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公开(公告)号:US20240200150A1
公开(公告)日:2024-06-20
申请号:US18594336
申请日:2024-03-04
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , C12N15/10 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , G16B30/00 , G16B30/10
CPC classification number: C12Q1/6886 , C12N15/1065 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , G16B30/00 , G16B30/10 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20240182978A1
公开(公告)日:2024-06-06
申请号:US18441187
申请日:2024-02-14
Applicant: GUARDANT HEALTH, INC.
Inventor: Stefanie Ann Ward MORTIMER , AmirAli TALASAZ , Darya CHUDOVA , Helmy ELTOUKHY
IPC: C12Q1/6886 , C12M1/00 , C12M1/34 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , G01N33/574 , G16B20/20 , G16B30/10 , G16H50/20 , G16H50/30
CPC classification number: C12Q1/6886 , C12M1/00 , C12M1/34 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , G01N33/57407 , G16B20/20 , G16B30/10 , G16H50/20 , G16H50/30 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/166
Abstract: Disclosed herein are methods, compositions, and devices for use in the early detection of cancer. The methods include preparing cell-free nucleic acid molecules from a subject for sequencing, sequencing a panel of regions in the cell-free nucleic acid molecules, and detecting one or more markers that are indicative of a cancer.
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公开(公告)号:US20240071628A1
公开(公告)日:2024-02-29
申请号:US17822058
申请日:2022-08-24
Applicant: GUARDANT HEALTH, INC.
Inventor: Helmy ELTOUKHY , AmirAli TALASAZ , Bahram Ghaffarzadeh KERMANI , Nnamdi IHUEGBU
Abstract: This disclosure provides, among other things, methods for compiling and using a database for identifying one or more therapeutic interventions for a cancer and/or the efficacy of a therapeutic intervention for subjects with a tumor genomic profile. The database may include, for each of a plurality of subjects having cancer: (i) tumor genomic testing data, including somatic alterations, collected at two or more time intervals per subject via serial biopsy of cell-free DNA, (ii) one or more therapeutic interventions administered to each of the subjects at one or more times; and (iii) efficacy of the therapeutic interventions.
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公开(公告)号:US20230151435A1
公开(公告)日:2023-05-18
申请号:US18157249
申请日:2023-01-20
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/6806 , C12Q1/6874
CPC classification number: C12Q1/6886 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/1065 , C12Q1/6806 , C12Q1/6874 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/158
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20220205051A1
公开(公告)日:2022-06-30
申请号:US17696524
申请日:2022-03-16
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/6806 , C12Q1/6874
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20220025469A1
公开(公告)日:2022-01-27
申请号:US17367245
申请日:2021-07-02
Applicant: GUARDANT HEALTH, INC.
Inventor: Stefanie Ann Ward MORTIMER , AmirAli TALASAZ , Darya CHUDOVA , Helmy ELTOUKHY
IPC: C12Q1/6886 , G16B20/20 , C12Q1/6806 , G16B30/10 , C12Q1/6869
Abstract: Disclosed herein are methods for use in detection of molecular residual disease. The methods may comprise deep sequencing a panel of genomic regions in cell-free DNA molecules and computer processing sequence reads to detect variants that are indicative of molecular residual disease.
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公开(公告)号:US20210371912A1
公开(公告)日:2021-12-02
申请号:US17396097
申请日:2021-08-06
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ , Stefanie Ann Ward MORTIMER
IPC: C12Q1/6827 , C12Q1/6806 , G16B30/00
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20210130912A1
公开(公告)日:2021-05-06
申请号:US17146359
申请日:2021-01-11
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , C12Q1/6874 , C12N15/10 , C12Q1/6806 , G16B30/00 , C12Q1/6869
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20210087616A1
公开(公告)日:2021-03-25
申请号:US17069559
申请日:2020-10-13
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ , Stefanie Ann Ward MORTIMER
IPC: C12Q1/6827 , C12Q1/6806 , G16B30/00
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20210050072A1
公开(公告)日:2021-02-18
申请号:US17011835
申请日:2020-09-03
Applicant: GUARDANT HEALTH, INC.
Inventor: Helmy ELTOUKHY , AmirAli TALASAZ
IPC: G16B40/00 , G16B20/00 , C12Q1/6886 , G16H50/20 , G16H50/30
Abstract: The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state. Such probabilities can be used to inform a health care provider as to particular courses of treatment to maximize probability of a desired outcome for the subject.
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