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公开(公告)号:US09822129B2
公开(公告)日:2017-11-21
申请号:US14382210
申请日:2013-03-01
申请人: GENENTECH,INC. , FORMA TM, LLC , Po-Wai Yuen
发明人: Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC分类号: C07D519/00 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06
CPC分类号: C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号:US20180291000A1
公开(公告)日:2018-10-11
申请号:US16008378
申请日:2018-06-14
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号: C07D401/12 , C07C317/42 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D213/84 , C07D213/81 , C07D213/75 , C07D213/74 , C07D213/54 , C07D213/40
CPC分类号: C07D401/12 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07C317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号:US10772874B2
公开(公告)日:2020-09-15
申请号:US16538208
申请日:2019-08-12
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号: C07D491/048 , C07D487/04 , A61K31/4355 , A61K31/4365 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号:US20200283403A1
公开(公告)日:2020-09-10
申请号:US16824885
申请日:2020-03-20
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号: C07D401/12 , C07C317/42 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D213/40
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号:US10730889B2
公开(公告)日:2020-08-04
申请号:US15936086
申请日:2018-03-26
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC分类号: C07D519/00 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513
摘要: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号:US20190105307A1
公开(公告)日:2019-04-11
申请号:US16212360
申请日:2018-12-06
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号: A61K31/4355 , A61K31/496 , A61K31/4365 , A61K31/437 , A61K31/497 , A61K31/519 , C07D471/04 , A61K31/55 , C07D487/04 , C07D491/048 , A61K45/06 , C07D495/04 , C07D491/04 , A61K31/5377
CPC分类号: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号:US20190388405A1
公开(公告)日:2019-12-26
申请号:US16538208
申请日:2019-08-12
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号: A61K31/4355 , C07D491/048 , C07D487/04 , A61K45/06 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/497 , A61K31/496 , A61K31/437 , A61K31/4365 , C07D495/04 , C07D491/04 , C07D471/04
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号:US10329275B2
公开(公告)日:2019-06-25
申请号:US16008378
申请日:2018-06-14
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号: C07D401/12 , C07D471/04 , C07D213/54 , C07D213/75 , C07D213/81 , C07C317/42 , C07D213/74 , C07D213/84 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D213/40
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号:US10272072B2
公开(公告)日:2019-04-30
申请号:US15352184
申请日:2016-11-15
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W. Bair , Timm R. Baumeister , Alexandre Joseph Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号: A61K31/4353 , A61K31/497 , A61K31/5377 , A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
摘要: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号:US10696692B2
公开(公告)日:2020-06-30
申请号:US14382141
申请日:2013-03-01
申请人: Forma TM, LLC , Genentech, Inc.
发明人: Kenneth W Bair , Timm R Baumeister , Alexandre J Buckmelter , Karl H Clodfelter , Peter Dragovich , Francis Gosselin , Janet Gunzner-Toste , Bingsong Han , Jian Lin , Xiongcai Liu , Dominic J Reynolds , Chase C Smith , Zhongguo Wang , Mark Zak , Yamin Zhang , Guiling Zhao , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号: A61K51/00 , A61M36/14 , C07D519/00 , C07D471/04 , C07D495/04 , C07D487/04 , C07D491/048 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/551 , A61K45/06
摘要: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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