利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

47 条记录 (耗时 0.047 秒)

    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
    31.
    发明授权
    Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists 失效
    吡咯烷基和吡咯啉基乙胺化合物作为κ激动剂

    公开(公告)号：US06313302B2

    公开(公告)日：2001-11-06

    申请号：US09770513

    申请日：2001-01-26

    申请人： Fumitaka Ito ,  Hiroshi Kondo

    发明人： Fumitaka Ito ,  Hiroshi Kondo

    IPC分类号： C07C23724

    CPC分类号： C07D213/82 ,  C07D207/10 ,  C07D207/12 ,  C07D207/20 ,  C07D207/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： A compound of the following formula: and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optionally substituted phenyl; Ar2 is aryl or heteroaryl selected from phenyl, napththyl, or pyridyl, the aryl or heteroaryl being optionally substituted; R1 is hydrogen, hydroxy, or C1-C4 alkyl; and R2 and R3 are independently selected from optionally substituted C1-C7 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or R2 and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine. These compounds are useful as kappa agonists.

    摘要翻译： 下式的化合物及其盐，其中A是氢，卤素或羟基; 虚线表示任选的双键，条件是如果虚线是双键，则A不存在; Ar1是任选取代的苯基; Ar2是选自苯基，萘乙基或吡啶基的芳基或杂芳基，芳基或杂芳基任选被取代; R1是氢，羟基或C1-C4烷基; 并且R 2和R 3独立地选自任选取代的C 1 -C 7烷基，C 3 -C 6环烷基，C 2 -C 6烯基，C 2 -C 6炔基或R 2和R 3与它们所连接的氮原子一起形成任选取代的 吡咯烷。 这些化合物可用作κ激动剂。

    Hydroxamic acid anesthetic compounds
    33.
    发明授权
    Hydroxamic acid anesthetic compounds 失效
    羟肟酸麻醉剂

    公开(公告)号：US5837717A

    公开(公告)日：1998-11-17

    申请号：US790246

    申请日：1997-01-28

    申请人： Fumitaka Ito

    发明人： Fumitaka Ito

    IPC分类号： C07D295/12 ,  A61K31/00 ,  A61K31/165 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/55 ,  A61P7/00 ,  A61P7/10 ,  A61P11/00 ,  A61P11/14 ,  A61P25/00 ,  A61P25/04 ,  A61P29/00 ,  C07C259/06 ,  C07D205/04 ,  C07D207/20 ,  C07D211/70 ,  C07D295/125 ,  A61K31/44 ,  C07C291/02 ,  C07D401/12

    CPC分类号： C07D295/125 ,  C07D205/04 ,  C07D207/20 ,  C07D211/70 ,  Y02P20/55

    摘要： A compound of the following formula: ##STR1## and its pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, phenyl or phenyl-C.sub.1-4 alkyl; or R.sup.1 and R.sup.2 are taken together with the nitrogen to which they are attached and form optionally substituted, saturated or unsaturated 3-, 4-, 5-, 6- or 7-membered heterocyclic cantaining one to two heteroatoms, provided that the heterocyclic is not pyrrolidinyl; R.sup.3 is hydrogen, C.sub.1-4 alkyl or a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy-C.sub.1-4 alkyloxy, CF.sub.3 and carboxy-C.sub.1-4 alkyloxy; and X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl, C.sub.1-4 alkylenedioxy, pyridyl, furyl or thienyl, these groups being optionally substituted with up to three substituents. These compounds and pharmaceutical compositions containing them are useful as analgesic, antiinflammatory, diuretic, antitussive, anesthetic or neuroprotective agents, or an agent for treatment of functional bowel disease such as abdominal pain, for the treatment of a mammalian subject, especially a human subject.

    摘要翻译： 下式的化合物：其中R1和R2独立地是氢，C1-4烷基，C3-7环烷基，C2-4链烯基，C1-4烷氧基，C1- 4-烷硫基，苯基或苯基-C 1-4烷基; 或者R 1和R 2与它们所连接的氮原子一起形成任选取代的饱和或不饱和的3-，4-，5-，6-或7-元杂环，其可以具有一至两个杂原子，条件是杂环是 不是吡咯烷基; R3是氢，C1-4烷基或羟基保护基; Ar是任选被一个或多个选自卤素，羟基，C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基-C 1-4烷氧基，CF 3和羧基-C 1-4烷氧基的取代基取代的苯基; X是苯基，萘基，联苯基，茚满基，苯并呋喃基，苯并噻吩基，1-四氢萘酮-6-基，C 1-4亚烷基二氧基，吡啶基，呋喃基或噻吩基，这些基团任选被至多三个取代基取代。 含有它们的这些化合物和药物组合物可用作止痛剂，抗炎剂，利尿剂，止咳剂，麻醉剂或神经保护剂，或用于治疗功能性肠病如腹痛的药剂，用于治疗哺乳动物受试者，特别是人类受试者。

    Method of communications between telephone and facsimile apparatus and facsimile apparatus capable of communications with telephone
    34.
    发明授权
    Method of communications between telephone and facsimile apparatus and facsimile apparatus capable of communications with telephone 失效
    电话和传真设备之间的通信方法以及能够与电话通信的传真设备

