公开(公告)号：US10123996B2

公开(公告)日：2018-11-13

申请号：US15181284

申请日：2016-06-13

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC: A61K31/436 ,  A61K45/06 ,  A61K31/365 ,  A61K31/427 ,  A61K9/00

Abstract: A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, isomers, or N-oxides thereof.

公开(公告)号：US09855156B2

公开(公告)日：2018-01-02

申请号：US15043331

申请日：2016-02-12

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Vinayak Bhat

IPC: A61F2/06 ,  A61F2/89 ,  A61F2/915

CPC classification number: A61F2/89 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/0036 ,  A61F2250/0067

Abstract: A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex.

公开(公告)号：US09480588B2

公开(公告)日：2016-11-01

申请号：US14697537

申请日：2015-04-27

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Vinayak Bhat

IPC: A61F2/91 ,  A61F2/915 ,  A61L31/06 ,  A61L31/14 ,  A61L31/18 ,  A61F2/958 ,  A61F2/89

CPC classification number: A61F2/91 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0071 ,  A61F2230/001 ,  A61F2240/001 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/148 ,  A61L31/18 ,  C08L67/04

Abstract: A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex or bulbous and optionally, where at least some of the abluminal surface regions may be concave.

Abstract translation: 一种由可降解材料形成的可生物降解的支架假体，其具有多个管腔，外侧和侧表面区域，其中在至少一些结构元件的囊腔和腔表面区域之间延伸的表面部分是凸起或球形，并且任选地， 至少一些外侧表面区域可以是凹形的。

公开(公告)号：US20160128849A1

公开(公告)日：2016-05-12

申请号：US14998288

申请日：2015-12-23

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Motasim Sirhan ,  Brett Cryer ,  Vinayak Bhat

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/02 ,  A61F2/06 ,  A61F2/07 ,  A61F2/90 ,  A61F2210/0004 ,  A61F2220/0058 ,  A61F2250/003 ,  A61F2250/0067 ,  B23K26/0006 ,  B23K26/0624 ,  B23K26/355 ,  B23K26/382 ,  B23K26/40 ,  B23K2101/06 ,  B23K2103/02 ,  B23K2103/12 ,  B23K2103/50

Abstract: Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.

公开(公告)号：US20140350659A1

公开(公告)日：2014-11-27

申请号：US14450137

申请日：2014-08-01

Applicant: Elixir Medical Corporation

Inventor： Xiaoxia Zheng ,  John Yan ,  Vinayak Bhat

IPC: A61L31/06 ,  C08G63/08 ,  A61L31/14

CPC classification number: A61L31/14 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/825 ,  A61F2230/0013 ,  A61F2250/0036 ,  A61L31/06 ,  A61L31/148 ,  C08G63/08 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/139 ,  C08L67/04

Abstract: Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

Abstract translation: 可生物降解的内用假体由具有理想的生物降解特性的无定形聚合物形成。 通过退火来提高这种无定形聚合物的强度以增加结晶度，而基本上不增加生物降解时间。

公开(公告)号：US20240293131A1

公开(公告)日：2024-09-05

申请号：US18655102

申请日：2024-05-03

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  Benjamyn Serna ,  Bozena Treadwell ,  John Yan

IPC: A61B17/22 ,  A61B17/00 ,  A61F2/24

CPC classification number: A61B17/22 ,  A61F2/2418 ,  A61F2/2436 ,  A61B2017/00783 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22098 ,  A61F2250/006

Abstract: Balloon catheters, sleeves, cages, and endoluminal prostheses are provided with stress-applying and spacing features coupled to expandable surfaces thereof. The stress-applying features may have blunt and/or rounded contact regions which contact tissue or calcified regions in the vasculature. The contact regions dent or fracture occlusive material on the wall of a vascular lumen and/or patient valve leaflets when expanded. The spacing features permit blood, drug, and contrast perfusion past structures expanded in the vasculature, particularly balloon catheters.

公开(公告)号：US20240033475A1

公开(公告)日：2024-02-01

申请号：US18482711

申请日：2023-10-06

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  Benjamyn Serna ,  Kim Nguyen ,  John Yan ,  Matthew Tyler Surber

IPC: A61M25/00

CPC classification number: A61M25/0052 ,  A61M25/0074 ,  A61M2202/0014

Abstract: An aspiration catheter includes a catheter body having a proximal end, a distal end, and an aspiration lumen therebetween. A distal segment comprising an expandable distal tip of the aspiration catheter comprises a membrane and an expandable supporting structure, such as a scaffold, configured to radially expand the expandable distal tip. The expandable supporting structure may include supporting elements and other features which increase resistance to collapse of the expandable membrane under vacuum or negative pressure applied to aspirate clot through the aspiration lumen in the expanded configuration.

公开(公告)号：US20230165839A1

公开(公告)日：2023-06-01

申请号：US17941888

申请日：2022-09-09

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC: A61K31/436 ,  A61K31/4525 ,  A61K45/06 ,  A61K9/00 ,  A61K31/439

CPC classification number: A61K31/436 ,  A61K31/4525 ,  A61K45/06 ,  A61K9/0004 ,  A61K31/439

Abstract: The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula:




wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2,




—O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of:




wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of:




and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.

公开(公告)号：US20220338889A1

公开(公告)日：2022-10-27

申请号：US17863265

申请日：2022-07-12

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  Benjamyn Serna ,  Bozena Treadwell ,  John Yan

IPC: A61B17/22 ,  A61F2/24

Abstract: Balloon catheters, sleeves, cages, and endoluminal prostheses are provided with stress-applying and spacing features coupled to expandable surfaces thereof. The stress-applying features may have blunt and/or rounded contact regions which contact tissue or calcified regions in the vasculature. The contact regions dent or fracture occlusive material on the wall of a vascular lumen and/or patient valve leaflets when expanded. The spacing features permit blood, drug, and contrast perfusion past structures expanded in the vasculature, particularly balloon catheters.

公开(公告)号：US20210008040A1

公开(公告)日：2021-01-14

申请号：US16879115

申请日：2020-05-20

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC: A61K31/436 ,  A61K31/4525 ,  A61K45/06 ,  A61K9/00 ,  A61K31/439

Abstract: The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, —OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.