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公开(公告)号:US20250161315A1
公开(公告)日:2025-05-22
申请号:US19029035
申请日:2025-01-17
Applicant: Genentech, Inc.
Inventor: Mark X. Sliwkowski , Scott Holden , Stuart Lutzker , Jay Tibbitts , Nelson L. Jumbe
IPC: A61K31/5365 , A61K9/00 , A61K31/337 , A61K31/416 , A61K31/513 , A61K31/517 , A61K31/5355 , A61K31/5377 , A61K31/555 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/68 , C07K16/32 , G01N33/50 , G01N33/574
Abstract: Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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公开(公告)号:US20250154282A1
公开(公告)日:2025-05-15
申请号:US19027348
申请日:2025-01-17
Applicant: Genentech, Inc.
Inventor: Jeong KIM , Jeanne CHEUNG
IPC: C07K16/32 , A61K31/282 , A61K31/337 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/64 , C07K16/28 , C07K16/30
Abstract: The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.
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公开(公告)号:US12299890B2
公开(公告)日:2025-05-13
申请号:US17842542
申请日:2022-06-16
Applicant: Genentech, Inc.
Inventor: Nils Gustav Thomas Bengtsson , Richard Alan Duray Carano , Alexander James Stephen Champion De Crespigny , Jill Osborn Fredrickson , Mohamed Skander Jemaa
Abstract: Medical image(s) are input into a detection network to generate mask(s) identifying a set of regions within the medical image(s), where the detection network predicts that each region identified in the mask(s) includes a depiction of a tumor of one or more tumors within the subject. For each region, the region of the medical image(s) is processed using a tumor segmentation network to generate one or more tumor segmentation boundaries for the tumor present within the subject. For each tumor and by using a plurality of organ-specific segmentation networks, an organ is determined within which at least part of the tumor is located. An output is generated based on the one or more tumor segmentation boundaries and locations of the organs within which at least part of the one or more tumors are located.
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公开(公告)号:US12296138B2
公开(公告)日:2025-05-13
申请号:US16651440
申请日:2018-09-28
Applicant: F. HOFFMANN-LA ROCHE AG , GENENTECH, INC.
Inventor: Markus Hemminger , Ulla Grauschopf , Frank Bamberg , Mayumi Bowen , Robert Müller , Flora Felsovalyi , Denny Christensen
Abstract: A method of preparing a prefilled syringe is disclosed that includes obtaining a syringe barrel and a needle adaptor cap assembled on the tip of the syringe barrel, wherein the needle adaptor cap has a rubber element tightly sealing the orifice of the tip of the syringe barrel and the syringe barrel together with the needle adaptor cap assembled on the tip of the syringe barrel is sterilized by a first sterilizing. Filling a drug substance into an interior of the syringe barrel and sealing the interior of the syringe barrel. Packaging the syringe barrel with a rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel. Providing a second external surface sterilizing of the packaged syringe barrel with the rubber stopper sealing the interior thereof and the needle adaptor cap assembled on the tip of the syringe barrel.
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公开(公告)号:US12291712B2
公开(公告)日:2025-05-06
申请号:US17307877
申请日:2021-05-04
Applicant: Genentech, Inc.
Inventor: Karthik Veeravalli , Rebekah McKenna
Abstract: Provided herein are methods and host cells for producing a polypeptide containing two chains, such as an antibody, half-antibody, antibody fragment, or one-armed antibody. The methods and host cells allow for two-chain polypeptide production using expression of polynucleotides encoding the polypeptide chains from extra-chromosomal polynucleotide(s), and expression of one or more chaperone protein(s) (e.g., peptidyl-prolyl isomerases and/or protein disulfide oxidoreductases) from the host cell chromosome using non-native combination(s) of promoters and translational units encoding a chaperone protein.
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公开(公告)号:US12285429B2
公开(公告)日:2025-04-29
申请号:US17922804
申请日:2021-05-04
Applicant: Genentech, Inc.
Inventor: Zhilong Hu , Hu He , Fei Zhang , Wenge Zhong , Xiaotian Zhu
IPC: C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P35/00 , C07D405/14 , C07D487/04
Abstract: The invention provides a compound represented by the either of the following structural formulas, or a pharmaceutically acceptable salt, or a stereoisomer thereof, useful for treating cancer.
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公开(公告)号:US20250129063A1
公开(公告)日:2025-04-24
申请号:US18913711
申请日:2024-10-11
Applicant: Genentech, Inc.
Inventor: Jakob FUHRMANN , Alberto Emilio GOBBI , Joachim RUDOLPH
IPC: C07D417/14 , A61K31/428 , A61K45/06 , A61K47/55
Abstract: The present disclosure relates to benzothiazole compounds and to methods of using such compounds. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.
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公开(公告)号:US20250121059A1
公开(公告)日:2025-04-17
申请号:US18991315
申请日:2024-12-20
Applicant: Genentech, Inc.
Inventor: Michael ADLER , Ulla GRAUSCHOPF , Hanns-Christian MAHLER , Oliver Boris STAUCH
IPC: A61K39/395 , A61K9/00 , A61K9/08 , A61K9/19 , A61K38/47 , A61K45/06 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/42 , C07K16/32
Abstract: The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.
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公开(公告)号:US20250115618A1
公开(公告)日:2025-04-10
申请号:US18988433
申请日:2024-12-19
Applicant: Genentech, Inc.
Inventor: Christopher MCBRIDE , Lynnie Lin TRZOSS , Amogh BOLOOR , Nadezda V. SOKOLOVA , Richard M. PASTOR , Steven Thomas STABEN , Craig STIVALA , Matthew VOLGRAF , Sarah M. BRONNER
IPC: C07D498/04 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , C07D231/18 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.
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公开(公告)号:US20250109195A1
公开(公告)日:2025-04-03
申请号:US18980433
申请日:2024-12-13
Applicant: Genentech, Inc.
Inventor: Germaine FUH , Chingwei V. LEE , Patrick KOENIG
IPC: C07K16/24 , A61K39/00 , A61K39/395 , A61K45/06 , C07K16/46
Abstract: The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.
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