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    ELECTROSPRAYING METHOD FOR FABRICATION OF PARTICLES AND COATINGS AND TREATMENT METHODS THEREOF
    5.
    发明申请
    ELECTROSPRAYING METHOD FOR FABRICATION OF PARTICLES AND COATINGS AND TREATMENT METHODS THEREOF 审中-公开
    用于制备颗粒和涂层的电喷涂方法及其处理方法

    公开(公告)号：US20090035381A1

    公开(公告)日：2009-02-05

    申请号：US11832257

    申请日：2007-08-01

    Applicant: John J. Stankus ,  Shubhayu Basu

    Inventor： John J. Stankus ,  Shubhayu Basu

    IPC: A61K47/30 ,  A61K38/18 ,  A61K9/14 ,  B29B13/08 ,  B29B9/00

    CPC classification number: A61K9/0024 ,  A61K9/5031 ,  A61K9/5073 ,  A61K9/5089 ,  B05B5/001 ,  B05B5/025

    Abstract: Electrospray systems and modified electrospray systems for the fabrication of core-shell particles for controlled-release and/or sustained-release treatment and delivery are herein disclosed. The electrospray system may include between one and a plurality of co-axially situated tubes. Each tube may be electrically connected to a power supply wherein a voltage may be applied thereto. Core-shell particles may be collected on a collection target, which may be a wet or dry collector, and electrically connected to the power supply. Core-shell particles and methods of manufacture are also disclosed. The precursors of the core-shell particles may be polymer- or biomacromolecule-based solutions and may include at least one treatment agent incorporated therein. The number of “core” particle(s) within the “shell” may vary and may provide different treatment agent release profiles depending on the material and/or chemical characteristics of the polymer and/or biomacromolecule used. Methods of treating a condition are also disclosed. A treatment may include delivery of a plurality of core-shell particles which include a treatment agent to a treatment site. Delivery may be performed by a surgical procedure or by a non-invasive procedure such as catheter delivery.

    Abstract translation: 本文公开了用于制备用于控制释放和/或持续释放处理和递送的核 - 壳颗粒的电喷雾系统和改进的电喷雾系统。 电喷雾系统可以包括在一个和多个同轴位于的管之间。 每个管可以电连接到电源，其中可以施加电压。 核 - 壳颗粒可以收集在收集目标上，其可以是湿的或干的收集器，并且电连接到电源。 还公开了核 - 壳颗粒和制造方法。 核 - 壳颗粒的前体可以是基于聚合物或生物大分子的溶液，并且可以包括并入其中的至少一种处理剂。 “壳”内的“芯”颗粒的数量可以变化，并且可以根据所使用的聚合物和/或生物大分子的材料和/或化学特性提供不同的处理剂释放曲线。 还公开了治疗病症的方法。 治疗可以包括将包括治疗剂的多个核 - 壳颗粒递送到治疗部位。 可以通过外科手术或非侵入性手术（例如导管递送）进行输送。

    Modified Two-Component Gelation Systems, Methods of Use and Methods of Manufacture
    7.
    发明申请
    Modified Two-Component Gelation Systems, Methods of Use and Methods of Manufacture 有权
    改进的双组分凝胶化系统，使用方法和制造方法

    公开(公告)号：US20100196313A1

    公开(公告)日：2010-08-05

    申请号：US12756092

    申请日：2010-04-07

    Applicant: Eugene Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

    Inventor： Eugene Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

    IPC: A61K38/20 ,  A61K35/12 ,  A61K38/16 ,  A61P9/10 ,  A61K38/19

    CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/12 ,  A61K38/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/50 ,  A61K2300/00

    Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.

    Abstract translation: 本文公开了组合物，制造方法和心肌梗死后治疗方法。 在一些实施方案中，组合物包含至少两种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物和具有至少一个细胞粘附位点的物质，其在约6.5的pH下在第一缓冲液中合并。 第二组分可以包括pH在约7.5和9.0之间的第二缓冲液。 第二官能化聚合物可以包括在第一或第二组分中。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，本发明的组合物可以通过双孔注射装置递送至治疗区域，例如心肌梗死后区域。

    Modified two-component gelation systems, methods of use and methods of manufacture
    9.
    发明授权
    Modified two-component gelation systems, methods of use and methods of manufacture 有权
    改进的双组分凝胶化系统，使用方法和制造方法

    公开(公告)号：US08486387B2

    公开(公告)日：2013-07-16

    申请号：US12756119

    申请日：2010-04-07

    Applicant: Eugene Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

    Inventor： Eugene Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

    IPC: A61K31/00 ,  A61K9/00 ,  A61M5/19 ,  A61K38/18 ,  A61M5/00 ,  A61M31/00 ,  A61P9/00

    CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/12 ,  A61K38/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/50 ,  A61K2300/00

    Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.

    Abstract translation: 本文公开了组合物，制造方法和心肌梗死后治疗方法。 在一些实施方案中，组合物包含至少两种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物和具有至少一个细胞粘附位点的物质，其在约6.5的pH下在第一缓冲液中合并。 第二组分可以包括pH在约7.5和9.0之间的第二缓冲液。 第二官能化聚合物可以包括在第一或第二组分中。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，本发明的组合物可以通过双孔注射装置递送至治疗区域，例如心肌梗死后区域。

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