公开(公告)号：US20200032295A1

公开(公告)日：2020-01-30

申请号：US16654532

申请日：2019-10-16

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  C12N15/86 ,  A61K35/14 ,  C12N9/22 ,  A61K38/46 ,  G01N33/50 ,  C12N15/10 ,  A61K48/00 ,  A61K31/7115 ,  C07K14/195

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20190270968A1

公开(公告)日：2019-09-05

申请号：US16402175

申请日：2019-05-02

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/0789 ,  C12N5/077 ,  C12N9/16 ,  C12N15/90 ,  C12N9/22 ,  C08K5/5399 ,  C12N15/87 ,  C12P21/00 ,  A61K35/28 ,  H01L31/048

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20190008985A1

公开(公告)日：2019-01-10

申请号：US15748132

申请日：2017-08-17

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K48/00 ,  A61K9/00 ,  C12N9/22 ,  A61P1/16 ,  A61P11/00 ,  A61P29/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US20230242943A1

公开(公告)日：2023-08-03

申请号：US17821298

申请日：2022-08-22

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/87 ,  C08K5/5399 ,  C12N5/074 ,  H01L31/048 ,  C12P21/00 ,  C12N9/16 ,  C12N5/0789 ,  C12N5/077 ,  C12N15/90 ,  C12N9/22 ,  A61K35/28

CPC classification number: C12N15/87 ,  C08K5/5399 ,  C12N5/0696 ,  H01L31/048 ,  C12P21/00 ,  C12N9/16 ,  C12Y301/21 ,  C12N5/0647 ,  C12N5/0657 ,  C12N15/907 ,  C12N9/22 ,  A61K35/28 ,  C08G77/08

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20230151335A1

公开(公告)日：2023-05-18

申请号：US17958816

申请日：2022-10-03

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/074 ,  C12N5/095 ,  C12N5/077 ,  C12N5/071 ,  C12N5/0789

CPC classification number: C12N5/0696 ,  C12N5/0695 ,  C12N5/0656 ,  C12N5/0625 ,  C12N5/0647 ,  C12N5/0657 ,  C12N5/0676 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/84 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/608 ,  C12N5/0018

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20230015146A1

公开(公告)日：2023-01-19

申请号：US17820473

申请日：2022-08-17

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K48/00 ,  A61K31/7115 ,  A61P1/16 ,  A61P3/06 ,  A61P11/00 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P3/10 ,  C07K14/00 ,  C12N9/22 ,  A61K9/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US20210009505A1

公开(公告)日：2021-01-14

申请号：US16920556

申请日：2020-07-03

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Franklin Kostas ,  Christopher Rohde

IPC: C07C215/24 ,  A61K9/10 ,  A61K9/00 ,  A61K47/54

Abstract: The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

公开(公告)号：US20200325496A1

公开(公告)日：2020-10-15

申请号：US16912321

申请日：2020-06-25

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20200325447A1

公开(公告)日：2020-10-15

申请号：US16913306

申请日：2020-06-26

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/0789 ,  C12N9/16 ,  C12N9/22 ,  H01L31/048 ,  C12N5/077 ,  C08K5/5399 ,  C12N15/87 ,  A61K35/28 ,  C12N15/90 ,  C12P21/00 ,  C12N5/074

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20200157504A1

公开(公告)日：2020-05-21

申请号：US16776765

申请日：2020-01-30

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/0789 ,  A61K35/28 ,  C12N9/22 ,  C12N15/90 ,  C12N5/077 ,  C12N9/16 ,  C12P21/00 ,  C12N15/87 ,  H01L31/048 ,  C08K5/5399 ,  C12N5/074

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.