公开(公告)号：US07183521B2

公开(公告)日：2007-02-27

申请号：US11087311

申请日：2005-03-23

Applicant: Gary Fisher

Inventor： Gary Fisher

IPC: F24C7/08 ,  F24C16/16 ,  A21B1/40 ,  A21B1/50

CPC classification number: F24C15/16 ,  F24C7/08

Abstract: An oven having a cooking cavity and a removable rack structure has a rack sensor in the oven. The sensor provides an indication of an absence or presence of the structure and an oven control permits oven cleaning in response to the indication of the absence of the structure or prevents oven cleaning in response to the indication of the presence of the structure.

Abstract translation: 具有烹饪腔和可拆卸机架结构的烤箱在烘箱中具有齿条传感器。 传感器提供了结构的不存在或存在的指示，并且烘箱控制允许响应于结构不存在的指示而进行烘箱清洁，或者响应于结构的存在的指示来防止烘箱清洁。

公开(公告)号：US20060009494A1

公开(公告)日：2006-01-12

申请号：US11168017

申请日：2005-06-27

Applicant: John Voorhees ,  Sewon Kang ,  Gary Fisher

Inventor： John Voorhees ,  Sewon Kang ,  Gary Fisher

IPC: A61K31/4439

CPC classification number: A61K31/4439 ,  A61K8/22 ,  A61K8/671 ,  A61K31/07 ,  A61K31/41 ,  A61K2800/782 ,  A61Q19/00

Abstract: Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying acne by administering, topically or systemically, at least one of (i) an inhibitor of the matrix degrading enzymes and (ii) a cytokine inhibitor that alleviates inflammation and thus also alleviate neutrophil infiltration. Alleviating the matrix degradation and renormalizing procollagen biosynthesis allows for reduced inflammation and better natural repair of acne-affected skin. Inhibiting cytokines alleviates induction of MMPs in resident skin cells, and also alleviates inflammation with its concommitant induction of neutrophils from the blood stream bringing MMPs and elastase into the acne lesion. Dimishing the presence of matrix-degrading enzymes in the acne lesion reduces imperfect repair of the skin and thus decreases scarring in acne-affected skin.

公开(公告)号：US20050277695A1

公开(公告)日：2005-12-15

申请号：US11169072

申请日：2005-06-27

Applicant: John Voorhees ,  Gary Fisher ,  Sewon Kang

Inventor： John Voorhees ,  Gary Fisher ,  Sewon Kang

IPC: A61K8/22 ,  A61K8/67 ,  A61K31/07 ,  A61K31/41 ,  A61Q19/00 ,  A61K31/203 ,  A61K31/19

CPC classification number: A61K31/327 ,  A61K8/22 ,  A61K8/671 ,  A61K31/07 ,  A61K31/203 ,  A61K31/41 ,  A61K31/65 ,  A61K45/06 ,  A61K2800/782 ,  A61Q19/00 ,  A61K2300/00

Abstract: Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying acne by administering, topically or systemically, at least one of (i) an inhibitor of the matrix degrading enzymes and (ii) a cytokine inhibitor that alleviates inflammation and thus also alleviate neutrophil infiltration. Alleviating the matrix degradation and renormalizing procollagen biosynthesis allows for reduced inflammation and better natural repair of acne-affected skin. Inhibiting cytokines alleviates induction of MMPs in resident skin cells, and also alleviates inflammation with its concommitant induction of neutrophils from the blood stream bringing MMPs and elastase into the acne lesion. Dimishing the presence of matrix-degrading enzymes in the acne lesion reduces imperfect repair of the skin and thus decreases scarring in acne-affected skin.

Abstract translation: 已经发现受痤疮影响的皮肤伴随着基质降解酶如MMP和嗜中性粒细胞弹性蛋白酶的存在，嗜中性粒细胞的诱导和前胶原生物合成的减少。 本发明通过局部或全身地施用（i）基质降解酶的抑制剂和（ii）减轻炎症并因此也减轻嗜中性粒细胞浸润的细胞因子抑制剂中的至少一种来治疗伴随痤疮的瘢痕形成和炎症。 减轻基质降解和重塑原胶原生物合成可以减少炎症和更好的天然修复受痤疮影响的皮肤。 抑制细胞因子减轻常驻皮肤细胞中MMPs的诱导，并且还可以缓解炎症，同时从血液中诱导嗜中性粒细胞，使MMP和弹性蛋白酶进入痤疮病变。 减少痤疮病变中基质降解酶的存在降低皮肤的不完美修复，从而减少痤疮影响的皮肤中的瘢痕形成。

公开(公告)号：US20050236392A1

公开(公告)日：2005-10-27

申请号：US11093371

申请日：2005-03-30

Applicant: Chris Blackson ,  Gary Fisher ,  James Ayres ,  William Pryor

Inventor： Chris Blackson ,  Gary Fisher ,  James Ayres ,  William Pryor

IPC: F24C3/12 ,  H05B3/68

CPC classification number: F24C15/106 ,  F24C3/126 ,  H05B3/68

Abstract: A cooking device for cooking an item where the device includes an input for a source of cooking energy; a cooking element for applying the cooking energy to the item; a cooking control for controlling the application of the cooking energy to the item; a lockout selectable for preventing application of the cooking energy to the cooking element, the lockout being non-selectable when the cooking control is activated; and a user interface, the interface providing an indication of selection of the lockout in response to a user attempt to activate the cooking control when the lockout is selected.

Abstract translation: 一种用于烹饪物品的烹饪设备，其中该设备包括用于烹饪能源的输入; 用于将烹饪能量施加到所述物品的烹饪元件; 烹调控制器，用于控制烹饪能量对物品的应用; 可选择用于防止烹饪能量施加到烹饪元件的锁定，当烹饪控制被激活时，所述锁定是不可选择的; 以及用户接口，所述界面响应于当选择所述锁定时用户尝试激活所述烹饪控制，提供所述锁定的选择的指示。

公开(公告)号：US20050058709A1

公开(公告)日：2005-03-17

申请号：US10948002

申请日：2004-09-23

Applicant: Gary Fisher ,  Sewon Kang ,  James Varani ,  John Voorhees

Inventor： Gary Fisher ,  Sewon Kang ,  James Varani ,  John Voorhees

IPC: A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/64 ,  A61K8/67 ,  A61K9/22 ,  A61Q17/04 ,  A61Q19/08 ,  A61K7/42

CPC classification number: A61Q17/04 ,  A61K8/35 ,  A61K8/368 ,  A61K8/37 ,  A61K8/42 ,  A61K8/447 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/64 ,  A61K8/671 ,  A61K8/676 ,  A61K8/678 ,  A61K2800/522 ,  A61K2800/782 ,  A61K2800/92 ,  A61Q19/08

Abstract: Compositions and methods are provided for ameliorating various effects of UVA and UVB radiation, especially from the sun. The compositions include an ingredient that prevents photoaging from MED and subMED radiation, namely an MMP (matrix metalloproteinase) inhibitor, especially formulated for oral administration, and more especially formulated for controlled-release so as to provide the MMP inhibitor when MMP induction (including upstream signalling molecules like c-JUN, and/or MMPs like stromelysin) is most prevalent.

Abstract translation: 提供了组合物和方法，用于改善UVA和UVB辐射的各种作用，特别是来自太阳。 组合物包括防止MED和subMED辐射的光老化的成分，即特别配制用于口服给药的MMP（基质金属蛋白酶）抑制剂，更特别地配制用于控制释放，以便当MMP诱导时（包括上游 信号分子如c-JUN和/或MMPs如基质溶素）是最普遍的。