公开(公告)号：US10988459B2

公开(公告)日：2021-04-27

申请号：US15200058

申请日：2016-07-01

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Craig Stivala ,  Huifen Chen ,  Guiling Zhao

IPC: A61K31/551 ,  C07D487/04 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D498/04 ,  C07D495/04 ,  C07D491/04 ,  C07D491/10 ,  C07D413/14 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US10730889B2

公开(公告)日：2020-08-04

申请号：US15936086

申请日：2018-03-26

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/513

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20180153831A1

公开(公告)日：2018-06-07

申请号：US15828271

申请日：2017-11-30

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Guiling Zhao ,  Huifen Chen

IPC: A61K31/16 ,  A61K31/5383 ,  A61K31/44 ,  A61K31/4196 ,  A61K31/416 ,  A61P9/10 ,  A61K31/397 ,  A61K31/396 ,  A61P29/00 ,  A61P43/00 ,  A61K31/4025

CPC classification number: A61K31/16 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/44 ,  A61K31/5383 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P43/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US09822129B2

公开(公告)日：2017-11-21

申请号：US14382210

申请日：2013-03-01

Applicant: GENENTECH,INC. ,  FORMA TM, LLC ,  Po-Wai Yuen

Inventor： Kenneth W Bair ,  Timm R Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

CPC classification number: C07D519/00 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20170087137A1

公开(公告)日：2017-03-30

申请号：US15374047

申请日：2016-12-09

Applicant: Genentech, Inc.

Inventor： Anthony Estrada ,  Wen Liu ,  Snahel Patel ,  Michael Siu

IPC: A61K31/4439 ,  A61K31/437 ,  A61K31/4545

CPC classification number: A61K31/4439 ,  A61K31/437 ,  A61K31/4545 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04

Abstract: The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.

公开(公告)号：US09365583B2

公开(公告)日：2016-06-14

申请号：US14576890

申请日：2014-12-19

Applicant: Genentech, Inc.

Inventor： Michael Siu ,  Anthony Estrada ,  Wen Liu ,  Joseph P. Lyssikatos ,  Snahel Patel ,  Guibai Liang ,  Kevin Chen

IPC: C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D498/04 ,  C07D498/10 ,  C07D401/04

CPC classification number: C07D491/107 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D498/04 ,  C07D498/10

Abstract: The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.

Abstract translation: 本发明提供式0化合物及其各种实施方案，以及包含式0化合物及其各种实施方案的组合物。 在式0的化合物中，基团R1A，R1B，R1C，R1D，R2，R3，R4，R5和R6具有如本文所述的含义。 本发明还提供使用式0化合物和包含式0化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症的方法。

公开(公告)号：US11634436B2

公开(公告)日：2023-04-25

申请号：US17067638

申请日：2020-10-09

Applicant: Genentech, Inc.

Inventor： Snahel Patel

IPC: C07D519/00 ,  A61P1/04 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/06 ,  A61P25/16 ,  A61P25/28 ,  C07D498/04 ,  C07D471/04 ,  C07D487/04

Abstract: The invention provides compounds having the general formula I: or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R7a, R7b, X, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of use thereof.

公开(公告)号：US20230002391A1

公开(公告)日：2023-01-05

申请号：US17340082

申请日：2021-06-06

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Craig Stivala ,  Huifen Chen ,  Blake Daniels

IPC: C07D487/04 ,  C07D231/54 ,  C07D249/16 ,  A61P25/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

公开(公告)号：US11072617B2

公开(公告)日：2021-07-27

申请号：US16175206

申请日：2018-10-30

Applicant: Genentech, Inc.

Inventor： Snahel Patel ,  Gregory Hamilton ,  Craig Stivala ,  Huifen Chen ,  Blake Daniels

IPC: C07D487/04 ,  C07D231/54 ,  C07D249/16 ,  A61P25/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

公开(公告)号：US20210171545A1

公开(公告)日：2021-06-10

申请号：US16944581

申请日：2020-07-31

Applicant: Integral Early Discovery, Inc. ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D495/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/513

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.