-
公开(公告)号：US07329749B2
公开(公告)日：2008-02-12
申请号：US10466487
申请日：2001-12-24
申请人： Henning Boettcher , Gerd Bartoszyk , Juergen Harting , Christoph van Amsterdam , Christoph Seyfried
发明人： Henning Boettcher , Gerd Bartoszyk , Juergen Harting , Christoph van Amsterdam , Christoph Seyfried
IPC分类号： A61K31/496 , C07D403/06
CPC分类号： C07D215/48 , A61K31/495 , C07D217/26
摘要： Compound of the formula (I) in which R1, R2 and alk are as defined in Claim 1, are potent 5-HT2A antagonist and are suitable for the treatment of psychoses, schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Hutington's disease, eating disorders, such as bulimia, anorexia nervosa, premenstrual syndrome and/or for positively influencing obsessive-compulsive disorder (OCD).
摘要翻译： 其中R 1，R 2和R 2如权利要求1所定义的式（I）化合物是有效的5-HT 2A 2A 拮抗剂，适用于治疗精神病，精神分裂症，抑郁症，神经障碍，记忆障碍，帕金森病，肌萎缩性侧索硬化，阿尔茨海默氏病，Hutington氏病，进食障碍，贪食症，神经性厌食症，经前期综合征和/或正面 影响强迫症（OCD）。
-
公开(公告)号：US20050096330A1
公开(公告)日：2005-05-05
申请号：US11013908
申请日：2004-12-17
申请人： Henning Boettcher , Hartmut Greiner , Juergen Harting , Gerd Bartoszyk , Christoph Seyfried , Christoph van Amsterdam
发明人： Henning Boettcher , Hartmut Greiner , Juergen Harting , Gerd Bartoszyk , Christoph Seyfried , Christoph van Amsterdam
IPC分类号： C07D403/06 , A61K31/496 , A61P3/04 , A61P21/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/38 , C07D209/40 , C07D209/42 , C07D209/82 , C07D295/04 , C07D409/12 , C07D43/02
CPC分类号： C07D409/12 , C07D209/08
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R4 and R5 have the meaning given in Claim 1. Said compounds are potent 5-HT2A-antagonists and are suitable for the treatment of psychosis, schizophrenia, depression, neurological disorders, memory disorders. Parkinson's disease, amyntrophic lateral schlerosis, Alzheimer's disease, Huntington's disease, eating disorders, e.g. nervous bulimia and anorexia and premenstrual syndrome and/or for positively influencing compulsive behaviours (obsessive-compulsive disorder, OCD).
摘要翻译： 本发明涉及式（I）的化合物，其中R 1，R 2，R 4和R 5， 具有权利要求1中给出的含义。所述化合物是有效的5-HT 2A拮抗剂，适用于治疗精神病，精神分裂症，抑郁症，神经障碍，记忆障碍。 帕金森氏病，融合性侧脑硬化，阿尔茨海默氏病，亨廷顿病，进食障碍等。 紧张性贪食症和厌食症和经前期综合征和/或积极影响强迫性行为（强迫症，强迫症）。
-
公开(公告)号：US20050026927A1
公开(公告)日：2005-02-03
申请号：US10495456
申请日：2002-10-14
IPC分类号： C07D231/12 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/00 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P39/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D498/04 , C07D513/04 , C07
CPC分类号： C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14
摘要： The invention relates to pyrazole derivatives of Formula (I), in which R?1, X, Z and n have the meanings indicated above, their preparation and their use as psychopharmaceuticals and/or as active compounds of medicaments for the treatment and prophylaxis of movement disorders and/or for the manufacture of a medicament for the treatment of adverse effects of anti-Parkinsonian drugs in extrapyramidal movement disorders and/or for the manufacture of a medicament for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.
摘要翻译： 本发明涉及式（I）的吡唑衍生物，其中R 1 <定制字符文件=“US20050026927A1-20050203-P00900.TIF”wi =“20”he =“20”id =“custom-character-00001 “/>，X，Z和n具有上述含义，它们的制备及其作为精神药物和/或用作治疗和预防运动障碍的药物的活性化合物和/或用于制备治疗药物的用途 抗帕金森药物在锥体外系运动障碍中的不利影响和/或用于制备用于治疗由精神安定药诱发的锥体束外症状（EPS）的药物。
-
公开(公告)号：US06310068B1
公开(公告)日：2001-10-30
申请号：US08628250
申请日：1996-04-05
IPC分类号： A61K31496
CPC分类号： C07D209/14
摘要： Compound of the formula I in which Q and Ar have the meanings indicated herein, and their salts, exhibit actions on the central nervous system.
摘要翻译： Q和Ar具有本文所示含义的式Iin化合物及其盐在中枢神经系统上表现出作用。
-
公开(公告)号：US06251908B1
公开(公告)日：2001-06-26
申请号：US09462468
申请日：2000-04-03
IPC分类号： C07D40514
CPC分类号： C07D405/12
摘要： Piperazine derivatives of the formula I in which R1, m, k and R2 have the meanings indicated in claim 1, are potent 5-HT1A agonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.
