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公开(公告)号：US08888675B2
公开(公告)日：2014-11-18
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00 , A61N1/362 , A61B17/12 , A61B17/064 , A61F2/24 , A61B17/068
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译： 公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。 支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。 锚固体可以将材料层固定到心肌。 可以将多层生物相容性材料分别放置在心室中以形成支架。 在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。
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公开(公告)号：US20120041257A1
公开(公告)日：2012-02-16
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译： 公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。 支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。 锚固体可以将材料层固定到心肌。 可以将多层生物相容性材料分别放置在心室中以形成支架。 在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。
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公开(公告)号：US09265866B2
公开(公告)日：2016-02-23
申请号：US11888500
申请日：2007-07-31
CPC分类号： A61L31/18 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2210/0004 , A61F2250/0067 , A61F2250/0096 , A61F2250/0097 , A61L31/08 , A61L31/128 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/606 , C08L67/04
摘要： Various embodiments of stents with a polymeric body with radiopaque metallic particles incorporated in the stent body.
摘要翻译： 具有聚合体的支架的各种实施例，其具有结合在支架主体中的不透射线金属颗粒。
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4.发明申请METHODS AND SYSTEMS FOR LASER CUTTING AND PROCESSING TUBING TO MAKE MEDICAL DEVICES 有权用于激光切割和加工管道以制造医疗装置的方法和系统公开(公告)号：US20100193485A1
公开(公告)日：2010-08-05
申请号：US12757842
申请日：2010-04-09
申请人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMore , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf Von Oepen , William E. Webler, JR. , Travis R. Yribarren
发明人： Boris Anukhin , Larry Baughman , Pamela A. Kramer-Brown , Neil Burkhart , Li Chen , Duane M. DeMore , Keif Fitzgerald , Gregory W. Johnson , Z. C. Lin , David Mackiewicz , Karim S. Osman , Randolf Von Oepen , William E. Webler, JR. , Travis R. Yribarren
IPC分类号： B23K26/18
CPC分类号： B23K26/4005 , A61F2/07 , A61F2/91 , B23K26/16 , B23K26/38 , B23K26/40 , B23K26/402 , B23K2101/04 , B23K2101/06 , B23K2103/50
摘要： Methods for making devices include providing a tubular member to be formed into a device, placing a removable sacrificial block material in the lumen of the tubular member and laser cutting the tubular member. A doping material can be added to the melted portion of the tubular member to promote the formation of brittle slag. A fixture can be used to hold a cut workpiece in order to ream sacrificial material from the surface of the workpiece. Pressurized gas can be supplied to the inner lumen of the tubular member to cause slag to form on the outside surface, rather than the inner surface, of the tubular member. A tubular member made from nickel-titanium alloy can be tightly adhered to a sacrificial sleeve utilizing the phase changes associated with nickel-titanium. A rotating mandrel can be placed within the lumen of the tubular member during laser cutting. A mandrel which includes an enlarged diameter section causes the workpiece to expand slightly within its elastic deformation range to dislodge islands from the workpiece. Such a mandrel could be formed from a tubular member which has a central lumen that can be used to deliver a pressurized medium to “blast” islands from the workpiece.
摘要翻译： 制造装置的方法包括提供要形成装置的管状构件，将可移除的牺牲块材料放置在管状构件的内腔中并激光切割管状构件。 可以将掺杂材料添加到管状构件的熔融部分中以促进脆性炉渣的形成。 夹具可用于夹持切割的工件，以便从工件的表面获得牺牲材料。 加压气体可以供应到管状构件的内腔，以在管状构件的外表面而不是内表面上形成炉渣。 利用与镍 - 钛相关联的相变，由镍 - 钛合金制成的管状部件可以紧密地粘附到牺牲套管上。 在激光切割期间，旋转心轴可以放置在管状构件的内腔内。 包括扩大直径部分的心轴使得工件在其弹性变形范围内稍微膨胀以从工件移除岛。 这种心轴可以由管状构件形成，该管状构件具有可用于将加压介质输送到工件的“鼓风”岛的中心腔。
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公开(公告)号：US08496615B2
公开(公告)日：2013-07-30
申请号：US13446761
申请日：2012-04-13
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
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公开(公告)号：US08252361B2
公开(公告)日：2012-08-28
申请号：US11946768
申请日：2007-11-28
IPC分类号： A61L33/00
CPC分类号： A61L31/16 , A61L29/049 , A61L29/085 , A61L29/148 , A61L31/041 , A61L31/10 , A61L31/148 , A61L2300/602 , A61L2300/62 , C08L77/12 , C08L67/04
摘要： Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.
摘要翻译： 公开了适用于本地和区域处理的适用于可释放释放输送介质的可植入医疗装置。
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7.发明申请RADIOPAQUE INTRALUMINAL STENTS COMPRISING COBALT-BASED ALLOYS CONTAINING ONE OR MORE PLATINUM GROUP METALS, REFRACTORY METALS, OR COMBINATIONS THEREOF 审中-公开包含含有一种或多种铂族金属，碱金属或其组合的基于钴的合金的放射性体系公开(公告)号：US20120123525A1
公开(公告)日：2012-05-17
申请号：US13298070
申请日：2011-11-16
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61L31/18
摘要： Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Here, the term “refractory metals” include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, as well as the precious metals silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute for nickel, such that the alloy is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.
摘要翻译： 实施例涉及由包含钴，铬和一种或多种铂族金属，难熔金属或其组合的钴基合金形成的不透射线的可植入结构（例如，支架）。 铂族金属包括铂，钯，钌，铑，锇和铱。 这里，术语“难熔金属”包括锆，铌，铑，钼，铪，钽，钨，铼以及贵金属银和金。 在一个实施方案中，一种或多种包括的铂族或难熔金属代替镍，使得该合金基本上不含镍。 与包括更大量的镍的类似合金相比，支架表现出改善的射线不透性。
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公开(公告)号：US20080300573A1
公开(公告)日：2008-12-04
申请号：US11756376
申请日：2007-05-31
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
摘要翻译： 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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公开(公告)号：US09144509B2
公开(公告)日：2015-09-29
申请号：US12902405
申请日：2010-10-12
申请人： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolpf von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren , William E. Webler, Jr.
发明人： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolpf von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren , William E. Webler, Jr.
摘要： Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.
摘要翻译： 公开了将药物或其它治疗剂局部递送到哺乳动物脉管系统的装置。 这些装置具有几种相关的结构，并被设计成递送药物以促进与流过装置的血液的快速混合。
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公开(公告)号：US09108028B2
公开(公告)日：2015-08-18
申请号：US13446768
申请日：2012-04-13
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
摘要翻译： 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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