    公开(公告)号：US5748715A

    公开(公告)日：1998-05-05

    申请号：US531651

    申请日：1995-09-21

    申请人： Tetsuo Shinagawa ,  Yumiko Watanabe ,  Akio Shinagawa ,  Fumitaka Ito

    发明人： Tetsuo Shinagawa ,  Yumiko Watanabe ,  Akio Shinagawa ,  Fumitaka Ito

    IPC分类号： H04N1/00 ,  H04M11/00

    CPC分类号： H04N1/00281

    摘要： A facsimile apparatus which utilizes a dialing signal of a tone signal and can be used as a called-side communication apparatus to print desired character string information through a simple operation of a calling-side telephone set, and also a facsimile communication method in the facsimile apparatus. In the called-side facsimile apparatus, a character string information memory stores therein a plurality of character string information and unique numbers associated therewith; whereas a character information memory stores therein image information corresponding to the respective character string information. When a user of the calling-side communication apparatus enters a number corresponding to desired character string information, this causes a dialing signal indicative of the number to be transmitted to the facsimile apparatus. In the facsimile apparatus, a control unit converts to image information the character string information corresponding to the number indicated by the dialing signal detected by a dialing signal detector, and the converted image information is printed by a printer.

    摘要翻译： 使用音调信号的拨号信号的传真装置，并且可以用作被叫侧通信装置，以通过主叫侧电话机的简单操作来打印期望的字符串信息，以及传真中的传真通信方法 仪器。 在被叫侧传真装置中，字符串信息存储器中存储有与其相关联的多个字符串信息和唯一号码; 而字符信息存储器存储与各个字符串信息相对应的图像信息。 当主叫侧通信装置的用户输入与期望的字符串信息相对应的号码时，这就产生一个表示要向传真机发送的号码的拨号信号。 在传真装置中，控制单元将与由拨号信号检测器检测到的拨号信号所指示的号码相对应的字符串信息转换为图像信息，并且由打印机打印转换后的图像信息。

    Apparatus for use in offices etc.
    35.
    发明授权
    Apparatus for use in offices etc. 失效
    办公室使用的装置

    公开(公告)号：US5592189A

    公开(公告)日：1997-01-07

    申请号：US469789

    申请日：1995-06-06

    申请人： Soshiro Kuzunuki ,  Yasuro Hori ,  Shuichi Okabe ,  Fumitaka Ito

    发明人： Soshiro Kuzunuki ,  Yasuro Hori ,  Shuichi Okabe ,  Fumitaka Ito

    IPC分类号： H04N1/00 ,  G02F1/1334 ,  G09F19/12 ,  G09G3/36

    CPC分类号： G09F19/12 ,  G02F1/1334

    摘要： An apparatus for use in offices includes a planar liquid crystal shutter disposed at least a portion of a surface of a housing of the apparatus, the shutter being set to a transparent state or a non-transparent state depending on an input signal supplied thereto, and a controller for applying to the shutter a control signal to control the transparent or non-transparent state thereof.

    摘要翻译： 在办公室中使用的装置包括：平面液晶快门，其设置在装置的壳体的表面的至少一部分上，根据提供给其的输入信号，快门被设置为透明状态或非透明状态;以及 用于向快门施加控制信号以控制其透明或非透明状态的控制器。

    Apparatus and method for polishing semiconductor wafer
    38.
    发明申请
    Apparatus and method for polishing semiconductor wafer 审中-公开
    用于抛光半导体晶片的装置和方法

    公开(公告)号：US20060049142A1

    公开(公告)日：2006-03-09

    申请号：US11200172

    申请日：2005-08-10

    申请人： Fumitaka Ito

    发明人： Fumitaka Ito

    IPC分类号： C03C15/00 ,  H01L21/306 ,  B44C1/22

    CPC分类号： B08B1/007 ,  B08B3/02

    摘要： By almost completely removing foreign matter adhering to the wafer holding unit of a polishing head in a CMP process, a wafer yield is improved. An apparatus for polishing a semiconductor wafer is provided with a wafer holder to which the wafer is attached, a polishing unit which polishes the wafer with a polishing slurry supplied to the wafer, a wafer attaching and detaching unit at which the wafer is attached to or detached from the wafer holder, and a washing unit which washes the wafer holder. The wafer holder has a wafer contact surface, which contacts the backside of the wafer, and a supporting unit which prevents the jump out of the wafer. The washing unit has nozzles which supply a washing solution to the wafer contact surface and the supporting unit, and the nozzles are composed of a plurality of outlets capable of supplying at least two different liquids. As a result, it is possible to almost completely remove the foreign matter adhering to the wafer holder to always keep the wafer holder clean.

    摘要翻译： 通过在CMP工艺中几乎完全除去附着在抛光头的晶片保持单元上的异物，晶片产量提高。 用于抛光半导体晶片的装置设置有晶片保持器，晶片固定到晶片固定器上，抛光单元，其用提供给晶片的抛光浆料抛光晶片，晶片安装和分离单元，晶片附着到和/ 从晶片保持器分离，洗涤单元洗涤晶片保持器。 晶片保持器具有接触晶片背面的晶片接触表面和防止跳出晶片的支撑单元。 洗涤单元具有向晶片接触表面和支撑单元提供洗涤溶液的喷嘴，并且喷嘴由能够供应至少两种不同液体的多个出口组成。 结果，可以几乎完全除去附着在晶片保持架上的异物，以始终保持晶片保持器清洁。