公开(公告)号：US08377033B2

公开(公告)日：2013-02-19

申请号：US12877820

申请日：2010-09-08

Applicant: Shubhayu Basu ,  Randolf von Oepen ,  Eugene Michal ,  Florian Ludwig

Inventor： Shubhayu Basu ,  Randolf von Oepen ,  Eugene Michal ,  Florian Ludwig

IPC: A61M25/00

CPC classification number: A61M25/1011 ,  A61B17/12045 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00495 ,  A61M25/003 ,  A61M2025/0092 ,  A61M2025/1052

Abstract: A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.

Abstract translation: 通过将输送装置通过血管壁引导到心肌内的治疗部位，在心肌内形成增强区域。 然后当从处理部位取出输送装置以形成加强区域时，将生物材料输送到处理部位。 加强区域的形成可以进一步包括将输送装置通过血管壁引入心肌内的区域，使得输送装置位于基本上平行于心肌壁的心肌内。 生物材料可以通过输送装置输送到在该区域内形成的空间中。 加强区域可以围绕心肌的梗塞组织区域形成以加强受损组织。

公开(公告)号：US20110077618A1

公开(公告)日：2011-03-31

申请号：US12963397

申请日：2010-12-08

Applicant: Shubhayu Basu ,  Greg W. Chan

Inventor： Shubhayu Basu ,  Greg W. Chan

IPC: A61M5/32 ,  A61M5/31

CPC classification number: A61M25/003 ,  A61M25/00 ,  A61M25/0032 ,  A61M25/0084 ,  A61M25/10

Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.

Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。

公开(公告)号：US20080125745A1

公开(公告)日：2008-05-29

申请号：US11978986

申请日：2007-10-29

Applicant: Shubhayu Basu ,  Greg W. Chan

Inventor： Shubhayu Basu ,  Greg W. Chan

IPC: A61M25/00

CPC classification number: A61M25/003 ,  A61M25/00 ,  A61M25/0032 ,  A61M25/0084 ,  A61M25/10

Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.

Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。

公开(公告)号：US20240198037A1

公开(公告)日：2024-06-20

申请号：US18595054

申请日：2024-03-04

Applicant: Shubhayu Basu ,  Dustin R. Tobey ,  Pieter E. Van Niekerk ,  Cesar Fuentes-Ortega

Inventor： Shubhayu Basu ,  Dustin R. Tobey ,  Pieter E. Van Niekerk ,  Cesar Fuentes-Ortega

IPC: A61M25/00 ,  A61B17/00 ,  A61B18/00 ,  A61B18/14 ,  A61B90/00

CPC classification number: A61M25/0009 ,  A61B90/06 ,  A61B2017/00526 ,  A61B2018/00083 ,  A61B2018/00577 ,  A61B2018/00619 ,  A61B2018/00821 ,  A61B18/1492 ,  A61B2090/064 ,  A61B2562/0261

Abstract: A method is used to manufacture a surgical instrument. The surgical instrument includes a catheter and an end effector extending distally from the catheter. The method includes forming at least one electrode, sensor, or thermocouple onto the catheter or the end effector of the surgical instrument by etching or vapor depositing a three-dimensional structure onto a non-conductive material that is layered over a super elastic material.

公开(公告)号：US08784894B2

公开(公告)日：2014-07-22

申请号：US11485934

申请日：2006-07-12

Applicant: Shubhayu Basu ,  Eugene T. Michal

Inventor： Shubhayu Basu ,  Eugene T. Michal

IPC: A61K38/18 ,  A61K9/14

CPC classification number: A61K9/4833 ,  A61K9/145 ,  A61K9/5031 ,  A61K38/30

Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

公开(公告)号：US20120041257A1

公开(公告)日：2012-02-16

申请号：US12855469

申请日：2010-08-12

Applicant: John J. Stankus ,  Barbara E. Stamberg ,  Pamela A. Kramer-Brown ,  Jesus Magana ,  Shubhayu Basu ,  Yuet Mei Khong ,  Florian N. Ludwig

Inventor： John J. Stankus ,  Barbara E. Stamberg ,  Pamela A. Kramer-Brown ,  Jesus Magana ,  Shubhayu Basu ,  Yuet Mei Khong ,  Florian N. Ludwig

IPC: A61F2/00

CPC classification number: A61F2/2487 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12122 ,  A61B17/12181 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/0647 ,  A61L2430/20

Abstract: Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.

