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公开(公告)号：US10793640B2
公开(公告)日：2020-10-06
申请号：US15627921
申请日：2017-06-20
Applicant: GENMAB A/S
Inventor： Bart De Goeij , Edward N. Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC: C07K16/30 , A61K39/395 , C07K16/32 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US10765743B2
公开(公告)日：2020-09-08
申请号：US16248402
申请日：2019-01-15
Applicant: GENMAB A/S
Inventor： Esther Breij , David Satijn , Edward Norbert Van Den Brink , Dennis Verzijl , Rob N. De Jong , Paul Parren , Riemke Van Dijkhuizen Radersma
IPC: A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00 , C07K16/30
Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
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公开(公告)号：US10597464B2
公开(公告)日：2020-03-24
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Ewald T. J. Van Den Bremer , Joost J. Neijssen , Patrick Van Berkel , Bart De Goeij , Tom Vink , Jan Van De Winkel , Janine Schuurman , Paul Parren
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins.
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公开(公告)号：US10407501B2
公开(公告)日：2019-09-10
申请号：US15110414
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Isil Altintas , Paul Parren , Rik Rademaker
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US09663578B2
公开(公告)日：2017-05-30
申请号：US14317600
申请日：2014-06-27
Applicant: GENMAB A/S
Inventor： Edward Norbert Van Den Brink , Paul Parren , Jan Van De Winkel , Aran Frank Labrijn , Frank Everhardus Martinus Rebers , Esther Cornelia Wilhelmina Breij
IPC: A61K39/395 , C07K16/28 , A61K39/00
CPC classification number: C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
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Patent Agency Ranking
公开(公告)号：US20140303356A1
公开(公告)日：2014-10-09
申请号：US14353962
申请日：2012-10-26
Applicant: GENMAB A/S
Inventor： Michael Gramer , Amitava Kundu , Ewald T. J. Van Den Bremer , Muriel Van Kamper , Patrick Priem , Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Janine Schuurman , Paul Parren , Patrick Van Berkel , Werner L. Vos , Arnout Gerritsen
CPC classification number: C07K1/1133 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/732 , C07K2317/734 , C07K2317/90
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
Abstract translation: 本发明涉及用于生产异二聚体蛋白质的体外方法。
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公开(公告)号：US11795214B2
公开(公告)日：2023-10-24
申请号：US16399424
申请日：2019-04-30
Applicant: GENMAB A/S
Inventor： Paul Parren , Patrick Van Berkel , Ewald Van Den Bremer
CPC classification number: C07K16/18 , C07K16/00 , G01N33/5014 , G01N33/6854 , C07K2317/51 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/734
Abstract: Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.
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公开(公告)号：US11578141B2
公开(公告)日：2023-02-14
申请号：US16667369
申请日：2019-10-29
Applicant: GENMAB A/S
Inventor： Joost J. Neijssen , Joyce I. Meesters , Bart De Goeij , Aran Frank Labrijn , Paul Parren , Janine Schuurman
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
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公开(公告)号：US11512140B2
公开(公告)日：2022-11-29
申请号：US16548883
申请日：2019-08-23
Applicant: GENMAB A/S
Inventor： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
IPC: C07K16/30 , G01N33/574 , A61P35/00 , A61K39/395 , C07K16/28 , A61K45/06 , C07K16/40 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US11485796B2
公开(公告)日：2022-11-01
申请号：US16783720
申请日：2020-02-06
Applicant: GENMAB A/S
Inventor： Aran Frank Labrijn , Joyce I. Meesters , Joost J. Neijssen , Edward Norbert Van Den Brink , Janine Schuurman , Paul Parren
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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