公开(公告)号：US11325902B2

公开(公告)日：2022-05-10

申请号：US16927178

申请日：2020-07-13

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Kristen Nicole Burford ,  Thilo Focken ,  Verner Alexander Lofstrand ,  Michael Scott Wilson ,  Alla Yurevna Zenova

IPC: C07D417/12 ,  A61P25/08 ,  C07D277/52 ,  C07D413/12

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

公开(公告)号：US11174268B2

公开(公告)日：2021-11-16

申请号：US16805895

申请日：2020-03-02

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  David Earl Bogucki ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Shannon Marie Decker ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  Qi Jia ,  James Philip Johnson, Jr. ,  Michael Scott Wilson ,  Alla Yurevna Zenova

IPC: C07D491/107 ,  C07D493/10 ,  C07D237/20 ,  C07D213/76 ,  C07D239/69 ,  C07D261/16 ,  C07D263/50 ,  C07D275/03 ,  C07D277/52 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/10 ,  C07D417/14 ,  C07D451/06 ,  A61K31/395 ,  A61K31/427

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

公开(公告)号：US10981905B2

公开(公告)日：2021-04-20

申请号：US16556055

申请日：2019-08-29

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Christoph Martin Dehnhardt ,  Thilo Focken ,  Michael Edward Grimwood ,  Qi Jia ,  Verner Alexander Lofstrand ,  Shaoyi Sun ,  Steven Sigmund Wesolowski ,  Michael Scott Wilson ,  Alla Yurevna Zenova

IPC: C07D471/04 ,  A61K31/437 ,  C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/08

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

公开(公告)号：US20190194184A1

公开(公告)日：2019-06-27

申请号：US16289212

申请日：2019-02-28

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  James Philip Johnson, JR. ,  Alla Yurevna Zenova

IPC: C07D451/06 ,  C07D285/08 ,  C07D277/52 ,  C07D493/10 ,  C07D261/16 ,  C07D417/12 ,  C07D401/12 ,  C07D239/69 ,  C07D237/20 ,  C07D213/76 ,  C07D403/12 ,  C07D417/14 ,  C07D413/12

Abstract: This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

公开(公告)号：US10246453B2

公开(公告)日：2019-04-02

申请号：US15600490

申请日：2017-05-19

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  James Philip Johnson, Jr. ,  Alla Yurevna Zenova

IPC: A61K31/4025 ,  A61K31/426 ,  A61K31/427 ,  A61K31/444 ,  C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D451/06 ,  C07D403/12 ,  C07D213/76 ,  C07D237/20 ,  C07D239/69 ,  C07D413/12 ,  C07D261/16 ,  C07D493/10 ,  C07D277/52 ,  C07D285/08

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

公开(公告)号：US20170334902A1

公开(公告)日：2017-11-23

申请号：US15600490

申请日：2017-05-19

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  James Philip Johnson, JR. ,  Alla Yurevna Zenova

IPC: C07D451/06 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D451/06 ,  C07D213/76 ,  C07D237/20 ,  C07D239/69 ,  C07D261/16 ,  C07D277/52 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

公开(公告)号：US20170114075A1

公开(公告)日：2017-04-27

申请号：US15253369

申请日：2016-08-31

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Mikhail Chafeev ,  Sultan Chowdhury ,  Lauren Fraser ,  Jianmin Fu ,  Jonathan Langille ,  Shifeng Liu ,  Jianyu Sun ,  Shaoyi Sun ,  Serguei Sviridov ,  Mark Wood ,  Alla Yurevna Zenova ,  Qi Jia ,  Jean-Jacques Alexandre Cadieux ,  Simon J. Gauthier ,  Amy Frances Douglas ,  Tom Hsieh ,  Nagasree Chakka ,  Zoran Cikojevic

IPC: C07D513/22 ,  C07D491/20 ,  C07D495/20 ,  C07D498/20 ,  C07D491/22 ,  C07D513/20 ,  C07D491/107

CPC classification number: C07D513/22 ,  C07D491/10 ,  C07D491/107 ,  C07D491/20 ,  C07D491/22 ,  C07D495/20 ,  C07D498/20 ,  C07D513/20 ,  C07D519/00

Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

公开(公告)号：US09630929B2

公开(公告)日：2017-04-25

申请号：US14355552

申请日：2012-10-30

Applicant: XENON PHARMACEUTICALS INC.

Inventor： Shaoyi Sun ,  Alla Yurevna Zenova ,  Mikhail Chafeev ,  Qi Jia ,  Zaihui Zhang ,  Renata Marcella Oballa

IPC: C07D417/12 ,  C07D239/42 ,  C07D285/08 ,  C07D401/12 ,  C07D413/12 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135

CPC classification number: C07D239/42 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/08 ,  C07D285/135 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.