公开(公告)号：US08273890B2

公开(公告)日：2012-09-25

申请号：US12667093

申请日：2008-06-26

Applicant: Thomas Stengel ,  Mathias Schmidt ,  Steffen Weinbrenner ,  Alexander Weber ,  Petra Gimmnich ,  Volker Gekeler ,  Thomas Beckers ,  Astrid Zimmermann ,  Thomas Maier ,  Beate Schmidt ,  Florian Dehmel

Inventor： Thomas Stengel ,  Mathias Schmidt ,  Steffen Weinbrenner ,  Alexander Weber ,  Petra Gimmnich ,  Volker Gekeler ,  Thomas Beckers ,  Astrid Zimmermann ,  Thomas Maier ,  Beate Schmidt ,  Florian Dehmel

IPC: C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02 ,  A61K31/44

CPC classification number: C07D471/04

Abstract: The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.

Abstract translation: 本发明涉及式（I）的噻吩 - 咪唑并吡啶化合物，其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。

公开(公告)号：US07723523B2

公开(公告)日：2010-05-25

申请号：US11597142

申请日：2005-05-25

Applicant: Klaus Pekari ,  Thomas Baer ,  Björn Bartels ,  Mathias Schmidt ,  Thomas Beckers

Inventor： Klaus Pekari ,  Thomas Baer ,  Björn Bartels ,  Mathias Schmidt ,  Thomas Beckers

IPC: C07D471/02

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。

公开(公告)号：US07714135B2

公开(公告)日：2010-05-11

申请号：US11883596

申请日：2006-02-08

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bär ,  Thomas Beckers ,  Björn Bartels

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bär ,  Thomas Beckers ,  Björn Bartels

IPC: C07D471/02

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。

公开(公告)号：US07714134B2

公开(公告)日：2010-05-11

申请号：US11628369

申请日：2005-06-10

Applicant: Klaus Pekari ,  Thomas Baer ,  Mathias Schmidt ,  Thomas Beckers

Inventor： Klaus Pekari ,  Thomas Baer ,  Mathias Schmidt ,  Thomas Beckers

IPC: C07D471/02

CPC classification number: C07D495/04 ,  A61K31/4365

Abstract: The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.

Abstract translation: 其中Ra和Rb具有本说明书中指出的含义的某种式（1）的化合物是新型的用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。 本发明还涉及某些式（I）化合物，其中Ra和Rb具有说明书中所示的含义。

公开(公告)号：US07544066B1

公开(公告)日：2009-06-09

申请号：US12135013

申请日：2008-06-06

Applicant: Stephen Brian Lynch ,  Jason Sloey ,  Cameron Frazier ,  Mathias Schmidt

Inventor： Stephen Brian Lynch ,  Jason Sloey ,  Cameron Frazier ,  Mathias Schmidt

IPC: H01R12/00

CPC classification number: H01R12/592 ,  H01R12/721

Abstract: An electrical connector that utilizes a flexible substrate for providing electrical contact surfaces within the electrical connector is disclosed. Advantageously, the electrical contact surfaces can be precisely formed on the flexible substrate such that manual assembly of individual contacts (e.g., pins) for a connector can be avoided. In one embodiment, the flexible substrate also facilitates connection of the electrical connector to other electrical components, such as other substrates, integrated circuits, etc., without having to solder leads or pins of a connector to a printed circuit board. In one implementation, the flexible substrate can be integrally formed with a system substrate.

Abstract translation: 公开了一种电连接器，其利用柔性基板在电连接器内提供电接触表面。 有利地，可以在柔性基板上精确地形成电接触表面，从而可以避免用于连接器的单独触头（例如，引脚）的手动组装。 在一个实施例中，柔性基板还便于将电连接器连接到诸如其它基板，集成电路等的其它电气部件，而不必将连接器的引线或引脚焊接到印刷电路板。 在一个实施方案中，柔性基底可以与系统基底一体地形成。

公开(公告)号：US20090098133A1

公开(公告)日：2009-04-16

申请号：US11883624

申请日：2006-02-10

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

IPC: C07D495/04 ,  A61K31/44 ,  A61K31/4365 ,  A61K31/5377 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。

公开(公告)号：US20080206258A1

公开(公告)日：2008-08-28

申请号：US11920572

申请日：2006-05-24

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Petra Gimmnich

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Petra Gimmnich

IPC: A61K31/437 ,  C07D471/04 ,  A61K31/5377 ,  A61P35/00 ,  A61K39/395 ,  C07D413/14

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。

公开(公告)号：US20070213360A1

公开(公告)日：2007-09-13

申请号：US11597556

申请日：2005-06-03

Applicant: Klaus Pekari ,  Thomas Baer ,  Mathias Schmidt ,  Thomas Beckers

Inventor： Klaus Pekari ,  Thomas Baer ,  Mathias Schmidt ,  Thomas Beckers

IPC: A61K31/4743 ,  C07D498/02

CPC classification number: C07D495/04

Abstract: Compounds of the formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的式（I）化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。

公开(公告)号：US20060079540A1

公开(公告)日：2006-04-13

申请号：US10535815

申请日：2003-11-26

Applicant: Mathias Schmidt

Inventor： Mathias Schmidt

IPC: A61K31/522 ,  A61K31/513 ,  A61K31/473 ,  A61K31/426 ,  A61K31/277

CPC classification number: A61K31/522 ,  A61K31/00 ,  A61K31/44 ,  A61K31/501

Abstract: The invention relates to the use of a PDE4 or PDE3/4 inhibitor for the treatment of cachexia.

Abstract translation: 本发明涉及PDE4或PDE3 / 4抑制剂用于治疗恶病质的用途。

公开(公告)号：US20050267303A1

公开(公告)日：2005-12-01

申请号：US11136688

申请日：2005-05-24

Applicant: Heinz Weinberger ,  Thomas Beckers ,  Mathias Schmidt ,  Silke Baasner ,  Bernd Nickel

Inventor： Heinz Weinberger ,  Thomas Beckers ,  Mathias Schmidt ,  Silke Baasner ,  Bernd Nickel

IPC: C07D487/04 ,  C07D487/14 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D513/04 ,  C07D487/04

Abstract: The invention relates to novel, substituted, fused indole and heteroindole derivatives of the general formula I their tautomers, stereoisomers, mixtures and pharmaceutically acceptable salts, their synthesis and their use as pharmaceuticals, especially as anti-tumor agents, for mammals, especially for man.

Abstract translation: 本发明涉及通式I的新型取代的稠合吲哚和杂吲哚衍生物，它们的互变异构体，立体异构体，混合物和药学上可接受的盐，它们的合成及其作为药物特别是作为抗肿瘤剂的用途，用于哺乳动物，特别是对于人 。