公开(公告)号：US20230165874A1

公开(公告)日：2023-06-01

申请号：US18160519

申请日：2023-01-27

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat ,  Motasim Sirhan ,  Blaine Bueche

IPC: A61K31/5377 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/4545 ,  A61K47/26 ,  A61K9/00 ,  A61K31/55 ,  A61K31/4706 ,  A61K47/40 ,  A61K47/12 ,  A61K31/496 ,  A61K31/4412 ,  A61K31/155 ,  A61K31/436 ,  A61K31/702

CPC classification number: A61K31/5377 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/4545 ,  A61K47/26 ,  A61K9/0075 ,  A61K9/0078 ,  A61K31/55 ,  A61K31/4706 ,  A61K47/40 ,  A61K47/12 ,  A61K31/496 ,  A61K31/4412 ,  A61K31/155 ,  A61K31/436 ,  A61K31/702

Abstract: Devices, compositions, and methods are provided for inhibiting an inflammatory, fibrotic, and/or clot formation for pulmonary disease or condition in a patient. A therapeutic composition comprising a direct factor Xa inhibitor and/or a direct factor IIa inhibitor is provided. A therapeutically effective dose of the therapeutic composition is delivered to a site of the inflammatory, fibrotic, and/or clot formation pulmonary disease or condition in the patient's lung(s). The therapeutic composition may be formulated for delivery to the patient by inhalation, ventilation, instillation, ultrasound, vibration, injection, or the like. The therapeutic composition may include one or more additional therapeutically active substances and/or one or more additional pharmaceutical agents. The one or more additional therapeutically active substances and/or one or more additional pharmaceutical agents may be delivered together with the direct factor Xa inhibitor and/or direct factor IIa inhibitor or separately from the direct factor Xa inhibitor and/or factor IIa inhibitor.

公开(公告)号：US10918505B2

公开(公告)日：2021-02-16

申请号：US17017544

申请日：2020-09-10

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/915 ,  A61F2/89 ,  A61F2/90 ,  A61F2/07 ,  A61F2/82 ,  A61F2/24

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US20190231564A1

公开(公告)日：2019-08-01

申请号：US16356933

申请日：2019-03-18

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/89 ,  A61F2/90 ,  A61F2/915

CPC classification number: A61F2/89 ,  A61F2/2442 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0033 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/0031 ,  A61F2250/0036 ,  A61F2250/0048 ,  A61F2250/0067 ,  A61F2250/0071

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US20190201225A1

公开(公告)日：2019-07-04

申请号：US16293406

申请日：2019-03-05

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  Udayan G. Patel

IPC: A61F2/958 ,  A61L29/06 ,  A61L29/14

CPC classification number: A61F2/958 ,  A61L29/06 ,  A61L29/14 ,  A61M25/10 ,  A61M25/1002 ,  A61M25/104 ,  A61M29/00 ,  A61M2025/1004 ,  A61M2025/1086

Abstract: A stent or other luminal prosthesis is delivered by a catheter having a contoured balloon. The contoured balloon may include a central dome region flanked by at least one adjacent flat or cylindrical region. The central domed region and adjacent flat or cylindrical regions are joined at shallow angles to provide for an incrementally larger expansion of the center region of the stent while minimizing shear forces during expansion.

公开(公告)号：US10271976B2

公开(公告)日：2019-04-30

申请号：US16039194

申请日：2018-07-18

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/89 ,  A61F2/915 ,  A61F2/90 ,  A61F2/07 ,  A61F2/24 ,  A61F2/82

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US20180318113A1

公开(公告)日：2018-11-08

申请号：US16039194

申请日：2018-07-18

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/89

CPC classification number: A61F2/89 ,  A61F2/2442 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0033 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/0031 ,  A61F2250/0036 ,  A61F2250/0048 ,  A61F2250/0067 ,  A61F2250/0071

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US10076431B2

公开(公告)日：2018-09-18

申请号：US15921508

申请日：2018-03-14

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/06 ,  A61F2/89 ,  A61F2/90

CPC classification number: A61F2/89 ,  A61F2/2442 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0033 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/0031 ,  A61F2250/0036 ,  A61F2250/0048 ,  A61F2250/0067 ,  A61F2250/0071

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US20160045345A1

公开(公告)日：2016-02-18

申请号：US14922883

申请日：2015-10-26

Applicant: Elixir Medical Corporation

Inventor： Howard Huang ,  John Yan ,  Vinayak Bhat ,  Motasim Sirhan

IPC: A61F2/915 ,  A61L31/16 ,  A61L31/02 ,  A61L31/10 ,  A61F2/848 ,  A61F2/958

CPC classification number: A61F2/915 ,  A61F2/848 ,  A61F2/91 ,  A61F2/958 ,  A61F2002/3011 ,  A61F2220/0016 ,  A61F2230/0002 ,  A61F2230/0006 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606

Abstract: Stents are provided with scaffold structures which have low exposures when implanted in arteries and other blood vessels and lumens. The cross-sectional dimensions, materials, and patterns are controlled to provide sufficient strength and coverage while maintaining the low exposure.

Abstract translation: 支架设置有植入动脉和其他血管和腔内时具有低曝光量的支架结构。 控制横截面尺寸，材料和图案以提供足够的强度和覆盖，同时保持低曝光。