Abstract translation: 公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。 支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。 锚固体可以将材料层固定到心肌。 可以将多层生物相容性材料分别放置在心室中以形成支架。 在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。

公开(公告)号：US20100004627A1

公开(公告)日：2010-01-07

申请号：US12167791

申请日：2008-07-03

Applicant: Florian N. Ludwig ,  Shubhayu Basu

Inventor： Florian N. Ludwig ,  Shubhayu Basu

IPC: A61M25/00 ,  A61M5/32

CPC classification number: A61M25/0068 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0081 ,  A61M2025/009

Abstract: A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.

Abstract translation: 一种针导管，其构造成用于将药剂注射到患者体腔的壁中，其将针从导管的远侧末端引导到相对于轴的轴线成一定角度的体腔的壁中。 所产生的角度注射通道改善了药剂在体腔壁中的保留性，同时保持导管的远端部分基本上垂直于体腔壁，以最佳地推动注射部位处的组织。

公开(公告)号：US20090035381A1

公开(公告)日：2009-02-05

申请号：US11832257

申请日：2007-08-01

Applicant: John J. Stankus ,  Shubhayu Basu

Inventor： John J. Stankus ,  Shubhayu Basu

IPC: A61K47/30 ,  A61K38/18 ,  A61K9/14 ,  B29B13/08 ,  B29B9/00

CPC classification number: A61K9/0024 ,  A61K9/5031 ,  A61K9/5073 ,  A61K9/5089 ,  B05B5/001 ,  B05B5/025

Abstract: Electrospray systems and modified electrospray systems for the fabrication of core-shell particles for controlled-release and/or sustained-release treatment and delivery are herein disclosed. The electrospray system may include between one and a plurality of co-axially situated tubes. Each tube may be electrically connected to a power supply wherein a voltage may be applied thereto. Core-shell particles may be collected on a collection target, which may be a wet or dry collector, and electrically connected to the power supply. Core-shell particles and methods of manufacture are also disclosed. The precursors of the core-shell particles may be polymer- or biomacromolecule-based solutions and may include at least one treatment agent incorporated therein. The number of “core” particle(s) within the “shell” may vary and may provide different treatment agent release profiles depending on the material and/or chemical characteristics of the polymer and/or biomacromolecule used. Methods of treating a condition are also disclosed. A treatment may include delivery of a plurality of core-shell particles which include a treatment agent to a treatment site. Delivery may be performed by a surgical procedure or by a non-invasive procedure such as catheter delivery.

Abstract translation: 本文公开了用于制备用于控制释放和/或持续释放处理和递送的核 - 壳颗粒的电喷雾系统和改进的电喷雾系统。 电喷雾系统可以包括在一个和多个同轴位于的管之间。 每个管可以电连接到电源，其中可以施加电压。 核 - 壳颗粒可以收集在收集目标上，其可以是湿的或干的收集器，并且电连接到电源。 还公开了核 - 壳颗粒和制造方法。 核 - 壳颗粒的前体可以是基于聚合物或生物大分子的溶液，并且可以包括并入其中的至少一种处理剂。 “壳”内的“芯”颗粒的数量可以变化，并且可以根据所使用的聚合物和/或生物大分子的材料和/或化学特性提供不同的处理剂释放曲线。 还公开了治疗病症的方法。 治疗可以包括将包括治疗剂的多个核 - 壳颗粒递送到治疗部位。 可以通过外科手术或非侵入性手术（例如导管递送）进行输送。

公开(公告)号：US20080014276A1

公开(公告)日：2008-01-17

申请号：US11485934

申请日：2006-07-12

Applicant: Shubhayu Basu ,  Eugene T. Michal

Inventor： Shubhayu Basu ,  Eugene T. Michal

IPC: A61K38/18 ,  A61K9/14

CPC classification number: A61K9/4833 ,  A61K9/145 ,  A61K9/5031 ,  A61K38/30

Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.

Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将其与生物可蚀塑料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。