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    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
    39.
    发明申请
    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof 审中-公开
    双环杂环，含有这些化合物的药物组合物，其用途及其制备方法

    公开(公告)号：US20110136806A1

    公开(公告)日：2011-06-09

    申请号：US13027669

    申请日：2011-02-15

    申请人： Frank HIMMELSBACH ,  Birgit JUNG

    发明人： Frank HIMMELSBACH ,  Birgit JUNG

    IPC分类号： A61K31/5377 ,  C07D401/12 ,  C07D413/14 ,  C07D239/94 ,  A61K31/517 ,  A61P1/00 ,  A61P35/00 ,  A61P11/00

    CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

    摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re and X are as defined in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, in particular, the physiologically-acceptable salts thereof with inorganic and organic acids with useful pharmacological properties, in particular, an inhibitory effect on signal transduction brought about by tyrosine kinases, the use thereof for the treatment of diseases, in particular of tumour diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and airways and production thereof.

    摘要翻译： 本发明涉及通式（I）的双环杂环，其中Ra，Rb，Rc，Rd，Re和X如权利要求1所定义，互变异构体，立体异构体，其混合物和盐，特别是生理上可接受的 其与具有有用药理学性质的无机和有机酸的盐，特别是对由酪氨酸激酶引起的信号转导的抑制作用，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生症（BPH），疾病 的肺和气道及其生产。

    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
    40.
    发明申请
    Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them 审中-公开
    双环杂环，含有这些化合物的药物组合物，它们的用途和制备方法

    公开(公告)号：US20100267718A1

    公开(公告)日：2010-10-21

    申请号：US12826927

    申请日：2010-06-30

    申请人： Frank HIMMELSBACH ,  Rainer Soyka ,  Birgit Jung

    发明人： Frank HIMMELSBACH ,  Rainer Soyka ,  Birgit Jung

    IPC分类号： A61K31/5377 ,  C07D239/72 ,  C07D413/12 ,  A61K31/517 ,  A61P1/00 ,  A61P11/00

    CPC分类号： C07D413/12 ,  C07D239/94

    摘要： The present invention relates to bicyclic heterocycles of general formula whereinRa, Rb, Rc, Rd, X and n are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibiting effect on the signal transduction mediated by tyrosine kinases, their use in treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract and the preparation thereof.

    摘要翻译： 本发明涉及通式的双环杂环，其中Ra，Rb，Rc，Rd，X和n如权利要求1所定义，互变异构体，立体异构体，其混合物及其盐，特别是其生理上可接受的盐与 具有有价值的药理学特性的无机或有机酸，特别是对由酪氨酸激酶介导的信号转导的抑制作用，它们在治疗疾病尤其是肿瘤疾病以及良性前列腺增生（BPH），肺和呼吸道疾病中的用途 及其制备。