2005-08-01
申请人: Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Vassil I. Ognyanov , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Liping H. Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
发明人: Elizabeth M. Doherty , Jiawang Zhu , Markian Stec , Mark H. Norman , Vassil I. Ognyanov , Christopher H. Fotsch , Ning Chen , Partha P. Chakrabarti , Liping H. Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
IPC分类号: A61K31/4709 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P27/02 , A61P29/00 , A61P37/08 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4439 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号: C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20050176726A1
公开(公告)日:2005-08-11
申请号:US11056568
申请日:2005-02-11
申请人: Hui-Ling Wang , Chenera Balan , Elizabeth Doherty , James Falsey , Vijay Gore , Jodie Katon , Mark Norman
发明人: Hui-Ling Wang , Chenera Balan , Elizabeth Doherty , James Falsey , Vijay Gore , Jodie Katon , Mark Norman
IPC分类号: C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/506 , C07D43/14
CPC分类号: C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译: 嘧啶醚和含有它们的组合物,用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管性综合征,紧张性头痛,一般炎症,关节炎,风湿性疾病,骨关节炎 ,炎症性肠病,炎症性眼病,炎症性或不稳定性膀胱病,银屑病,皮肤炎症成分炎症,慢性炎性病症,炎性疼痛及相关的痛觉过敏和异常性疼痛,神经性疼痛及相关的痛觉过敏和异常性疼痛,糖尿病性神经病疼痛,灼痛,交感神经痛 维持疼痛,输血综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸系统内脏运动紊乱,泌尿生殖道,胃肠道或血管区域,伤口,烧伤,过敏性皮肤反应,瘙痒,白癜风,一般胃肠道疾病,胃溃疡, 杜 腹部溃疡,腹泻,坏死因子诱导的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。
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公开(公告)号:US06822097B1
公开(公告)日:2004-11-23
申请号:US10360226
申请日:2003-02-06
申请人: Mark H. Norman , Hui-Ling Wang , Robert Rzasa , Wenge Zhong , Thomas Nguyen , Matthew Kaller , Hu Liu
发明人: Mark H. Norman , Hui-Ling Wang , Robert Rzasa , Wenge Zhong , Thomas Nguyen , Matthew Kaller , Hu Liu
IPC分类号: C07D21516
CPC分类号: C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
摘要: Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 选择的化合物对于治疗疾病如细胞增殖或细胞凋亡介导的疾病是有效的。 本发明包括新型化合物,类似物,前药及其药学上可接受的衍生物,用于预防和治疗疾病和其它疾病或涉及中风,癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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