摘要翻译： R1，m，k和R2具有权利要求1所述含义的式Iin的哌嗪衍生物是有效的5-HT1A激动剂，具有5-HT-再摄取抑制作用，适用于治疗和预防焦虑状态，抑郁 ，精神分裂症，痴迷症，迟发性运动障碍，学习障碍，年龄依赖性记忆障碍，积极影响强迫症，以及用于治疗和控制脑梗死如脑卒中和脑缺血的后遗症。
-
公开(公告)号：US07618988B2
公开(公告)日：2009-11-17
申请号：US10489960
申请日：2002-08-12
申请人： Henning Böttcher , Ralf Devant , Maria Devant, legal representative , Gerd Bartoszyk , Hermann Russ , Frank Weber , Christoph Seyfried
发明人： Henning Böttcher , Ralf Devant , Gerd Bartoszyk , Hermann Russ , Frank Weber , Christoph Seyfried
IPC分类号： A61K31/135 , A61K31/33 , A61K31/395 , A61K31/535 , A61K31/54 , A61K31/58
CPC分类号： C07D405/12
摘要： Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.
摘要翻译： 其中R具有权利要求1所述含义的式I化合物或其用于治疗锥体束外运动障碍和/或锥体外系运动障碍和/或治疗中的副作用的其旋光异构体或药学上可接受的盐之一 的精神分裂症引起的锥体外系症状（EPS）。
-
公开(公告)号：US20060229339A1
公开(公告)日：2006-10-12
申请号：US10489960
申请日：2002-08-12
申请人： Henning Böttcher , Ralf Devant , Maria Devant , Gerd Bartoszyk , Hermann Russ , Frank Weber , Christoph Seyfried
发明人： Henning Böttcher , Ralf Devant , Maria Devant , Gerd Bartoszyk , Hermann Russ , Frank Weber , Christoph Seyfried
IPC分类号： A61K31/4433
CPC分类号： C07D405/12
摘要： Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.
摘要翻译： 其中R具有权利要求1所述含义的式I化合物或其用于治疗锥体束外运动障碍和/或锥体外系运动障碍和/或治疗中的副作用的其旋光异构体或药学上可接受的盐之一 的精神分裂症引起的锥体外系症状（EPS）。
-
公开(公告)号：US06462056B1
公开(公告)日：2002-10-08
申请号：US09380202
申请日：1999-08-25
IPC分类号： A61K31454
CPC分类号： C07D413/14
摘要： The invention relates to novel oxazolidine derivatives of the formula in which R1, R2 and R3 have the meanings stated in claim 1, their salts and processes for preparing the compounds according to the invention. The compounds of the formula I act as 5-HT2A antagonists with a 5-HT reuptake-inhibiting, antidepressant or anxiolytic effect and can be used to produce pharmaceuticals.
摘要翻译： 本发明涉及式（1）的新的恶唑烷衍生物，其中R1，R2和R3具有权利要求1所述的含义，其盐和制备本发明化合物的方法。式I化合物作为5-HT2A拮抗剂， 5-HT再摄取抑制，抗抑郁或抗焦虑作用，可用于生产药物。
-
公开(公告)号：US06413989B1
公开(公告)日：2002-07-02
申请号：US09508059
申请日：2000-05-17
IPC分类号： A61K3145
CPC分类号： C07D413/06
摘要： The invention relates to the compound 5-[4-(4-fluorobenzyl) piperidin-1-ylmethyl]-3-(4-hydroxy-phenyl)oxazolidin-2-one of the formula I and to physiologically acceptable salts thereof. The compound acts as a neuroleptic.
摘要翻译： 本发明涉及式I的化合物5- [4-（4-氟苄基）哌啶-1-基甲基] -3-（4-羟基 - 苯基）恶唑烷-2-酮及其生理上可接受的盐。 化合物作为精神安定药物。
-
![Use of(R)-(−) -2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts](/abs-image/US/2011/04/19/US07928128B2/abs.jpg.150x150.jpg)
40.发明授权Use of(R)-(−) -2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts 有权（R） - （ - ） - 2- [5-（4-氟苯基）-3-吡啶甲基氨基甲基] - 苯并二氢吡喃及其生理学上可接受的盐公开(公告)号：US07928128B2
公开(公告)日：2011-04-19
申请号：US10221031
申请日：2001-02-01
申请人： Gerd Bartoszyk , Hermann Russ , Christoph Seyfried , Frank Weber
发明人： Gerd Bartoszyk , Hermann Russ , Christoph Seyfried , Frank Weber
CPC分类号： A61K31/353 , A61K31/4433 , A61K45/06 , A61K2300/00
摘要： (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane or a physiologically acceptable salt thereof is useful for treatment of adverse effects in treating Parkinson's disease.
摘要翻译： （R） - （ - ） - 2- [5-（4-氟苯基）-3-吡啶甲基氨基甲基] - 苯并二氢吡喃或其生理学上可接受的盐可用于治疗帕金森病的不良反应。
-
-
-
-
-
-
-
-
-
搜索结果
98 条记录 (耗时 0.046 秒)
